First responders to disasters are at risk of developing post-traumatic stress disorder (PTSD). The trajectories of post-traumatic stress symptom severity differ among individuals, even if they are exposed to similar events. These trajectories have not yet been reported in non-Western first responders.

We aimed to explore post-traumatic stress symptom severity trajectories and their risk factors in first responders to the 2011 Great East Japan Earthquake (GEJE)— a historically large earthquake that resulted in a tsunami and a nuclear disaster.

56 388 Japan Ground Self-Defense Force (JGSDF) personnel dispatched to the GEJE were enrolled in this seven-year longitudinal cohort study. PTSD symptom severity was measured using the Impact of Event Scale-Revised (IES-R). Trajectories were identified using latent growth mixture models (LGMM). Nine potential risk factors for the symptom severity trajectories were analyzed using multinomial logistic regression.

Five symptom severity trajectories were identified: “resilient” (54.7%), “recovery” (24.5%), “incomplete recovery” (10.7%), “late-onset” (5.7%), and “chronic” (4.3%). The main risk factors for the four non-resilient trajectories were older age, personal disaster experiences, and working conditions. These working conditions included duties involving body recovery or radiation exposure risk, longer deployment length, later or no post-deployment leave, and longer post-deployment overtime.

The majority of first responders to GEJE were resilient and developed few or no PTSD symptoms. A substantial minority experienced late-onset and chronic symptom severity trajectories. The identified risk factors can inform policies for prevention, early detection, and intervention in individuals at risk of developing symptomatic trajectories.

No significant relationships.

Central glucocorticoid receptor (GR) has been found to play an important role in the interpretation of cognitive abnormalities of posttraumatic stress disorder (PTSD), particularly focused on the extinction failure of fear memory. Potential of using GR antagonist as a pharmacological agent to prevent PTSD-related fear memory disruption is worth investigating.

We aimed to examine whether GR antagonist Mifepristone (RU486) administered before single prolonged stress (SPS) can prevent rats from fear memory extinction impairment.

In the present study, SPS was employed in rats to induce a rodent model of PTSD. 60 minutes before SPS, RU486 (20 mg/kg) was administered by intraperitoneal injection. Seven days after SPS, rats received a protocol of behavioral testing to measure their abilities of specific fear memory (by a cue-dependent fear conditioning paradigm) and nonspecific spatial memory (by T-maze). Neurochemically, we measured plasma corticosterone with or without dexamethasone suppression, activation ratio of GR and levels of norepinephrine, dopamine, and serotonin in amygdala, paraventricular nucleus, dorsal and ventral hippocampus.

Our results found that RU486 exerted protective effects on SPS-induced fear extinction impairment. Corticosterone of SPS-RU486 rats was less suppressed by dexamethasone. GR became less activated in dorsal hippocampus of SPS-RU486 rats.

The findings supported the utility of GR antagonism in preventing the development of PTSD.

No significant relationships.

The development of emotional intelligence is an urgent issue of teaching people in our time. The use of a virtual reality (VR) systems for the development of emotional intelligence is a problem of modern pedagogy.

The research is aimed at studying interrelations of the level of development of emotional intelligence the manifestations of the ability to perceive and identify emotional expression demonstrated by a virtual avatar in VR CAVE system. The research is aimed at finding unusual ways to develop emotional intelligence.

The study involved 55 participants aged 18 to 25 years (average age-20.38 ± 0.28), 23 of whom were men and 22 were women. During the study we diagnosed the level of development of emotional intelligence (Sergienko, Vetrova, 2009) and spatial abilities (Rimfeld et al., 2017), type of attachment to the loved one (Sabelnikova, Kashirsky, 2015), and the negotiating style of personality (Soldatova, Gasimov, 2019). In the VR CAVE system, a situation was simulated in which the subject had to detect the avatar and determine the emotional-facial expression displayed by it.

It was shown that the level of respondent’s emotional intelligence development does not determine the success of identifying the avatar’s emotion in VR. The success of identifying emotions depends on the level spatial abilities development. Therefore, it is assumed that in the simulated situation, the avatar is perceived as a special spatial image, and not as a full-fledged partner for interpersonal communication.

