Involuntary admissions are increasing in numbers across Europe.1 They can be traumatic for the patients2 and are associated with large societal costs.3 Individuals with psychotic disorder are at particularly elevated risk of involuntary admission.

This study aims to investigate whether machine learning methods including natural language processing can predict involuntary admission among patients with psychotic disorder.

We have obtained a dataset based on electronic health records for all patients having had at least one contact with the psychiatric services in the Central Denmark Region from 2011 to 2021. This dataset covers more than 120,000 patients, of which approximately 10,000 have been diagnosed with a psychotic disorder. The dataset contains both structured data, such as diagnoses, blood tests etc., as well as unstructured data (text). We will train machine learning models, basic logistic regression-models as well as state-of-the-art neural networks, to predict involuntary admission after contacts to the psychiatric services.

As the machine learning models are under development, no results are available at this time. Preliminary results are expected in spring 2022.

If involuntary admission can be predicted among patients with psychotic disorder based on data from electronic health records, it will pave the way for potentially preventive interventions. References: 1. Sheridans-Rains, L et al., 2019 2. Frueh, B.C et al., 2005 3. Smith,S., 2020

No significant relationships.

Better evaluation and understanding of the core symptoms have key importance both in clinical practice and the research of attention-deficit hyperactivity disorder (ADHD). One hallmark neurocognitive feature of ADHD is impaired inhibition, related to impulsivity. Given the high heritability of ADHD, the assessment of genetic background of impaired inhibition may contribute to our knowledge about the genetic background of the disorder.

In our study we investigated whether different forms of impulsivity (attentive, motor, and nonplanning) and polymorphisms in genes of the noradrenergic, serotonergic, and dopaminergic neurotransmission, i.e. dopamine transporter-1 (DAT1), cathecoloamin-O-metiltransferase (COMT), and serotonin receptor-1B (HTR1B genes show association.

208 aADHD patients diagnosed according to DSM-5 criteria from a clinical sample and 142 individuals from a population sample who screened positive for aADHD were included in the study. DNA samples were genotyped for the HTR-1B gene rs1321041 and the COMT gene rs4680 SNPs, moreover the DAT-1 VNTR polymorphism. Dimensional variables for impulsivity were compared between genotypes with the Generalized Linear Model procedure corrected for sex and age, using the PLINK 1.9 statistical software.

The 9 repeat polymorphism in DAT1 was associated with the severity of hyperactivity, moreover, all impulsivity factors. The A allele in COMT was associated with hyperactivity and better motor inhibition activity. In carriers of the G allele in HTR1B we detected significantly higher inattention scores and increased reaction time.

Our results support the putative role of the investigated genetic polymorphisms in the etiology of impulsivity. Nevertheless, these polymorphisms demonstrate a heterogeneous associations.

No significant relationships.

Pharmacogenetic (PGx) targets to optimize drug therapy, but its implementation is rare.

We evaluate the clinical utility of PGx testing in psychiatry by investigating the one-year risks of clinical outcomes in patients with depression taking sertraline, (es)citalopram or fluoxetine by their Cytochrome P450 (CYP) 2C19/2D6 phenotypes.

We investigated 17,297 individuals born between 1981-2005 with a depression diagnosis between 1996-2012 from the iPsych2012 case-cohort. Based on array-based single-nucleotide-polymorphism genotype data, individuals were phenotyped as CYP2C19/CYP2D6 normal (NM, reference group), ultra-rapid- (UM), rapid- (RM), intermediate- (IM), or poor-metabolizer (PM). Outcomes were treatment switching or discontinuation, psychiatric in-, out-, and emergency room contacts (ER), and suicide attempt/self-harm. Incidence rate ratios (IRR) by age groups were estimated using Poisson regression analysis with 95% confidence intervals, adjusted for potential confounders.

