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The environmental conditions for the origin of life are still not well-constrained, but membrane-bound structures must have been key to the origin of life. Membranes composed of fatty acids are promising candidates due to their simplicity and plausible prevalence in prebiotic environments. To assess the stability of membranes composed of fatty acids with tail lengths ranging from 12 to 16 carbons at different temperatures and sodium chloride concentrations that may have existed on the early Earth, we conducted all-atom molecular dynamics (MD) simulations. In the absence of salt (freshwater), none of the fatty acids exhibited bilayer formation, whether below or above their chain melting temperature. However, elevating the salt concentration from 0.15 M (saline solution), 0.5 M (seawater), 1 M (seawater tide pools), 3 M (salty tide pools) and 5 M (Dead Sea) resulted in the formation of stable bilayers. The 16-carbon fatty acid required lower salt concentration, while shorter, 12-carbon chain necessitated higher salt levels. Increasing the salt concentration led to three main effects: (1) increased bilayer thickness, (2) reduced area per fatty acid and (3) elevated deuterium order parameter of the chains, resulting in more robust membranes. Our simulations indicated that the salt cations aggregated on the bilayer surfaces, effectively mitigating repulsive interactions among hydrophilic fatty acid head groups. These findings suggest that fatty acid bilayers are more likely present in ancient waters connected to saltwater reservoirs, or seawater tide pools with elevated salt concentrations.
James Dolbow, University Hospital Cleveland Medical Center,Joshua Edmondson, University Hospital Cleveland Medical Center,Neel Fotedar, University Hospital Cleveland Medical Center
I know, I know! This one is super tough, solely based on the need to look up Latin and Greek origins to make sense of it. The foramen ovale gets its name from the early Latin word ovum meaning egg, which would later become ovalis and then the word “oval,” which is an egg-shaped circle. It is positioned within the sphenoid bone which means “wedge-shaped,” sphenoeides in Greek. Only V3, the third branch of the trigeminal nerve, passes through it.
Chapter 4 focuses on the early seventeenth century, when religious policy in the kingdom came to be in the hands of a determined new Audiencia president, an ambitious archbishop, and a radical group of Jesuits. With the support of a broad coalition of the kingdom’s leading settlers, these reformers took Christianisation in a new direction. The reformers focused on the promotion of the regular and frequent participation in a range of quotidian Catholic practices and institutions that their sixteenth-century predecessors had generally discouraged or withheld from Indigenous people, particularly private devotions, popular celebrations, confraternities, and public ceremony. This began in a handful of parishes entrusted to these Jesuit reformers, who had a very particular understanding of the role of ‘external’ manifestations of piety, and who used these sites as testing grounds for new approaches to Christianisation. These ultimately had the effect of affording Indigenous people space and opportunities to engage with Christianity in new – if, for the reformers, not always desirable – ways, laying the foundations for the reformation of the kingdom.
James Dolbow, University Hospital Cleveland Medical Center,Joshua Edmondson, University Hospital Cleveland Medical Center,Neel Fotedar, University Hospital Cleveland Medical Center
The superior cervical ganglion is formed by the fusion of paravertebral ganglia in the cervical region C1–C4. It is located at the level of C2 and C3 vertebrae and just behind the internal carotid artery, just after it branches from the common carotid artery.
This chapter reconstructs the ethical ambiguities and popular anxieties that emerged during a spectacular period of coffee smuggling in the 1970s, centered in Chepkube village near the border of Kenya and Uganda. The criminalized trade provided residents with newfound wealth and consumptive possibility; magendo, as it was known, also was a stark challenge to the Ugandan state’s ability to monopolize the valuation of its most important export. However, participants’ unease did not reflect the illegality of magendo. Rather, the excessive and rapid riches acquired through coffee smuggling challenged prevailing ideas of propriety, respectability, and morality. In other words, existing ideas about how proper value should be morally produced—through laborious effort and familial networks—were undermined by the sudden revaluation of coffee. Smuggling is a form of arbitrage, a style of economic action premised on the capitalization on disjunctures of jurisdiction, of measurement, and of appearance. Magendo participants actively worked to produce such differences in order to acquire wealth; yet arbitrage generated an ambiguous mix of desire and disdain. Based on oral histories and fieldwork on both sides of the border, this chapter reveals how the careful orchestration of social relations and material goods is at the heart of valuation, and it emphasizes how popular valuation practices change and conflict with state projects of governing value and defining citizenship.