Thus, the use of VR systems for training and development of emotional intelligence is not proven.

No significant relationships.

The evidence for the positive effects of mindfulness-based interventions on psychological well-being and physical health has been convincing in recent years. As a specific form of such an intervention, the Mindful Self-Compassion (MSC) training program was developed to promote self-compassion and mindfulness. An initial study on an adapted version of the MSC training program considered it to be beneficial in psychiatric inpatient rehabilitation.

The present study aims to further evaluate the link between MSC and psychological symptoms as well as quality of life.

A randomized controlled trial was conducted from September 2020 to August 2021. A total of 228 patients (64% female, 36% male) participated in a six-week psychiatric rehabilitation program to assess the impact of an adapted MSC training program compared to the control intervention of Progressive Muscle Relaxation training (PMR) on psychological well-being. Both training programs took place once a week for 75 minutes as part of a standardized inpatient rehabilitation program. The participants completed the Self-Compassion Scale (SCS), the Brief Symptom Inventory (BSI-18), and the Short-Form-Health-Survey-12 (SF-12) pre and post intervention.

At the moment, statistical analyses are being carried out. Detailed results will be presented on the poster.

The results of this study will contribute to rehabilitation research as they provide further insight into the role of MSC in the treatment of mental disorders. In addition, the clinical implications, and possible effects of changes in the rehabilitation program during the COVID-19 pandemic on the protocol and the results of this study will be discussed.

No significant relationships.

Over last decades convincing evident data was accumulated about the positive correlation of religious involvement and better mental health in depression, substance abuse, suicide, stress-related disorders and dementia. The studies of the impact of religion on patients with schizophrenia and schizoaffective disorders are still insufficient and controversial.

To investigate the impact of the religious coping strategies in patients with schizophrenia and shizoaffective disorder with focus on resolution and quality of remission in schizophrenia and schizoaffective disorder.

The pilot 1 year study covers 68 orthodox (group 1) and 55 unbeliever (group 2) outpatients with schizophrenia and schizoaffective disorder in remission on the maintenance therapy in FSBSI MHRC. The groups matched in age (18-60 y.o.), gender, treatment. The orthodox group received religious coping therapy. Number of relapses, remission quality (PANSS), quality of life (QLS), compliance (MARS) were measured 3 times (baseline visit, 6, 12 months). Statistical analysis (regression and correlation) was applied.

Religious coping strategies proposed by Paragment K. (2013) were applied considering the peculiarities of value-semantic structures and selected religious values of the patients as important rehabilitation resource (Kopeyko et al, 2016). Group 1 demonstrated statistically significant better remission at 12-months point – better subjective well-being, social/functional outcomes, higher adherence to medication, less relapses, less psychotic symptoms.

Religion contributes to acquire adaptive functions as the meaning of life, sense of hope, spiritual comfort, supports the overcome the disease burden. Religious coping is an important tool for rehabilitation and preventing the relapses in patients with schizophrenic disorders.

No significant relationships.

Cognitive impairments have a considerable impact on the functioning of patients, their socialization and level of disability. Cognitive deficits significantly deteriorate the quality of patients’ life. Currently, the possibilities of pharmacological correction of cognitive disorders in patients with epilepsy are limited.

Study of non-pharmacological program of cognitive disorder correction in patients with epilepsy and the assessment of its efficiency.

We have studied the features of clinical and psychopathological manifestations in patients suffering from epilepsy. The study included 146 patients with epilepsy (85 men and 61 women) who were receiving inpatient care. The following psychodiagnostic techniques were used: MOCA test, Mini Mult test, Münsterberg test, depression and Hamilton anxiety scale, quality of life scale. 63 patients received cognitive training online, of which 30 patients also used psychoeducation methods.

