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Psychopathology of schizophrenia in the context of the superior longitudinal fascicle integrity – a DTI study

Published online by Cambridge University Press:  01 September 2022

P. Podwalski ,
E. Tyburski ,
K. Szczygieł ,
A. Michalczyk ,
L. Sagan  and
J. Samochowiec
P. Podwalski*
Affiliation:
Pomeranian Medical University, Department Of Psychiatry, Szczecin, Poland
E. Tyburski
Affiliation:
Pomeranian Medical University, Department Of Psychiatry, Szczecin, Poland
K. Szczygieł
Affiliation:
Pomeranian Medical University, Department Of Psychiatry, Szczecin, Poland
A. Michalczyk
Affiliation:
Pomeranian Medical University, Department Of Psychiatry, Szczecin, Poland
L. Sagan
Affiliation:
Pomeranian Medical University,, Department Of Neurosurgery, Szczecin, Poland
J. Samochowiec
Affiliation:
Pomeranian Medical University, Department Of Psychiatry, Szczecin, Poland
*
*Corresponding author.

Abstract

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Introduction

Schizophrenia is a chronic mental illness with unclear etiology. It is characterized by symptoms in various psychopathological domains (e.g. positive, negative). One of the concepts explaining the etiology of schizophrenia is the disconnection hypothesis. It assumes the existence of structural and functional disorders within the connections of brain regions. White matter is largely responsible for the quality of these connections. One of the important structures of white matter is the superior longitudinal fascicle (SLF) which connects many cortical structures.

Objectives

The main aim of our study was to search for a relationship between the integrity of SLF and various psychopathological dimensions among schizophrenia patients.

Methods

42 schizophrenia subjects (SS) and 32 healthy controls (HC) participated in the study. All study participants underwent DTI-MRI analysis. The psychopathology of SS was assessed using the Positive and Negative Syndrome Scale (PANSS). In the study, we used the PANSS dimensions proposed by Shafer. Then, the SLF analysis was performed using fractional anisotropy (FA) and mean diffusivity (MD) parameters.

Results

The differences in FA and MD values in SLF bilaterally between groups were confirmed. A correlation was found between MD values in left SLF and positive symptoms (p = 0.040) and excitement (p = 0.012). A correlation was found between the MD values in the right SLF and the symptoms of disorganization (p <0.000) and excitement (p = 0.004).

Conclusions

SLF seems to play a role in the etiopathogenesis of schizophrenia. Disturbed SLF integrity may be involved in the development of positive, disorganization and excitement symptoms.

Disclosure

No significant relationships.

Keywords

DTINeuroimagingPsychopathologyschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S249
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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