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Agalope oshikirii n. sp. (Zygaenidae, Chalcosiinae) is described from the uppermost Miocene–Pliocene Sanzugawa Formation in Akita Prefecture, northern Japan. Because we found a single fossil forewing in this study, we give a table of the forewing characters of various groups of the genus Agalope and related genera and compared them with this new species, confirming that it does not match any of the species. This is the first discovery of chalcosiine fossils in Japan and provides evidence of a historically broader distribution of the genus.
What shapes the ways in which citizens participate in politics? This article investigates the association between private homeownership and the forms of citizens’ political behaviors using a Chinese nationwide social survey. Exploiting the abolishment of the welfare housing system in the late 1990s as a quasi-natural experiment, I find that owning a home and experiencing home value appreciation increases citizens’ willingness for political engagement as well as participatory behaviors through formal channels, but reduces their confrontational behaviors towards government such as participation in protests. Further evidence on political attitudes suggests that homeowners are more critical of government performance, yet they report higher political trust in the state and a stronger preference for maintaining the status quo. These findings highlight the critical role of asset ownership in preventing conflict and promoting stability by shaping the political behaviors and beliefs of citizens.
This paper examines the effect of the 2022 FIFA World Cup group matches on outgroup bias among South Koreans. Using a list experiment conducted in four rounds before and during the tournament, we investigate whether these matches promote social learning, enabling individuals to update their perceptions of outgroups directly involved in the match, or if they merely trigger emotional responses to match results, with defeats leading to increased outgroup bias regardless of match contact. Our findings suggest insufficient evidence to conclude that South Korean respondents generally modify their outgroup bias levels in response to these events. However, certain subgroups, particularly males, demonstrate strong reactions to losses, exhibiting heightened outgroup bias towards all outgroups. These results indicate that in the context of negative contact valence, high-stakes intergroup sports competitions can lead to an overgeneralized outgroup bias against various groups among highly engaged individuals. This study contributes to understanding the relationship between sports events and intergroup attitudes, highlighting the potential for negative outcomes to exacerbate biases among certain subpopulations.
Species of Monopteria are revised to include documentation of substantial change in shell shape during growth, characters of the hinge, and characters present on the anterior surface of the shell. The mature shell grew in an arcuate curve that elongates far to the posterior and has a wide sinus that separates the inflated shell body from a prong-like posterior auricle on the hinge line. An unusual depression of the paired valves (anterior depression) is present on the anterior surface surrounding a large byssal notch. Dentition is lacking, and a clinovincular ligament (new term) is present. Species occur mostly in mollusk-rich biotas of shallow marine environments. Species lived with a combination of byssal attachment and a rounded ventral surface that enabled them to maintain position within fine-grained sediment. Six species are recognized, and five are provided with new or revised descriptions. New species include M. magna and M. heaneyi, neotypes are designated for M. longispina Cox, 1857 and M. alata Beede, 1898, and a lectotype is designated for M. marian White, 1874. Species Gervillia auricula Stevens, 1858, and Anthracoptera polita White, 1880, previously considered to be included in the genus, are excluded from Monopteria and the name Gervillia auricula is judged to be without merit and abandoned. The use of genus name Limopteria as a replacement of Monopteria is shown to be invalid. Limopteria is not a valid name; it has never been proposed as a taxon in publication.
The Edgerton crown is an iconic manifestation of drop impact splashing, with its prominent cylindrical edge decorated with detaching droplets. Herein, we identify the formation of an intriguing double-crown, when a high-viscosity drop impacts on a shallow pool of a lower-viscosity immiscible liquid. High-speed imaging shows that after the initial fine horizontal ejecta sheet, the first inner crown emerges vertically from the film liquid. This is followed by the second crown which forms near the outer base of the first crown, as the tip of the horizontally spreading viscous drop approaches the outer free surface. Axisymmetric numerical simulations, using the volume-of-fluid method with adaptive grid refinement, show that the flow squeezed out between the viscous drop and the solid surface, generates two counter-rotating vortex rings, which travel radially outwards together and drive out the second crown through the free surface. The bottom vortex emerges from the separated boundary layer at the solid wall, while the top one detaches from the underside of the viscous drop. We map out the narrow parameter regime, where this ephemeral structure emerges, in terms of viscosity ratio, impact velocity and film thickness.