According to the MoCA findings, patients with epilepsy showed cognitive decline, the average score was 20.72, whereas healthy persons’ average score was 27.36. The Quality of Life Scale: the average rate among all examined persons was 69.45 out of 100, 78.60 were the results of healthy persons. In patients with PG1, who used cognitive training and psychoeducation the results of the MoCA test showed an improvement in cognitive functions (1.4, p <0.001) and increased subjective assessment of quality of life (2.77, p <0.05).

The study of the use of cognitive training and psychoeducation in patients with epilepsy for cognitive functions, quality of life resulted in a positive outcome. Cognitive online training is an encouraging area in the rehabilitation of patients with cognitive decline.

No significant relationships.

Personal Health Budget (PHB) has been provided to consumers with severe mental illness within a policy shift toward a person-tailored mental healthcare treatment based on individual unmet needs. PHB is an amount of money to support patient’s health and wellbeing needs, which is planned and agreed between patients and their local NHS team. It is not new money, but it may mean spending money differently so that patients can get the care that they need. However, evidence of beneficial effects of PHB is still scarce.

The aim of this study was to provide preliminary data on clinical and social benefits of adding PHB to a standard pharmacotherapy in patients with severe mental illness across a 24-month follow-up period.

137 individuals with severe mental illness (aged 18–50 years) were recruited in one of the adult mental health services of an Italian Department of Mental Health. They completed the Global Assessment of Functioning scale, the Health of the Nation Outcome Scale and the Brief Psychiatric Rating Scale. Friedman’s test for repeated measure was used to assess the longitudinal stability of functioning and clinical parameters. A linear regression analysis was also performed.

A significant decrease in all GAF scale, HoNOS and BPRS scores along the 24 months of follow-up was observed. Regression analysis results specifically showed a relevant association between a PHB multiaxial intervention and the longitudinal reduction in BPRS ‘Negative Symptoms’ and HoNOS ‘Social Problems’ subscores.

Our findings support the useful implementation of a PHB approach for severe mental illness patients within the Italian mental health service network.

No significant relationships.

Technology-based interventions (TBIs), including computer and Internet-based interventions, mobile interventions, health applications, social media interventions, and interventions using technological devices, could become a useful, effective, accessible, and cost-effective approach (Berry et al., 2016; Firth, 2016) to complement conventional interventions for psychosis

to compare TBIs with conventional interventions for psychosis, focusing mainly on functioning and quality of life.

The systematic review preceding this work was based on 58 RCT of TBIs for psychosis. We selected the studies that analyzed functioning (N = 23) and quality of life (N = 15). We calculated the standardized mean change (SMC) and applied a three-level model because there were several effect sizes within the same study.

There were significant differences between TBIs and conventional interventions for functioning (d = 0.25, SE = 0.09, z = 2.72, p = <.01), but not for quality of life (d = 0.14, SE = 0.08, z = 1.78, p = .076) in patients with psychosis.

On average, patients who received TBIs performed better in functioning, but not in quality of life. Functioning is impaired in patients with psychosis, so TBIs should be considered a complement and efficacious intervention, highlighting the power of these type of interventions in improving some outcomes.

No significant relationships.

First-episode psychosis is a critical period for early interventions to reduce the risk of poor outcomes and relapse as much as possible. There are now many studies revealing the patterns of course in the short and medium terms, but uncertainties about the long-term outcomes of symptomatology remain to be ascertained.

First, we ascertained whether the structure of psychopathological symptoms, dimensions and domains of psychopathology remains invariant over time between first-episode psychosis and long-term follow-up. Second, we analysed the changes in the interrelationships of psychopathological symptoms, dimensions and domains of psychopathology between FEP and long-term follow-up at three levels.

We performed network analysis to investigate first-episode and long-term stages of psychosis at three levels of analysis: micro, meso and macro. The sample was a cohort of 510 patients with first-episode psychoses from the SEGPEP study, who were reassessed at the long-term follow-up (n = 243). We used the Comprehensive Assessment of Symptoms and History (CASH) for their assessments.

Our results showed a similar pattern of clustering between first episodes and long-term follow-up in seven psychopathological dimensions at the micro level, 3 and 4 dimensions at the meso level, and one at the macro level. They also revealed significant differences between first-episode and long-term network structure and centrality measures at the three levels.