This chapter is about low-tier prostitution. In China, selling sex in the lowest tier of prostitution is both difficult and dangerous. Women who do so solicit either on the streets or in small brothels located in apartments or in businesses that masquerade as hair salons or massage parlors. In all of these spaces, work conditions are grueling and take their toll on sex workers’ health. The threat of violence and even death at the hands of clients, madams, and pimps looms large. The beliefs and attitudes of women who sell sex on the streets and in brothels reflect these challenging experiences. Women in this tier are critical of prostitution and of themselves for engaging in it, and oppose proposals to legalize it. They also view the state with suspicion and do not feel comfortable seeking assistance from the police when doing so would reveal that they engage in prostitution. Within Chinese society, the lives of low-tier sex workers elicit both disgust and pity.
This chapter analyzes the right in Venezuela under Chavismo. It argues that the main divide of Venezuelan politics is now between democracy and autocracy rather than the ideological left and right. As authoritarianism and repression have increased and Venezuela’s socioeconomic decline has worsened, right-wing movements and factions have prioritized competitiveness through a centrist approach over an emphasis on ideological purity.
James Dolbow, University Hospital Cleveland Medical Center,Joshua Edmondson, University Hospital Cleveland Medical Center,Neel Fotedar, University Hospital Cleveland Medical Center
The spinothalamic tract is an ascending pathway that carries pain and temperature sensation, that is, how you would know you burnt your hand. The first-order sensory neuron located in the dorsal root ganglion receives sensory information mainly via Aα and C fibers. The axons from the first-order neuron enter the spinal cord via the dorsal root. As opposed to the dorsal column pathway, these axons synapse immediately in laminae I and V of the dorsal root gray matter (substantia gelationsa). The axons from the second-order neurons then immediately cross to the contralateral side of the spinal cord through the central gray matter and ascend via a lateral tract in the spinal cord to synapse in the contralateral thalamus. Some of the axons first ascend or descend via Lissauer’s tract before crossing to the contralateral side.
Chapter 2 discusses prostitution in Chinese history and provides the context surrounding prostitution in contemporary China. Sex work has presented the state with regulatory challenges throughout most of Chinese history. In Imperial China (361 BC–1912 CE), prostitution policy varied based on the status of the men and women involved. In Republican China (1912–1949), the regulation of sex work was formulated primarily at the local level. Some local governments sought to abolish it, but they were more likely to license and tax it, or to establish state-run brothels. When the Chinese Communist Party (CCP) came to power in 1949, it moved swiftly to prohibit prostitution nationwide, and in the first few decades of the People’s Republic of China (PRC), prostitution was less prevalent and more hidden. Yet the scarcity of prostitution during the Mao era is best viewed as a brief historical anomaly. Sex work reemerged in the early 1980s, in the wake of Deng Xiaoping’s policy of reform and opening, and it has been integral to many of the country’s major political, economic, and social developments since 1979.
This chapter is about middle-tier prostitution. The life of a hostess is exhausting. In addition to selling sex, women in this tier of the sex industry spend hours every evening engaging in their other professional responsibilities, which include drinking, dancing, and singing with clients. They face intense competition from their peers. Their work environment exposes them to health risks not only from HIV/AIDS and other sexually transmitted diseases, but also from the alcohol and tobacco they consume as part of their work. Although these conditions are taxing, they also provide middle-tier sex workers with more agency than their colleagues who work on the streets or in brothels, and lead to these women having more positive perspectives on prostitution than do their lower-tier colleagues. Hostesses tend to be assertive and reject any portrayal of their engagement in the sex industry as a story of victimhood. They also exhibit more trust in government institutions, an attitude that on rare occasions can even lead them to make public demands of the state. This work environment, autonomy and initiative contribute to public perceptions that tend to criticize hostesses as lazy and dishonorable.
Edited by
Daniel Benoliel, University of Haifa, Israel,Peter K. Yu, Texas A & M University School of Law,Francis Gurry, World Intellectual Property Organization,Keun Lee, Seoul National University
Euler angles and rotation matrices; construction and properties of the rotation matrices; transformation of irreducible tensor operators under rotations; fine-structure of the hydrogen atom; hydrogen atom in a magnetic field: Zeeman and Paschen-Back effects; hyperfine structure of the hydrogen atom; tensor operators; time reversal and irreducible tensor operators.