Risks of switching (IRR=1.89[1.22-2.93]), ERs (1.69 [1.01-2.81]) and suicide attempt/self-harm (2.73 [1.49-5.01]) were higher in CYP2C19 PMs <19 years taking (es)citalopram. Fluoxetine users <19 years had a decreased risk of discontinuation in CYP2D6 PMs (0.5 [0.27-0.95]) and decreased risk of out-patient contacts in CYP2D6 PMs and IMs (IRRIM=0.83 [0.68-1.00] and IRRPM=0.59 [ 0.37-0.96]). We observed an increased risk for ERs in CYP2D6 PMs aged 19-25 years taking fluoxetine (4.53 [1.54-13.35]). In CYP2C19 UMs >25 years taking (es)citalopram the risk of suicide attempt/self-harm was more than three-fold increased (3.64 [ 1.01-13.19]). We found no significant results in users of sertraline.

PGx variability was associated with treatment outcomes in depression in patients with CYP2C19 PM or UM status taking (es)citalopram, or CYP2D6 PM or IM status taking fluoxetine.

No significant relationships.

Catenin alpha 2 gene (CTNNA2) is important in the stability of hippocampal synapses and also in brain development. Our recent paper (Eszlari et al, Pharmaceuticals 2021, 14, 850) has demonstrated that rumination on sad mood mediates the association of CTNNA2 only towards psychiatric symptoms, but not towards cardiovascular risk phenotypes.

Our present aim was to test the moderating role of rumination and its two subtypes, brooding and reflection, in genetic associations between CTNNA2 and the same cardiovascular risk phenotypes.

633 unrelated subjects from the Budakalasz Health Examination Survey with non-missing phenotypic data, and 160 single-nucleotide CTNNA2 variants remaining after quality control, were included. Linear regression models were run in Plink 1.9 for separate outcomes of body mass index (BMI), and Framingham risk scores for cardiovascular disease, coronary heart disease, myocardial infarction, and stroke. With each variant, predictors were the variant, rumination or its subtype, the variant x rumination interaction, sex, age, and the top ten principal components of the genome. 100,000 label-swapping max(T) permutation was applied for the interaction term within each analysis.

While no significant interaction term survived the familywise permutation, two trends emerged. Namely, BMI seems to have positive association with rumination and its maladaptive brooding subtype only in case of GG genotype of rs13412541, otherwise no association can be detected.

Although replication is needed in larger samples, the relationship between rumination and BMI, conditional on CTNNA2 genotype, can be important in atypical depression, thus may contribute to stratification of depressed patients.

The study was supported by the New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (ÚNKP-21-4-II-SE-1); and by 2019-2.1.7-ERA-NET-2020-00005.

In major depressive disorder (MDD), reward-based decision-making (DM) is frequently impaired: e.g. patients don’t engage in pleasant activities as much as healthy subjects. Put differently, previous and expected future rewards have less reinforcing effects on DM. This study investigated two experimentally well-observable reward-based DM modes, namely model-based (based on cognitive models of the environment) and model-free (based on previous experience) DM.

We hypothesized that model-based training can improve reward-based DM in patients with MDD. Answers to these questions could enhance the development of cognitive-behavioral therapeutic interventions.

27 patients with MDD were recruited and assessed with psychometry. All patients performed the „two-step Markov decision-task“ (Daw, 2011), which allows the simultaneous investigation of model-based and model-free DM via computational modelling. All subjects performed the task 4 times: at the beginning and at the end of 2 assessment days (session-interval: 4 days). Subjects were randomly allocated to an intervention group, which performed model-based training, and a control group, which performed model-free training. The main outcomes of training effect were the influence of model-based reward expectations on decisions (quantified by computational modelling parameters) and overall monetary reward-success.

In all patients, the influence of model-based reward expectations on decisions increased after training. However, there was no significant effect of group allocation. Furthermore, patients in the intervention group did not achieve significantly higher overall monetary reward.

Results suggest that in MDD, the influence of model-based reward expectations on decisions can be improved regardless of specific training type. Future studies should investigate the effects on everyday functioning.

No significant relationships.

During the COVID-19 pandemic residents of the central region of Hungary also had to adapt to several challenges such as changes of hospitals’ specialty profiles and delegation of health care workers to COVID wards.

Hungarian residents have their practical training in various hospitals, while their psychiatric academic training is organised in groups.

Our aim is to share our personal experiences about how our work and training have changed during the pandemic and it’s effect on our patients.