The critical points of vorticity in a two-dimensional viscous flow are essential for identifying coherent structures in the vorticity field. Their bifurcations as time progresses can be associated with the creation, destruction or merging of vortices, and we analyse these processes using the equation of motion for these points. The equation decomposes the velocity of a critical point into advection with the fluid and a drift proportional to viscosity. Conditions for the drift to be small or vanish are derived, and the analysis is extended to cover bifurcations. We analyse the dynamics of vorticity extrema in numerical simulations of merging of two identical vortices at Reynolds numbers ranging from 5 to 1500 in the light of the theory. We show that different phases of the merging process can be identified on the basis of the balance between advection and drift of the critical points, and identify two types of merging, one for low and one for high values of the Reynolds number. In addition to local maxima of positive vorticity and minima of negative vorticity, which can be considered centres of vortices, minima of positive vorticity and maxima of negative vorticity can also exist. We find that such anti-vortices occur in the merging process at high Reynolds numbers, and discuss their dynamics.
Depression is prevalent among patients with congestive heart failure (CHF) and is associated with increased mortality and healthcare use. However, most research on this association has focused on high-income countries, leaving a gap in knowledge regarding the relationship between depression and CHF in low-to-middle-income countries.
Aims
To identify changes in depressive symptoms and potential risk factors for poor outcomes among CHF patients.
Methods
Longitudinal data from 783 patients with CHF from public hospitals in Karachi, Pakistan, were analysed. Depressive symptom severity was assessed using the Beck Depression Inventory. Baseline and 6-month follow-up Beck Depression Inventory scores were clustered using Gaussian mixture modelling to identify separate depressive symptom subgroups and extract trajectory labels. Further, a random forest algorithm was used to determine baseline demographic, clinical and behavioural predictors for each trajectory.
Results
Four separate patterns of depressive symptom changes were identified: ‘good prognosis’, ‘remitting course’, ‘clinical worsening’ and ‘persistent course’. Key factors related to these classifications included behavioural and functional factors such as quality of life and disability, as well as the clinical severity of CHF. Specifically, poorer quality of life and New York Heart Association (NYHA) class 3 symptoms were linked to persistent depressive symptoms, whereas patients with less disability and without NYHA class 3 symptoms were more likely to exhibit a good prognosis.
Conclusions
By examining the progression of depressive symptoms, clinicians can better understand the factors influencing symptom development in patients with CHF and identify those who may require closer monitoring and appropriate follow-up care.
Fossil-Lagerstätten, or Lagerstätten, have played a critical role in our understanding of the diversity, abundance, evolution, and systematics of marine arthropods. The tendency toward preservation of Phanerozoic marine arthropods as fossils generally increases as a factor of biomineralization. Concentration deposits (Konzentrat-Lagerstätten) tend to have an abundance of biomineralized arthropod taxa, whereas conservation deposits (Konservat-Lagerstätten) tend to produce a higher biodiversity that includes biomineralizing and non-biomineralizing taxa. Some Lagerstätten incorporate aspects of both concentration and conservation deposits, indicating that these concepts are idealizations, or preservational end members. For arthropod occurrences, it is useful to consider another dimension of Lagerstätten: their taphonomic associations. This leads to a more nuanced understanding of arthropod fossilization history. Four taphonomic associations account for a substantial number of marine arthropod occurrences: (1) concretions, (2) clusters, (3) event beds, and (4) microbially sealed sediments. Each of these occurrences can blur the distinctions between, or the means of recognizing, the idealized genetic categories of concentration deposits and conservation deposits.