Our findings suggest that disorganization symptoms have more influence in long-term stabilized patients. The main results of the current study add evidence to the hierarchical, dimensional and longitudinal structuring of first-episode psychoses.

No significant relationships.

Schizophrenia is heterogeneous in terms of symptoms and outcome, but neurobiology of this heterogeneity is not well-studied. Local correlation analysis of fMRI data provides a measure of local coherence, i.e., average correlation between BOLD-signal in a voxel and its neighbours. Local correlation is a promising approach, and it seems important to find links between local brain coherence and schizophrenia outcome.

We aimed to compare brain local coherence between schizophrenia patients with varied long-term outcomes and healthy controls (HC).

Patients with chronic schizophrenia spectrum disorders (37 males, mean age 41.5±5.5) and HC (17 males, mean age 38±7.7) underwent resting-state fMRI (3T). Cluster analysis based on PANSS and PSP allowed us to allocate patients into two subgroups (N = 13/24). The second subgroup had significantly more marked negative and general psychopathology symptoms and worse functioning than the first subgroup. Local coherence in the brain was compared between clinical subgroups and HC (ANOVA, p<.001 voxelwise, p[FDR]<.05 clusterwise).

Local coherence in the paracingulate gyri bilaterally ({-2; 58; 14}; 2712 mm3) differentiated the groups. Post hoc analysis revealed decreased local coherence in the subgroup with poorer outcome compared to HC, along with the absence of differences between the subgroup with better outcome and HC. There were no differences between clinical subgroups.

Hypoactivity of the cingulate cortex is related to negative symptoms (Bersani et al., 2014). Their severity, in turn, is strongly associated with outcome. Thus, local coherence in the cingulate cortex may be one of the factors which underlie outcome heterogeneity.

No significant relationships.

There is evidence that metabolic syndrome (MetS) is common in chronic psychosis but also exists in the early stages.

To study the prevalence and course of MetS over a period of 2 year after a first episode psychosis. To determine whether there may be differences in its prevalence according to the type of antipsychotic used over two years.

A sample of 300 patients participate in the PEPsNa Early Intervention Programme. SMet was determined at baseline and at 6, 12, 18 and 24 months. The type of antipsychotic used at each assessment moment is collected (none, aripiprazole, paliperidone, others). Adult Treatment Panel III (ATP III) criteria were used to define MetS.

The prevalence of MetS at baseline is 4.44% and increases to 7.96% at 6 months, 10.1% at 12 months, 8.62% at 18 months and 9.01% at 24 months. The prevalence of MetS increases at 6 (p<0.021) and 12 months (p<0.003) compared to baseline and then remains stable. Only at 6 months assessment there are significant differences (F-Ficher p<0.022) in the presence of MetS (15.8%) in the paliperidone group treatment (oral or LAI).

Metabolic syndrome (MetS) exists from the early stages of psychosis and increases in the first 6-12 months and remains stable thereafter. The type of antipsychotic treatment only seems to have an influence at 6 months, with no differences at other follow-up times.

No significant relationships.

Schizophrenia is essentially related to one’s self-perception and the relationship to the world. One possible explanation for symptoms of schizophrenia in activities is the disruption of timing, which can develop into a disorder of activity perception and attribution.

Our study aimed to investigate the specificity of time perception disorder within the schizophrenia-bipolar spectrum, within the time interval around one second.

In the study, N = 15 schizophrenic (M = 37.28 years, SD = 9.49 years), N = 9 bipolar (M = 49.44 years, SD = 8.48 years), N = 10 schizoaffective (M = 41.32 years, SD = 10.75 years) patients with compensated clinical condition and N = 28 healthy control subjects (M = 36.5 years, SD = 9.9 years) participated. Time processing was examined with a perceptual (discrimination) and a productive (synchronization) task.

Concerning the interval discrimination, patients with schizophrenia and schizoaffective disorder lag behind controls in the majority of indicators (0.373–0.772). In terms of production and reproduction, the deviation of schizoaffective patients indicates a moderate difference, but subjects with schizophrenia show a large effect size, and subjects with bipolar disorder demonstrate a small effect size.

