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Bariatric surgery as a treatment for refractory obesity in patients with schizophrenia. Weight-loss outcomes and safety in 36 months follow-up

Published online by Cambridge University Press:  01 September 2022

P. Lorencetti ,
E. Chaim ,
E. Cazzo ,
A. Junior  and
P. Dalgalarrondo
P. Lorencetti*
Affiliation:
State University of Campinas, Psychiatry Department, Campinas, Brazil
E. Chaim
Affiliation:
State University of Campinas, Surgery Department, Campinas, Brazil
E. Cazzo
Affiliation:
State University of Campinas, Surgery Department, Campinas, Brazil
A. Junior
Affiliation:
State University of Campinas, Psychiatry Department, Campinas, Brazil
P. Dalgalarrondo
Affiliation:
State University of Campinas, Psychiatry Department, Campinas, Brazil
*
*Corresponding author.

Abstract

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Introduction

Obesity has increased worldwide and concerns comorbidity in patients with schizophrenia, and is linked to a high mortality rate in this group. Although bariatric surgery is the gold standard treatment for refractory obesity, it rarely is indicated for subjects with schizophrenia due to psychotic symptoms recurrence.

Objectives

Report weight-loss outcome and psychopathology changes over 36 months follow-up of 5 patients with schizophrenia submitted to bariatric surgery.

Methods

Patients have been followed for 36 months. Clinical and anthropometric assessments such as percentage of excess weight loss (EWL) and body mass index (BMI) have been performed at 6, 12, 24, and 36 months follow-up. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychopathology status. Wilcoxon test was used to assess statistical differences.

Results

The sample included four female and one male subject, with BMI at baseline 42,81± 5,66. The results of BMI and EWL over time are described in Table 1. A significant statistical difference was found between BMI at baseline and at T6, T12, T24, and T36 (p<0,05). EWL was higher at T12 ( compared with T6), but not different from other measurements. PANSS scores at the baseline were 7,7 ± 1,6 for a positive domain, 8,7 ± 2,3 for a negative domain, and 19,2 ± 6 for general psychopathology, with no statistically significant differences during the follow-up.

Conclusions

Despite the small sample, bariatric surgery has been shown a safe and efficient refractory obesity treatment in patients with schizophrenia.

Disclosure

No significant relationships.

Keywords

bariatric surgeryobesityschizophrénia
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S249 - S250
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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