Despite the high prevalence of social and performance anxiety, current treatments do not meet the full needs of patients. Development of novel anxiolytics with rapid onset of action for on-demand treatment of social and performance anxiety is an active area of clinical research.
Aims
To examine the anxiolytic effect of VQW-765, an α7-nAChR agonist, in subjects with performance anxiety.
Method
We conducted a randomised, double-blind, placebo-controlled trial of 230 adults with a history of public speaking anxiety. Participants were randomly assigned to receive a single oral dose of 10 mg VQW-765 (n = 116) or placebo (n = 114), followed by a Trier Social Stress Test (TSST). Anxiety levels were assessed by the Subjective Units of Distress Scale (SUDS). Heart rate was monitored during the TSST. Plasma concentration of VQW-765 was measured after the TSST.
Results
Subjects receiving VQW-765 showed a trend of improvement in intensity of anxiety, as measured by the SUDS, during the performance phase of a TSST compared with placebo (P = 0.1443). Females showed a larger magnitude and significant response to VQW-765 (P = 0.034). The pharmacokinetic/pharmacodynamic analysis observed an inverted U-shaped exposure–response relationship. Subjects in the middle 50% quantiles of VQW-765 plasma concentration showed significant improvement in the SUDS rating compared with placebo (P = 0.033); however, subgroup analysis revealed this was true only for females (P = 0.005). VQW-765 was safe and well tolerated.
Conclusions
This is the first study showing anxiolytic effect of an α7-nAChR agonist in humans. VQW-765 is a promising candidate to be developed for on-demand treatment of social anxiety disorder.
Governments in both England and Korea prioritise a comparable set of childcare policies and strategies to promote young children’s development and wellbeing and maternal labour market participation. This paper compares the two marketised childcare systems and policies and their impact on family outcomes in the context of public policy aims to increase maternal employment. Despite Korean financial support for its childcare system being proportionally much greater than England’s, maternal employment rates in England far outstrip those in Korea. As our conceptual approach, we adopt Kagan’s (Kagan et al.; Kagan with Landsberg) application of systems theory to childcare systems. Important aspects of these two marketised systems and their infrastructure appear to be operating inefficiently, impeding equitable access to high-quality, sustainable provision. This evidence fails to explain, though, lower maternal employment levels in Korea, where a lack of active labour market policies coupled with socio-cultural factors form additional barriers. Both countries may be close to tipping points in childcare policy development. Extending childcare support beyond working families and curbing market operations may need considering in England, while in Korea expanding high-quality universal childcare support through public and not-for-profit providers and family-friendly employment policies requires addressing.
Mood and anxiety disorders co-occur and share symptoms, treatments and genetic risk, but it is unclear whether combining them into a single phenotype would better capture genetic variation. The contribution of common genetic variation to these disorders has been investigated using a range of measures; however, the differences in their ability to capture variation remain unclear, while the impact of rare variation is mostly unexplored.
Aims
We aimed to explore the contributions of common genetic variation and copy number variations associated with risk of psychiatric morbidity (P-CNVs) to different measures of internalising disorders.
Method
We investigated eight definitions of mood and anxiety disorder, and a combined internalising disorder, derived from self-report questionnaires, diagnostic assessments and electronic healthcare records (EHRs). Association of these definitions with polygenic risk scores (PRSs) of major depressive disorder and anxiety disorder, as well as presence of a P-CNV, was assessed.
Results
The effect sizes of both PRSs and P-CNVs were similar for mood and anxiety disorder. Compared to mood and anxiety disorder, internalising disorder resulted in higher prediction accuracy for PRSs, and increased significance of associations with P-CNVs for most definitions. Comparison across the eight definitions showed that PRSs had higher prediction accuracy and effect sizes for stricter definitions, whereas P-CNVs were more strongly associated with EHR- and self-report-based definitions.