Our results suggest that the schizophrenic group exhibits a comprehensive time-processing disorder and in this respect can be distinguished from the bipolar affective and the control group. People with schizoaffective disorder show an intermediate performance in reproduction between the schizophrenic and bipolar groups, while in the case of discrimination deficit, they approach schizophrenics.

No significant relationships.

Social phobia is frequent comorbidity in schizophrenia. It`s clinical correlates and consequencies for clinical practice in late-onset schizophrenia (LoS) are unclear.

The study aimed to compare clinical correlates and therapeutic options in LoS patient with and without social phobia.

16 LoS patients with social phobia (ICD-11 diagnosis, age 59,6±6,2, 25% males) were compared with 16 LoS patients without social phobia (69,9±10,9, 0% males). Results of clinical assessment (PANSS, HDRS-17), cognitive examination (MMSE, MoCA), CT data were analysed. Type of antipsychotics (conventional\conconventional) was registed, dose of antipsychotics and antidepressants was randed from 1 (low) to 3 (high). Mann-Whitney test and χ2statistic was used.

There was no group differences in age, age manifestation, illness duration, number of psychotic episodes, PANSS and HADRS scores, rates results of cognitive tests, atrophy scores, length of hospital state, types of received antipsychotics. LoS patients with social phobia received more frequently medium and high doses of antipsychotics than LoS patient without social phobia (χ2 (2)=6,432, p=0,040).

Increased doses of antypsychotics in patients with social phobia don`t correlate with severity of psychotic symptoms and nay reflect some treatment resistance as well as misinterpretation of symptoms of social phobia as insufficient retreat of the psychosis. Active detection of social phobia is significant for treatment optimization.

No significant relationships.

Schizophrenia is a chronic mental illness with unclear etiology. It is characterized by symptoms in various psychopathological domains (e.g. positive, negative). One of the concepts explaining the etiology of schizophrenia is the disconnection hypothesis. It assumes the existence of structural and functional disorders within the connections of brain regions. White matter is largely responsible for the quality of these connections. One of the important structures of white matter is the superior longitudinal fascicle (SLF) which connects many cortical structures.

The main aim of our study was to search for a relationship between the integrity of SLF and various psychopathological dimensions among schizophrenia patients.

42 schizophrenia subjects (SS) and 32 healthy controls (HC) participated in the study. All study participants underwent DTI-MRI analysis. The psychopathology of SS was assessed using the Positive and Negative Syndrome Scale (PANSS). In the study, we used the PANSS dimensions proposed by Shafer. Then, the SLF analysis was performed using fractional anisotropy (FA) and mean diffusivity (MD) parameters.

The differences in FA and MD values in SLF bilaterally between groups were confirmed. A correlation was found between MD values in left SLF and positive symptoms (p = 0.040) and excitement (p = 0.012). A correlation was found between the MD values in the right SLF and the symptoms of disorganization (p <0.000) and excitement (p = 0.004).

SLF seems to play a role in the etiopathogenesis of schizophrenia. Disturbed SLF integrity may be involved in the development of positive, disorganization and excitement symptoms.

No significant relationships.

Known risk factors for developing of first-time psychosis in patients with deep brain stimulator (DBS) include older age, short time after implant placement and cerebral target for stimulation. In particular, stimulation of subtalamic nucleus and globus pallidus internus has been shown to elicit psychotic symptoms in various case reports. To date, there are no cases describing onset of psychosis due to DBS in the ventralis intermediate nucleus (Vim) of the thalamus.

Case describtion of psychotic episode provoked by DBS in Vim region

Case report of 70 y.o. female with unilateral DBS from 2012 in Vim for essential tremor, who developed therapy resistant psychotic symptoms right after adjusted settings of the DBS.