Participants of the study were the authors of the poster. Responses to open questions were structured based on the following topics: competencies in internal medicine, infectious diseases and psychiatry, our collaboration with other medical disciplines, psychiatric training and attitudes towards mental health patients.

We worked min 2 weeks max 8 months at COVID wards and also treated COVID-19 infected psychiatric patients, thus gaining a greater experience in general medicine. In psychiatric work, acute care became prominent, communication in PPE and restricted contact with patients’ relatives were particularly difficult. Our relationship with other specialists has improved, consultation became easier. Increased use and misuse of psychiatric consultation requests led to further pressure. Restrictions, stigmatisation and discrimination increased against psychiatric patients, including difficult access to care. Psychiatric training in the hospitals became limited, however seminars organized by the university continued online with our active participation.

During the pandemic we gained greater experience in general medicine. Psychiatric care and our training was negatively affected, however the latter was mitigated by online seminars.

No significant relationships.

Generic psychometric instruments are frequently used in psychiatric practice. When a respondent provides an affirmative reply to two contrasting items in such a questionnaire (e.g. “I am reserved” and “I am outgoing”), serious questions need to be asked about the respondent, the instrument, and the interaction between the two.

The research aims to identify reasons which could explain the contradictory answers provided by respondents to a well-established, and seemingly psychometrically sound instrument.

World Values Survey data, collected in South Africa (N = 3 531), were analysed, focusing on the personality survey, where contrasting response to matching items were identified. Exploratory factor analyses were used to inspect the factorial structure of the instrument across groups, after which measurement invariance tests were done.

The theorised factorial structure of the personality survey did not mirror the structure in the South African sample. This was demonstrated in the inspection-report, as well as in the tests of measurement invariance. However, in some groups, specifically those who were well-versed in English and possessed higher levels of education, the structures were replaceable.

The assumption that well-established instruments are valid in settings different to the one where they were initially developed, should be questioned, and such instruments should not be used unless thoroughly tested. This presentation exposes the extent of measurement non-invariance when using an instrument in a foreign setting and shows how this can be detected and addressed. Those working with foreign individuals or conducting cross-cultural research should be particularly aware of these threats to validity.

No significant relationships.

Binge-eating disorder (BED), is one of the most common eating disorder. Treatment aims to reduce binge-eating frequency and disordered eating–related cognitions, improve metabolic health and weight, and regulate mood (in patients with coexisting depression or anxiety)

The aim of this study was to examine the efficacy of lisdexamfetamine dimesylate in a simple of 50 women with a binge eating disorder diagnosis compare with selective serotonin reuptake inhibitor

Two groups were made, one with lisdexamfetamine and the other with selective serotonin reuptake inhibitor (fluoxetine). 20 women were in each group (total n=40). The doses depend of the binge symptoms and rates were from 30 to 70md/day for lisdexamfetamine and for fluoxetine the doses were from 20 to 60mg/day.

Binge behaviors decreased with a 50mg/day dose of lisdexamfetamine. The 70mg/day doses present also less binge behaviors but also more adverse events. The 30mg/day doses did not decrease binge-eating behaviors.

Lisdexamfetamine is the first pharmacological agent to receive FDA approval for use in adults with moderate to severe binge eating disorder. This study supports further assessment of lisdexamfetamine as a treatment option for decreasing binge eating behavior and also symptoms associated such as anxiety and obsessive and compulsive features in adults.Increased efficacy with increasing dosages of lisdexamfetamine suggests a dose-response relationship until 50mg/day. Women with a dose of 50mg/day of lisdexamfetamine report less adverse event, more adherence to treatment and improve their eating behaviors.

No significant relationships.

ASD with epileptic seizures (ES) and/or specific epileptic activity on EEG (EEG SEA) and repetitive movements and vocalizations (RMV) can be determined by different variants of genetic polymorphism or by different variants of gene expression, determined by different influences.

To study the features of the clinical phenotype of ASD in preschool and school-age children with ES, EEG SEA and RMV.

: The study group was divided 116 children aged 2-10 years with ASD into three subgroups: subgroup A - 23 children with a history of ES, subgroup B - 35 children with EEG SEA without ES, subgroup C - 19 children with ASD having EEG SEA, RMV (motor stereotypes, motor tics and/or vocal tics). The control group consisted of 39 children with ASD non a history of ES and EEG SEA.