Conclusions
Future studies may benefit from using a combined internalising disorder phenotype, and may need to consider that different phenotype definitions may be more informative depending on whether common or rare variation is studied.
This article explores a feminist approach to energy justice. In business and human rights to date, there has been little attention to the gendered dynamics in energy transition, mirroring the lack of attention to the rights of women and girls within broader energy and energy transition discourses. Without this attention, there is a risk that energy transition efforts maintain, increase, or create new gendered inequalities, rather than diminish them. With a focus on the distributional, recognitional and procedural dimensions of energy systems, the concept of energy justice holds much potential for the field of business and human rights. Taking women’s participation in energy transition policy-making in Sub-Saharan Africa as a concrete example, we argue that a feminist approach to energy justice could be one way of operationalizing a more gender-transformative energy transition.
The International Seabed Authority is under pressure from some states and companies to adopt the regulations that would allow deep seabed mining (DSM) to commence. While presented by its supporters as necessary to procure the minerals and metals needed for energy transition, DSM presents serious risks for the marine environments and human rights whose extent is still insufficiently understood. This article focuses on whether, should DSM be allowed in the short term, the current regulatory regime would suffice to ensure that the corporations leading this activity carry out effective assessment, prevention and mitigation of environmental impacts. In order to answer this question, it explores contractor obligations as they emerge from the current version of the ‘Mining Code’. In light of persisting scientific uncertainty and the high-risk profile of DSM activities, this article contends that the current version of the regulations does not devise sufficiently stringent due diligence obligations.
We analyse the small-scale characteristics, such as enstrophy, total strain and normality/non-normality, in the three-dimensional, separated flow around a NACA 0018 wing using direct numerical simulations. The angle of attack is $10^\circ$ and the Reynolds number (based on the chord length) is $Re_c=5000$. The role of non-normality is investigated by performing Schur decomposition of the velocity gradient tensor. We also apply the Schur decomposition to derive new expressions for the production of enstrophy and total strain arising from the mean flow inhomogeneity. We focus on two sections of the flow, across the recirculating zone and along the transitioning shear layer, and compare our results with homogeneous isotropic turbulence (HIT). Within the recirculating region, the non-normality index is approximately 0 (and close to the HIT value), indicating almost equal normal and non-normal contributions. However, in the separating layer non-normal effects strongly dominate, especially in the region of kinetic energy growth. Only in the decay region do the values of the non-normality index gradually approximate HIT values. The production of enstrophy due to vortex stretching is dominated by the mixed (interaction) term, where normal strain stretches non-normal vorticity. The same component also dominates the strain self-amplification term. The contributions of different QR regions to the production terms are also examined. Production due to mean strain rate is triggered upstream compared with production due to fluctuating strain fields.
The need to urgently shift away from fossil-based systems of energy for the sake of the planet and its people is clear. The green transition comes, however, with negative impacts on human rights and the environment, notably on the rights of Indigenous Peoples in the Global South, where most of the essential minerals and metals needed for the transition are found. In this piece, we discuss recent legal developments in the Netherlands from the perspective of the need for a just energy transition. Against the background of the recently adopted European Union (EU) Corporate Sustainability Due Diligence Directive (CSDDD), we analyze two draft Dutch due diligence laws and their potential in the context of a just energy transition. The focus is on the rights of Indigenous Peoples who are in an extremely vulnerable position in the transition process.
The United Kingdom was the first country to legalize the refusal to provide health care in the name of “conscientious objection”, allowing doctors to refuse to provide abortions based on personal or religious beliefs.
A historical review into the origins and motivation behind the “conscientious objection” clause in the 1967 Abortion Act found that Parliamentarians and the medical profession wanted to preserve doctors’ authority over patients, protect objecting doctors from liability, and appease religious anti-abortion beliefs.
These factors point to an unprincipled basis for the introduction of “conscientious objection” into healthcare, which ultimately came at the expense of patients’ rights and health. The “conscience clause” also represented a negation of basic ethical directives in medical practice including patient autonomy and physicians’ fiduciary duty to patients. The term “conscientious objection”— borrowed from the military but misapplied to healthcare — helped mask the practice as a moral “right” of doctors, even while it disregarded patients’ health and dignity.
