(Poly)phenols are plant-derived food bioactives abundantly present in human diet. They exert positive effects on various aspects of human health, and in particular in reducing the risk of chronic non-communicable diseases. Dietary (poly)phenols have been reported to improve vascular function, blood lipids, insulin sensitivity, and to decrease systemic inflammation. Evidence also suggests that (poly)phenols may exert protective effects on DNA, by reducing the extent of its damage. In recent years, advanced analytical methods, including transcriptomics, metabolomics, proteomics, and metagenomics, have been employed to unravel the complex impact of (poly)phenols in health and disease. Advances in bioinformatics enable an integrated multi-omics approach to data analysis, opening avenues for discovering new, previously unknown molecular mechanisms of action. Innovative solutions and automation of the Comet assay offer new opportunities for more in-depth analysis of the impact of (poly)phenols on DNA damage and its inclusion in integrative bioinformatic models. Such an approach has the potential to uncover new multi-level interactions and to reveal previously unknown factors underlying inter-individual variabilities in health-promoting effects of (poly)phenols. This review provides an insight into the application of the Comet assay in human intervention studies using (poly)phenol-rich dietary sources. Recent advancements in the Comet assay technology, and the prospects for more extensive use of this method in future human intervention studies with (poly)phenols could contribute to the development of personalized dietary recommendations for these plant-derived food bioactives.

This study examines gender differences in inflation expectations, attitudes and responses using the UK Inflation Attitudes Survey. It finds minimal gender disparity in inflation perceptions and expectations but highlights greater uncertainty and inflation aversion among women. During inflationary periods, women are more likely to increase savings, whereas men typically push for higher wages. Gender gaps in financial knowledge and trust in the Bank of England (BoE) suggest tailored communication strategies may enhance engagement. While BoE policies effectively anchor expectations, improved outreach and diverse messaging could address women’s lower satisfaction and financial understanding. The findings underscore the role of inclusivity in effective monetary communication.

When and why did House parties identify exclusive committees? The nexus of parties and standing committees defines the distribution of power in the U.S. House of Representatives, shapes legislators’ careers, and affects Congress's ability to address the nation's problems. Yet, political science provides inadequate and often misleading characterizations of the parties and the most important standing committees. We provide missing detail and offer a historical perspective on party efforts to arrange standing committees in the period since the revolt against Speaker Joseph Cannon in 1909–1910. Our narrative offers a foundation for explaining party efforts to regulate committee membership and meet legislators’ demands. For the first time, we define three periods in committee assignment limitations. In doing so, we place key events in historical context: We report that the modern exclusive committees (Appropriations, Rules, and Ways and Means) did not become defined until the 1950s; the identification by the two parties of a larger set of exclusive committees for which a one-assignment limitation applied began decades earlier; the Legislative Reorganization Act of 1946 placed a one-assignment limitation in House rules that had been party practice for three decades by then. In recent decades, deep partisanship has been accompanied by a loosening, not tightening, of restrictions. In fact, there are no fully exclusive committees remaining in practice.

Using manually compiled cost of equity (COE) estimates disclosed in takeover regulatory filings, we provide novel evidence on how investment bankers estimate discount rates. COE estimates are related to several risk proxies, such as beta and size. Other firm characteristics are unrelated to COE estimates or provide relations contradicting academic evidence. We also explore the role of incentives. For example, banks use significantly higher COEs in management buyouts, which potentially underestimates target value, making the bid more attractive for target shareholder approval.

In this paper, we consider estimating spot/instantaneous volatility matrices of high-frequency data collected for a large number of assets. We first combine classic nonparametric kernel-based smoothing with a generalized shrinkage technique in the matrix estimation for noise-free data under a uniform sparsity assumption, a natural extension of the approximate sparsity commonly used in the literature. The uniform consistency property is derived for the proposed spot volatility matrix estimator with convergence rates comparable to the optimal minimax one. For high-frequency data contaminated by microstructure noise, we introduce a localized pre-averaging estimation method that reduces the effective magnitude of the noise. We then use the estimation tool developed in the noise-free scenario and derive the uniform convergence rates for the developed spot volatility matrix estimator. We further combine kernel smoothing with the shrinkage technique to estimate the time-varying volatility matrix of the high-dimensional noise vector. In addition, we consider large spot volatility matrix estimation in time-varying factor models with observable risk factors and derive the uniform convergence property. We provide numerical studies including simulation and empirical application to examine the performance of the proposed estimation methods in finite samples.

This paper investigates a rather unexpected connection between the alchemy of vermilion, mercury sulphide (HgS), and the primary red highlighted in a colour theory that emerged in the late fifteenth century: trichromacy of colour mixtures. Some early supporters of trichromacy indeed identified the hue of vermilion as the ideal simple red they discussed in their books. The colours observed during the manufacturing of this pigment led to the alchemical colour sequence described in texts and images about the sulphur–mercury theory, and they are in some recipes the same primary colours of trichromatists. This paper also shows that the era of vermilion lasted until the late eighteenth century, when vermilion was finally rejected by other trichromatists.