: Children with ASD, complicated by severe and frequent ES are charactered by impaired social reciprocity and communication against the background of regression / stagnation of speech and motor skills development (aOR: 2,7 [1,7-4,8]). Disoders of communication and repetitive behavior in ASD in children of different ages are represented by different monoqualitative syndrome (phenotypes). Movement stereotypes predominated in children with ASD without ES and without EEG SEA (aOR: [1,8-7,9]). In children with ASD and EEG SEA, motor stereotypes and repetitive behavior were equally common ([SD] 2.1 -1, P =0.81).

: Disorders of social reciprocity, communication, repetitive behavior are diagnostically significant for ASD complicated by ES, ASD with EEG SEA.

No significant relationships.

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common psychiatric disorders of childhood with significant impairment in overall functioning and associated psychiatric comorbidities. Knowledge of determinants is vital for the development of effective preventive strategies and tailor made interventions.

The study was aimed at determining risk factors for the development of ADHD among primary school children (PSC)) in state schools in Colombo district of Sri Lanka.

An unmatched case control study was conducted consisting of 73 cases (with ADHD) and 264 controls (without ADHD) selected randomly among 6-10 year old PSC from Sinhala medium state schools in Colombo district. Primary Care Givers completed the validated Sinhala version of Swanson, Nolan, Pelham –IV (SNAP-IV-S) scale for the assessment of ADHD and an interviewer administered questionnaire on risk factors. Children’s diagnostic status was confirmed by a Consultant Child and Adolescent Psychiatrist following a clinical assessment. Bivariate analysis followed by multivariate regression model identified potential risk factors.

Multivariate analysis revealed, male sex (aOR=3.74; 95%CI=1.67-8.35), lower educational level of the mother (aOR=3.31; 95%CI=1.39-7.98), maternal psycho pathology (aOR=7.28; 95%CI=1.55-34.35), prenatal exposure to passive tobacco smoke (aOR=3.76; 95%CI=1.09-12.95), Birth weight <2500g and /or gestation period of <37 completed weeks (aOR=3.6; 95%CI= 1.48-8.74), neonatal complications (aOR=4.03; 95%CI=1.94-8.32) , minimal leisure time with family (aOR=2.39; 95%CI=1.19-4.82) and subjected to teasing/ bullying (aOR=5.03; 95%CI=2.47-10.25) as significant predictors of ADHD.

Primary prevention focusing on strengthening neonatal, maternal and child health services needs highlighting together with special emphasis on the need for anti-bullying policies in state schools.

No significant relationships.

The specific learning disorders (SpLD) are neurology based development disorders which are characterized by significant difficulties in acquiring learning skills. SpLD are often accompanied by mental health problems because of emotional and behavioral consequences of the diagnosis. While the presence of SpLD can worsen psychological well-being among school aged children, resilience factors can neutralize these harmful effects.

The aim of this research is to identify protective factors promoting development of psychologial well-being and mental health in adolescents with SpLD compared to a control group of peers without this diagnosis.

Hungarian primary school students (N = 174; M = 13.34 years, SD = 1.14) participated in the study aged between 11 to 15 years. Of these, 23.6% students had a SpLD diagnosis. Participants completed a paper pencil-based questionnaire that included: EPOCH Psychological Well-being Questionnaires of Adolescent, WHO Well-being Index, Satisfaction With Life Scale, Multidimensional Perceived Social Support Scale, The Connor-Davidson Resilience Scale, and Self-regulation Scale.

Psychological well-being in both groups shows positive correlation (p<0.01) with general well-being, satisfaction with life, social support, self-esteem and self-control. In the SpLD group, the engagement and connectedness subscales do not relate to the general well-being and life satisfaction, in contrast with the control group in which these are associated with both. Self-control shows stronger correlation with general well-being and with engagement and connectedness subscales as compared to the control group (p<0.01).

There are differences in contributing factors of general psychological well-being in adolescents with SpLD and those without this diagnosis.

No significant relationships.

Despite the fact that 95% of all <5 years of age children with developmental disabilities including Autism Spectrum Disorders (ASD) live in low- and middle-income countries (LAMI), to date there is an information gap in LAMI studies including Republic of Georgia.