Psychotic onset of otherwise healthy 70 y.o. patient occurred and gradually worsened after adjustment of DBS settings in absence of other iatrogenic factors, including medication and comorbidity, and required involuntary hospitalization one week after beginning of psychosis. Treatment after hospitalization comprised olanzapine 10 mg. 1dd1 did not cause resolvent of psychosis. Because of therapy resistance to psychofarmaca and worsening of psychotic symptoms, by way of exception neurologists had to change the settings back to basic leading to complete and sustained remission of psychosis within two days.

Among side effects of DBS in Vim, psychotic symptoms have never been reported. However, as in our patient, psychosis occurred after changes of settings in DBS and presented acutely, was severe, resulted in involuntary hospitalization and was therapy resistant. Pathophysiology of DBS-induced psychosis in Vim region is not known and requires further investigation.

No significant relationships.

Obesity has increased worldwide and concerns comorbidity in patients with schizophrenia, and is linked to a high mortality rate in this group. Although bariatric surgery is the gold standard treatment for refractory obesity, it rarely is indicated for subjects with schizophrenia due to psychotic symptoms recurrence.

Report weight-loss outcome and psychopathology changes over 36 months follow-up of 5 patients with schizophrenia submitted to bariatric surgery.

Patients have been followed for 36 months. Clinical and anthropometric assessments such as percentage of excess weight loss (EWL) and body mass index (BMI) have been performed at 6, 12, 24, and 36 months follow-up. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychopathology status. Wilcoxon test was used to assess statistical differences.

The sample included four female and one male subject, with BMI at baseline 42,81± 5,66. The results of BMI and EWL over time are described in Table 1. A significant statistical difference was found between BMI at baseline and at T6, T12, T24, and T36 (p<0,05). EWL was higher at T12 ( compared with T6), but not different from other measurements. PANSS scores at the baseline were 7,7 ± 1,6 for a positive domain, 8,7 ± 2,3 for a negative domain, and 19,2 ± 6 for general psychopathology, with no statistically significant differences during the follow-up.

Despite the small sample, bariatric surgery has been shown a safe and efficient refractory obesity treatment in patients with schizophrenia.

No significant relationships.

The Interpersonal Needs Questionnaire (INQ-15) and the Acquired Capability for Suicide Scale - Fearlessness About Death (ACSS-FAD) have been introduced to evaluate the theoretical constructs posit by Joiner’s Interpersonal Psychological Theory of Suicide (IPTS).

The present study aimed to evaluate the psychometric properties of the INQ-15 (which measures Thwarted Belongingness, TB, and Perceived Burdensomeness, PB) and the ACSS-FAD (measurement of Fearlessness About Death, FAD, dimension of the acquired capability) in a population of Italian university students.

Since there was no Italian version of the ACSS-FAD, we have translated it through an accurate multistage procedure. ACSS-FAD and INQ-15 have been administered to a sample of 1,665 Italian university students. We analyzed the factorial structure of the INQ-15 and the ACSS-FAD, their reliability, criterion, convergent and discriminant validity.

Principal Component Analysis confirmed a two-dimensional structure for INQ-15 and a one-factor structure for ACSS-FAD. Internal consistency reliability of the scales was good, respectively TB: α = .85; PB: α = .90; and FAD: α = .85. The INQ-15 demonstrated concurrent associations with suicidal ideation, while the ACSS-FAD with a history of suicidal planning/suicide attempt. Convergent and discriminant validity were also in line with previous studies.

Both INQ-15 and ACSS-FAD appropriately capture the respective constructs, proving to be valid measures for the assessment of suicide risk factors among Italian university students according to the IPTS. The valuable psychometric properties of the two scales established with this study in the Italian context encourages their use to advance the clinical understanding and prevention of suicide.

No significant relationships.

Previous research highlighted that adolescents with attention-deficit/hyperactivity disorder (ADHD) are four times as vulnerable to suicidal behavior as the healthy population. Maladaptive perfectionism is also viewed as an important risk factor for suicide. Yet, there are no studies which focused on the relationship between perfectionism and suicide among adolescents with ADHD.

The objective of the present study was to explore if perfectionism may be a risk factor for suicidal behavior in adolescents with ADHD.