Let (W, S) be a Coxeter system of rank n, and let $p_{(W, S)}(t)$ be its growth function. It is known that $p_{(W, S)}(q^{-1}) \lt \infty$ holds for all $n \leq q \in \mathbb{N}$. In this paper, we will show that this still holds for $q = n-1$, if (W, S) is 2-spherical. Moreover, we will prove that $p_{(W, S)}(q^{-1}) = \infty$ holds for $q = n-2$, if the Coxeter diagram of (W, S) is the complete graph. These two results provide a complete characterization of the finiteness of the growth function in the case of 2-spherical Coxeter systems with a complete Coxeter diagram.

Since around 2005, an increasing number of songs have emerged in the Republic of Cyprus that use elements from the Greek Cypriot cultural heritage, like lyrics in Cypriot Greek, folk music features and other references to ‘tradition’. These songs belong to contemporary genres, including rock, metal, fusion and hip hop, genres that already existed in the country but became ‘localised’ in a different manner, owing to the socio-political context. This article presents the first attempt to situate the popular musicscape of the Republic of Cyprus within debates pertaining to global musical flows, describing this context and arguing that the turn to elements from the Greek Cypriot cultural heritage is a recent phenomenon. We argue that this process signifies a new era of music-making in the Republic of Cyprus that can be theorised as ‘cosmopolitan localism’.

Data on the behavioral development of preterm infants are inconclusive. The aim of this study was to explore behavioral development during preschool years, considering prematurity, measurement time, gender, and informant. This is a prospective longitudinal analytical observational study, with a sample of 98 parents and 98 teachers of children aged 4, 5, and 6 years with and without a history of prematurity, who were evaluated by the Child Behavior Checklist and Teacher’s Report Form. Parents and teachers of the preschoolers report average scores on all behavioral scales. We observed variability according to degree of prematurity, age, and informant. Teachers detected more attention difficulties in the very preterm group (VPTG) than in the born-at-term group at 4 years. Parents and teachers coincided in detecting greater withdrawal in the moderate and late preterm group (MTPG) compared to the born-at-term group and an increase in difficulties with increasing age. The General Linear Model revealed that moderate prematurity, the age of 6 years, and parental report have a greater risk of behavioral difficulties. The need for follow-up also in moderate preterm infants is emphasized, especially at 6 years of age and with multi-informants.

This study investigated associations between childhood neighborhood deprivation and adolescent mental health difficulties, and potential protective factors. Data were utilized from the Millennium Cohort Study (MCS) (born in 2000–2002; N = 5,422; 52% female) and the Environmental Risk (E-Risk) Longitudinal Twin Study (born in 1994–1995; N = 1,920; 53% female). Childhood neighborhood deprivation was measured using the Index of Multiple Deprivation between age 9 months and 14 years (MCS) and at age 12 (E-Risk). Adolescent mental health was assessed using the Strengths and Difficulties Questionnaire at age 17 (MCS) and the Diagnostic Interview Schedule conducted at age 18 with symptoms loading onto general psychopathology, internalizing and externalizing factors (E-Risk). Cross-classified models showed high levels of neighborhood deprivation in childhood were associated with more total problems (estimate = 0.46, 95% CI = 0.04–0.88) and internalizing difficulties (estimate = 0.32, 95% CI = 0.06–0.59) in adolescence within MCS. Being male, having higher self-esteem, greater social support, and a more positive parent-child relationship were associated with fewer total problems (estimates = −0.09–−1.87) and internalizing difficulties (estimates = −0.03–−1.88) at age 17 in the full sample regardless of neighborhood deprivation exposure. However, interactions revealed that higher self-esteem was especially beneficial for children exposed to high neighborhood deprivation (estimate = −0.35, 95% CI = −0.43–−0.27). No significant associations between childhood neighborhood deprivation and adolescent mental health symptoms were found in E-Risk. Interventions focused on improving self-esteem, social support, and parenting may help promote better adolescent mental health in the general population. Those living in the most deprived areas may benefit most from increased self-esteem.

This article offers a hermeneutical account of ambiguity using Luke and Acts as an extended case study. After discussing the difficulties in identifying purposeful ambiguity in biblical texts, verbal ambiguity is distinguished from ambiguity beyond the sentence level, such as ambiguities of plot or character. Instead of approaching ambiguity primarily as a failure of language or a problem to be solved, this article offers a framework for thinking about ambiguity as an invitation to read a text from multiple angles. The discussion is illustrated throughout with a series of examples taken from Luke and Acts. I close with reflections on how this approach to ambiguity is helpful when reading scripture against different cultural contexts and in the study of New Testament Christology.

Spectra have been obtained with multi-fibre instrument 2dF on the Anglo-Australian Telescope of 89 candidate main sequence stars in the globular cluster M55 (NGC 6809). Radial velocities and Gaia proper motions confirm 72 candidates as cluster members. Among these stars one stands out as having a substantially stronger G-band (CH) than the rest of the member sample. The star is a dwarf carbon star that most likely acquired the high carbon abundance ([C/Fe] ≈ 1.2 ± 0.2) via mass transfer from a ∼1–3 M⊙ binary companion (now a white dwarf) during its AGB phase of evolution. Interestingly, M55 also contains a CH-star that lies on the cluster red giant branch – the low central concentration/low density of this cluster presumably allows the survival of binaries that would otherwise be disrupted in denser systems. The existence of carbon stars in six other globular clusters is consistent with this hypothesis, while the origin of the carbon-enhanced star in M15 (NGC 7078) is attributed to a merger process similar to that proposed for the origin of the carbon-rich R stars.