To estimate the prevalence and describe the clinical characteristics of ASDs among the third-grade school students using a total population approach.

The target population (N=27,336) included all 3rd grade students of schools of five main cities of Georgia. The study was conducted in four steps: phase I screening, sampling of screen positive students, phase II confirmative diagnostic assessment, and best-estimate diagnosis. Parents and teachers completed two screening questionnaires in phase I: 27-item Autism Spectrum Screening Questionnaire (ASSQ) and 25-item Strengths and Difficulties Questionnaire (SDQ). In phase II, screen-positive children were evaluated using standardized diagnostic assessments.

Overall, 16,654 students (82%) were assessed by either parent and/or teacher. Students whose ASSQ and/or SDQ scores were in the top 10th percentile were considered as screened positive for diagnostic assessment (N=1976). Of 300 students completed diagnostic assessment 53 were diagnosed ASD. Crude prevalence of ASDs was estimated to be 4.5%. 75% of cases of ASD were first diagnosed. Efforts are currently underway to compute adjusted prevalence, which will be available for the Conference presentation.

The prevalence data of ASD is important to assess the burden of the disorder and facilitate better understanding of specifics of the disorder in different part of the world.

No significant relationships.

The maladaptive children behavior analysis is important for determining effective methods of prevention and care.

The aim of the study was to identify general and gender-specific features of maladaptive behavior in children of primary school age with disabilities.

The sample included 77 children 8.6±1.03 years of age, among them 57 boys and 20 girls. Maladaptive children behavior was assessed using VABS. The statistical significance of the differences between variables was determined by Pearson`s Chi-squared test. Indicators of maladaptive behavior were assessed by calculation of frequency distribution and contingency tables.

Maladaptive behavior features common for both genders included impulsivity, physical aggression, taunting, teasing and bullying, insensitivity to others, having poor eye contact. Having a hard time paying attention was statistically significantly more common among boys (p≤0.05). Boys were more likely to disobey and defy those in authority, to lie, cheat or steal. A specific feature of maladaptive behavior for girls was having eating difficulties and overly dependent behavior on caregivers or siblings. Comparative analysis of the additional VABS section results showed that obsession with thoughts or activities predominated among boys, as well as expression of thoughts that do not make sense. The following indicators were found only in boys: strange habits or ways (makes repetitive noises, odd hand movements, etc.) (14%), bizarre speech (conversations with self in public, repeating the same word or phrase, etc.) (7%).

Described signs of children’s maladjustment can be used for the purposes of diagnostics, prevention and care.

No significant relationships.

Young people moving from adolescent secure inpatient units to adult care in the UK present with multiple and complex needs and are more likely to experience poor transition outcomes related to enduring dependency on mental health services. However, there is lack of knowledge about the feasibility of transitional care models improving transition outcomes.

The MOVING FORWARD study aims to implement a new transition intervention model for young people transitioning from adolescent secure services to adult-oriented settings and test the feasibility of a future cluster trial measuring its effectiveness.

The design of the study is a three-arm feasibility, cluster randomised controlled trial comparing the MOVING FORWARD intervention against standard transition preparation in six adolescent secure services.Young people between 17-19 years, their parents/carers and key workers will be allocated in two conditions and will receive four transition preparation workshops across six months. Data will be collected at three time points: (T0) baseline, (T1) 6-12 months post-intervention, and (T2)18-24 months post-baseline.

Thirteen young people and 17 staff members have contributed to the intervention design through online Advisory Groups. Common identified themes included appropriateness of module content and support during delayed transitions. An intra-class correlation coefficient will be calculated to inform the power of sample size. With a sample size of 50, we will be able to estimate a drop-out rate of 80%.

This research will provide practitioners and policy makers with an evidence-based framework about barriers and facilitators to the proposed intervention and will enable services to reflect on quality of transitional care delivery.

No significant relationships.

Previously, we conducted a statistical case-control study of adolescent Hikikomori patients in Japan using the Parental Assessment of Psychological, Behavioral and Environment Scales. That study did not reveal any pathologies specific to Hikikomori patients. On the other hand, environmental factors such as “lack of communication between parents” and “overuse of the Internet” were shown to be significant predictors of Hikikomori severity.