The clinical group was recruited from outpatient clinics, while the non-clinical group was recruited from high schools around Hungary. The clinical group’s inclusion criterion was ADHD diagnoses, while the non-clinical group required the absence of any current or past psychiatric treatment or diagnoses.

In the ADHD group 88 adolescents participated, and 96 adolescents participated in the non-clinical group. There was no difference regarding the level of perfectionism in the groups, except one dimension of perfectionism, which is ‘Organization’. The ADHD group had significantly higher level of suicidal behavior than the control group ((χ2 (1) = 11.222, p < .001, V = 0.25). Among the ADHD group adaptive perfectionism was significantly negatively correlated with suicidal behaviour.

Adolescents with ADHD did not have a different level of perfectionism than the healthy control group only in ‘Organization’ trait. This result could add to the therapeutic work with adolescents diagnosed with ADHD with underlining the importance to focus on organizational skills. The result highlights that adaptive perfectionism appears to be a protective factor against suicidality.

No significant relationships.

Self‑harm is an ‘act of self‑poisoning or self‑injury carried out by a person, irrespective of their motivation’. A history of self-harm is linked with suicide risk. A study in Pakistan found self-harm to be more common in young people with unemployment and interpersonal difficulties as common triggers. Expanding liaison psychiatry services leads to an earlier assessment of patients with self-harm.

To study the demographic and clinical variables of patients along with methods and precipitating factors of self-harm.

A retrospective chart review of patients presenting with self-harm seen as a part of liaison psychiatry from October 2018 to June 2021.

A total of 168 cases were seen of which 10 were excluded due to incomplete data. Of 158 cases gender split was roughly in the middle, with 49.4% males (n=78) and 50.6% females (n=80). The mean age of patients was 27.59 with a range of 12-70, 40.5% belonged to the age group of 20-29 (n=64) (Figure 1).

77.8% (n=123) had a past psychiatric history. The most common being depressive disorder 31.6% (n=50) and borderline personality disorder 30.4% (n=48). 35.4% of patients reportedly had previous attempts of self-harm. The most common methods being the use of sharp objects, rat-pill poisoning, and corrosive intake (Figure 2).

Conflicts with family and relationship difficulties were reported to be the most common precipitating factors.

Self-harm is a challenging and frequent presentation. Patients may present with diverse characteristics and varying needs. Hence physicians must be prepared for timely liaison and prompt management.

No significant relationships.

Suicide is the second leading cause of death (8.5% of all deaths) in adolescents. The search for neurobiological markers of suicidal behavior seems to be highly actual. Such markers may include quantitative EEG parameters and signs of neuroinflammation that plays an important role in the pathogenesis of various mental disorders.

The aim of the study was to reveal the relationships between pre-treatment clinical, EEG, and neuroimmunological parameters in depressive adolescents with suicidal attempts in their history.

35 female depressive patients (all right-handed, age 16–25, mean 18,7±2.9 years old) were enrolled in the study. Total HDRS-17 scores varied from 13 to 43 (mean 27,7±8.1). Multichannel resting EEG was recorded with spectral power (SP) measurements in narrow frequency sub-bands. Functional activities of leukocyte elastase (LE) and of its antagonist α1-proteinase inhibitor (α1-PI), as neuroinflammation markers, were measured in the blood plasma. Leukocyte/inhibitory index (LII=LE/α1-PI) was calculated. Spearman’s correlations between clinical, EEG, and neuroimmunological parameters were analyzed.

Sum of anxiety cluster of HDRS-17 scale (items 9, 10, 11) correlated positively (p<0.02) with LE and α1-PI values, as well as with theta1 (4-6 Hz) and theta2 (6-8 Hz) SP in EEG leads of the right hemisphere. In turn, α1-PI values correlated negatively and LII values correlated positively with alpha3 (11-13 Hz) SP in majority of EEG leads.

The data obtained confirm the contribution of neuroinflammation to clinical conditions, especially to anxiety level, and to EEG pattern in depressive female adolescents with suicidal attempts. The study supported by RBRF grant No.20-013-00129a.

No significant relationships.