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Feasibility of Measuring Physical Function by Wearable Devices During Deprescribing of Anticholinergic and Sedative Medicatiossns

Published online by Cambridge University Press:  27 February 2025

Benoit Cossette ,
Patrick Boissy ,
Marie-Hélène Milot ,
Sarah N Hilmer ,
Lisa Kouladjian O’donnell Open the ORCID record for Lisa Kouladjian O’donnell [Opens in a new window] ,
Danijela Gnjidic ,
Caroline Sirois ,
Dee Mangin ,
Geneviève Ricard  and
Jennifer E. Isenor
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Benoit Cossette*
Affiliation:
Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada Research Center on Aging, CIUSSS de l’Estrie-CHUS, Sherbrooke, QC, Canada
Patrick Boissy
Affiliation:
Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada Research Center on Aging, CIUSSS de l’Estrie-CHUS, Sherbrooke, QC, Canada
Marie-Hélène Milot
Affiliation:
Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada Research Center on Aging, CIUSSS de l’Estrie-CHUS, Sherbrooke, QC, Canada
Sarah N Hilmer
Affiliation:
Laboratory of Ageing and Pharmacology, Kolling Institute, Faculty of Medicine and Health, The University of Sydney and Northern Sydney Local Health District, Sydney, NSW, Australia
Lisa Kouladjian O’donnell
Affiliation:
Laboratory of Ageing and Pharmacology, Kolling Institute, Faculty of Medicine and Health, The University of Sydney and Northern Sydney Local Health District, Sydney, NSW, Australia
Danijela Gnjidic
Affiliation:
Faculty of Medicine and Health, School of Pharmacy, The University of Sydney, Sydney, NSW, Australia
Caroline Sirois
Affiliation:
Faculté de pharmacie, Université Laval, Québec, QC, Canada Centre d’excellence sur le vieillissement de Québec and VITAM, Centre de recherche en santé durable, Québec, QC, Canada Centre de recherche du CHU de Québec, Université Laval, Québec, QC, Canada
Dee Mangin
Affiliation:
Department of Family Medicine, McMaster University, Hamilton, ON, Canada Department of General Practice, University of Otago, Christchurch, New Zealand
Geneviève Ricard
Affiliation:
Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada
Jennifer E. Isenor
Affiliation:
College of Pharmacy, Faculty of Health, Dalhousie University, Halifax, Nova Scotia, Canada
Jacynthe Roy-Petit
Affiliation:
Pharmacy Department, CIUSSS de l’Estrie-CHUS, Sherbrooke, QC, Canada
Bessam Abdulrazak
Affiliation:
Faculty of Sciences, University of Sherbrooke, Sherbrooke, QC, Canada
Marilyn Tousignant
Affiliation:
Research Center on Aging, CIUSSS de l’Estrie-CHUS, Sherbrooke, QC, Canada
Karina Lebel
Affiliation:
Research Center on Aging, CIUSSS de l’Estrie-CHUS, Sherbrooke, QC, Canada Faculty of Engineering, University of Sherbrooke, Sherbrooke, QC, Canada
*
Corresponding author: La correspondance et les demandes de tirés-à-part doivent être adressées à : / Correspondence and requests for offprints should be sent to: Benoit Cossette, PhD, Research Center on Aging, CIUSSS de l’Estrie-CHUS, 1036, Belvedere South, Sherbrooke, Québec, Canada J1H 4C4 ([email protected]).
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Abstract

Cumulative exposure to anticholinergic and sedative medications has been associated with worsening physical function in older adults. We evaluated the feasibility of measuring physical function using wearable devices and explored the impact of reducing the anticholinergic and sedative medication burden in a pilot study of community-dwelling adults aged 60 years and older. Evaluations included the 10-meter walk test (10MWT), the Short Physical Performance Battery (SPPB), and the mini-BESTest. Two participants/month were recruited in one clinic in 2022. The five participants had a median age of 67, a median DBI of 1.7, and four were female. The feasibility analysis showed that the 10MWT and SPPB tests were completed on 12/12, and the mini-BESTest on 11/12. An exploratory analysis showed clinically meaningful improvements in gait speed (mean +0.18 m/s) and SPPB (mean +2.2 points). We showed the feasibility of measuring physical function by wearable devices during deprescribing of anticholinergic and sedative medications.

Résumé

Résumé

L’usage cumulatif de médicaments anticholinergiques et sédatifs a été associé à une détérioration de la fonction physique chez les aînés. Nous avons évalué la faisabilité de mesurer la fonction physique à l’aide de capteurs portés et exploré l’impact de la déprescription des médicaments anticholinergiques et sédatifs dans une étude pilote auprès d’adultes âgés de 60 ans et plus vivant dans la communauté. Les évaluations incluaient le test de marche de 10 mètres (TM10M), le Short Physical Performance Battery (SPPB) et le mini-BESTest. Deux participants par mois ont été recrutés dans une clinique en 2022. Les cinq participants avaient un âge médian de 67 ans, un DBI médian de 1,7 et quatre étaient des femmes. L’analyse de faisabilité a montré que les tests TM10M et SPPB ont été réalisés pour 12/12 visites de laboratoire, le mini-BESTest pour 11/12. Une analyse exploratoire a montré des améliorations cliniquement significatives pour la vitesse de marche (+0,18 m/s en moyenne) et le SPPB (+2,2 points en moyenne). Nous avons montré la faisabilité de mesurer la fonction physique par des capteurs portés lors de la déprescription de médicaments anticholinergiques et sédatifs.

Keywords

agingdeprescribinganticholinergicsedativeolder adultsphysical functionwearable devicesvieillissementdéprescriptionanticholinergiquessédatifsaînésfonction physiquecapteurs portés
Type
Article
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , First View , pp. 1 - 8
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Copyright
© Canadian Association on Gerontology 2025

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