In this study, using the same methodology as our previous study in Japan, we conducted a case-control study in France. The following questions were examined : (1) whether the pathology of Hikikomori patients in Japan and France is the same, and (2) whether the environmental factors associated with the severity of Hikikomori are the same in Japan and France.

Using CBCL and our original scales, we descriptive-statistically compared clinical and subclinical psycho-behavioral characteristics of adolescent Hikikomori patients and a control group. In addition, environmental factors that make Hikikomori more severe were clarified by multiple regression analysis.

The results showed that there was no difference in the pathology of Hikikomori between Japan and France. On the other hand, the statistical predictors of Hikikomori severity were “lack of communication between parents and children” and “Lack of communication with the community,” which differed from those in Japan.

Although it is safe to assume that Japanese and French Hikikomori’s pathology is generally the same, different strategies may be needed to prevent the onset of Hikikomori and to stop it from becoming severe.

No significant relationships.

Post-traumatic stress disorder (PTSD), is a Mental Health condition due to a traumatic experience. There are four types of Gender Violence in Latin America: physical, sexual, psychological or patrimonial violence, when it occurs between intimate partners it is called intimate partner violence (IPV). PTSD is highly associated with IPV.

Determine the statistical index of IPV and PTSD in women and men in Guayaquil-Ecuador.

We carried out a descriptive cross-sectional study, the sample was collected at the Florida Prosecutor’s Office in Guayaquil-Ecuador by UCSG medical students in 2018. The sample was 239 individuals, 195 women, 44 men. Individuals were separated into groups by gender, marital status, children, age, habits and PTSD. We applied Beck test for Depression, Davidson and DSM-5 for PTSD.

In this study we observe a male population suffering from IPV. Complaints of IPV 195 women (81.59%), 44 men (18.41%). PTSD positive 159 women (81.96%), men 35 (18.04%). More prevalent in age ranges 25-34. PTSD with children 147 (76%) and without children 47 (24%).

Factors such as being a woman, having children and younger ages are linked in this study as predisposing to suffer from IPV and PTSD. We highlight a male population that reports suffering from IPV despite the lack of support, especially in Latin America. It is worth mentioning that the final consequence in many cases is femicide and homicide. Although IPV is serious and frequent, Medical professionals still do not focus on IPV diagnosis, therefore affected individuals don t receive support.

No significant relationships.

About 15% of women experience a depressive episode during pregnancy, and 19% during the postpartum. Studies on safety of Antidepressants use during pregnancy have given controversial results. Obstetric-gynecological changes of pregnancy determine modifications in the pharmacokinetics of medications, through an altered metabolism of the CYP enzymes. Patient’s therapeutic response might also be influenced by polymorphisms of the genes encoding CYP enzymes.

In this perspective, we evaluated the correlation between pharmacokinetics, pharmacogenetics and psychopathological measures, analyzing SSRIs or SNRIs concentrations during the three trimesters of pregnancy, at birth and at postpartum, in order to define efficacy, tolerability and safety of Antidepressants (ADs) in the treatment of affective and anxiety disorders during pregnancy.

87 patients were enrolled at the Depressive Disorders Treatment Centre (CTDD) of the Department of Psychiatry of Sacco University Hospital (Milano, Italy). Plasma concentrations of ADs were measured during first (T1), second (T2), third (T3) trimester, at birth (T4) and at postpartum (T5). Psychometric assessments were carried out. The genotype of hepatic CYP isoforms were also analysed.

ADs mainly metabolized by CYP2C19 (es. Sertraline) are less frequently below therapeutic range than ADs metabolized by CYP2D6. In fact, the metabolic activity of CYP2C19 is slowed down during pregnancy. The majority of ADs concentrations below therapeutic range were found in women with an accelerated metaboslism, carrier of a CYP polymorphism.

Our results underline that the systematic use of pharmacokinetic and pharmacogenetic analyses during pregnancy could constitute a valid support in the management of therapy in the last phases of pregnancy.

No significant relationships.