Refusing to provide treatment on the basis of “conscience” is harmful and discriminatory, and should be phased out gradually using disincentives and other measures to encourage objectors to choose other fields.
The settling velocity of frozen hydrometeors in the atmospheric surface layer depends on their inertial and drag properties, and on the intensity of ambient turbulence. Thin, solid and perforated circular disks have been investigated through high-speed imaging, under laboratory conditions, to reproduce the settling of snow plates and dendrites in quiescent and turbulent flows. Different perforations made it possible to test the parameterisation of the fall speed in quiescent air, based on the geometric description of the solidity of the disk cross-sectional area. Interestingly, different falling styles, ranging from stable horizontal to fluttering and tumbling, were observed to depend significantly on the perforation geometry, which resulted in the stabilisation of the particle rotation and in a modulation of the drag coefficient. Ambient turbulence is observed to primarily induce cross-flow drag on the disks settling in the nonlinear regime, causing a reduction of the settling velocity in all cases investigated. Turbulence also manifests a secondary effect on the disk rotational dynamics, in particular when tumbling and stable falling styles co-exist, based on the phase space defined by the Reynolds number $Re$ and the inertia ratio $I^*$. The interaction between ambient turbulence, particle anisotropy and permeability and the likelihood of tumbling is inferred to be the main reason for the observed settling velocity variability of snow dendrites in nature.
Norway is, in many aspects, at the forefront of the global energy transition. Nevertheless, a human rights paradox in Norway’s energy transition plan is that while addressing climate-related human rights impacts, it might come at a high cost to the rights of the Indigenous Sámi People. Mining operations and renewable energy developments in the Sámi ancestral lands have already threatened reindeer husbandry, on which certain Sámi communities rely for a living, and which represents an integral component of their cultural identity. Resolving this paradox is crucial to achieving a just transition that leaves no one behind. Against this backdrop, the piece examines how the Norwegian Transparency Act—a mandatory human rights due diligence initiative—can address the impacts on Sámi rights caused by companies involved in renewable energy and extractive developments on Sámi lands.
The Hierarchical Taxonomy of Psychopathology (HiTOP) and Research Domain Criteria (RDoC) frameworks emphasize transdiagnostic and mechanistic aspects of psychopathology. We used a multi-omics approach to examine how HiTOP’s psychopathology spectra (externalizing [EXT], internalizing [INT], and shared EXT + INT) map onto RDoC’s units of analysis.
Methods
We conducted analyses across five RDoC units of analysis: genes, molecules, cells, circuits, and physiology. Using genome-wide association studies from the companion Part I article, we identified genes and tissue-specific expression patterns. We used drug repurposing analyses that integrate gene annotations to identify potential therapeutic targets and single-cell RNA sequencing data to implicate brain cell types. We then used magnetic resonance imaging data to examine brain regions and circuits associated with psychopathology. Finally, we tested causal relationships between each spectrum and physical health conditions.
Results
Using five gene identification methods, EXT was associated with 1,759 genes, INT with 454 genes, and EXT + INT with 1,138 genes. Drug repurposing analyses identified potential therapeutic targets, including those that affect dopamine and serotonin pathways. Expression of EXT genes was enriched in GABAergic, cortical, and hippocampal neurons, while INT genes were more narrowly linked to GABAergic neurons. EXT + INT liability was associated with reduced gray matter volume in the amygdala and subcallosal cortex. INT genetic liability showed stronger causal effects on physical health – including chronic pain and cardiovascular diseases – than EXT.
Conclusions
Our findings revealed shared and distinct pathways underlying psychopathology. Integrating genomic insights with the RDoC and HiTOP frameworks advanced our understanding of mechanisms that underlie EXT and INT psychopathology.