Mothers of terminally ill children experience chronic stress that can lead to physical and emotional exhaustion. A better understanding of their experiences, resources, and vulnerabilities can help plan psychological interventions.

The research is aimed to study mothers’ appraisals of their life situation related to the child’s terminal illness and their coping strategies.

Participants: 21 women (aged 26-49) whose children were patients at the hospice. Women answered a set of open-ended questions and completed questionnaires: “Appraisal Criteria of the Difficulty of a Life Situation”, “Types of Orientations in Difficult Situation”, “Ways of Coping Checklist”. Data were analyzed with Pearson’s r.

Planned coping was associated with evaluations of opportunity (r=0.78) and threat to the future (r=0.61). Despite the deteriorating health status of most of the children, women reported a high degree of subjective control. This might be related to outside help. Participants stated that helping by the family, doctors, and psychologists was essential. Unexpectedly, the “need for a quick and active response” score correlates with that for the coping strategy “fantasizing” (r=0.62). This can be explained by the depletion of resources; deprivation of sleep and active rest is often observed. An important feature is that half of the participants report high self-blame.

We suggest that self-blame, an analysis of opportunities, and probable future scenarios are important psychotherapy targets for mothers of terminally ill children. The consequences of threat appraisal are twofold: admitting the threat can be painful, but it also mobilizes one’s energy. Funding: The study was funded by RFBR, project number 20-013-00838.

No significant relationships.

The fact of emergence of a child with special needs in a family is followed by intensive emotional reaction of the parents. One of the pronounced feelings in those circumstances is the sense of guilt.

The research aim is studying the emotional experience of mothers of children with special needs connected with the sense of guilt and the characteristics of the parent-child relationship in such families.

The research sample includes 25 mothers of children with special needs in the age from 3 to 10 years old with the diagnosis ASD, cerebral palsy and epilepsy as well as 29 mothers of normally developing children of the same age. Research methods: Guilt Inventory (Jones &Kugler); Inventory of Parental Attitude (Varga &Stolin); Inventory of the Parent’s Psychological Type(Tkacheva).

The mothers of children with special needs show the more pronounced sense of guilt comparing with the mothers of the healthy children. They are less optimistic towards the future of the child, more sensible to the failures of the child, but demonstrate the higher degree of readiness to cooperation with the child. Those results can be applied when designing the intervention programs for the families of children with special needs.

Those results can be applied when designing the intervention programs for the families of children with special needs.

No significant relationships.

Pseudocyesis and Delusion of Pregnancy are often conflated. Both presentations are associated with false beliefs of pregnancy in patients who are not pregnant. Pseudocyesis is associated with physiological changes of pregnancy such as amenorrhea, galactorrhea, abdominal distention, and hyperprolactinemia. Delusion of Pregnancy is not associated with physiological signs/changes. We describe a case to demonstrate the phenomenological and physiological differences between these entities and how these influence treatment considerations.

1.Phenomenology of Pseudocyesis vs Delusion of Pregnancy 2.Elucidate the physiological underpinnings of both 3.Treatment considerations

Comprehensive literature review following a 29-year-old-female with no known psychiatric history presenting to the emergency department with mixed complaints of twin-pregnancy, menorrhagia, and concern for threatened abortion. Psychiatry was consulted for decisional capacity to leave against-medical-advice due to concerns for ectopic pregnancy. Patient reported a recent ultrasound with fetal heartbeat and sensation of fetal “kicks”. She was concerned the menorrhagia was threatening her pregnancy. The patient appeared irritable, paranoid, endorsed ideas of reference and a fixed false belief that she was pregnant with twins, despite quantitative HCG, abdominal and transvaginal ultrasounds being negative. On examination, while there was vaginal bleeding, there were no stigmata of pregnancy.

Diagnosis- Delusion of Pregnancy.

Delusion of Pregnancy have been associated with polythematic content. Pseudocyesis may be confounded by conditions such as abdominal neoplasms, leiomyoma, and endocrinologic changes (eg- hyperprolactinemia). Potent D2R antagonists carry increased risk of hyperprolactinemia and subsequent galactorrhea which may paradoxically exacerbate misattributions of pregnancy. Careful consideration of psychotropic choice is therefore needed in the management of these conditions.

No significant relationships.