Van Fraassen does not argue that everyone should be a constructive empiricist. He claims only that constructive empiricism (CE) is a coherent post-positivist alternative to realism, notwithstanding the realist's charge that CE is arbitrary and irrational. He does argue, however, that the empiricist is obliged to limit belief as CE prescribes. Criticism of CE has been largely directed at van Fraassen's claim that CE is a coherent option. Far less attention has been directed at his claim that empiricists should be constructive empiricists. I consider his various attempts to support this claim, conclude that they are unsuccessful, and suggest that the empiricist who repudiates CE does not thereby abandon contemporary empiricism itself.

This paper develops an account of explanation in biology which does not involve appeal to laws of nature, at least as traditionally conceived. Explanatory generalizations in biology must satisfy a requirement that I call invariance, but need not satisfy most of the other standard criteria for lawfulness. Once this point is recognized, there is little motivation for regarding such generalizations as laws of nature. Some of the differences between invariance and the related notions of stability and resiliency, due respectively to Sandra Mitchell and Brian Skyrms, are explored.

As the seventeenth century progressed, there was a growing realization among those who reflected on the kind of knowledge the new sciences could afford (among them Kepler, Bacon, Descartes, Boyle, Huygens) that hypothesis would have to be conceded a much more significant place in natural philosophy than the earlier ideal of demonstration allowed. Then came the mechanics of Newton's Principia, which seemed to manage quite well without appealing to hypothesis (though much would depend on how exactly terms like “force” and “attraction” were construed). If the science of motion could dispense with causal hypothesis and the attendant uncertainty, why should this not serve as the goal of natural philosophy generally? The apparent absence of causal hypothesis from the highly successful new science of motion went far towards shaping, in different ways, the account of scientific knowledge given by many of the philosophers of the century following, notable among them Berkeley, Hume, Reid, and Kant. This “Newtonian” interlude in the history of the philosophy of science would today be accounted on the whole a byway. The Principia, despite its enormous achievement in shaping subsequent work in mechanics, was from the beginning too idiosyncratic from an epistemic standpoint to serve as model for the natural sciences generally.

Reductionism is a metaphysical thesis, a claim about explanations, and a research program. The metaphysical thesis reductionists advance (and antireductionists accept) is that all facts, including all biological facts, are fixed by the physical and chemical facts; there are no non-physical events, states, or processes, and so biological events, states and processes are “nothing but” physical ones. The research program can be framed as a methodological prescription which follows from the claim about explanations. Antireductionism does not dispute reductionism's metaphysical claim, but rejects the explanatory claim and so the methodological moral. To a first approximation what reductionists and anti-reductionists disagree about is whether explanations in functional biology can be or need to be explained or completed or perhaps replaced by explanations in terms of molecular biology. And this disagreement over the adequacy of explanations in functional biology drives a significant methodological disagreement with consequence for the research program of biology.

Advocates have sought to prove that underdetermination obtains because all theories have empirical equivalents. But algorithms for generating empirical equivalents simply exchange underdetermination for familiar philosophical chestnuts, while the few convincing examples of empirical equivalents will not support the desired sweeping conclusions. Nonetheless, underdetermination does not depend on empirical equivalents: our warrant for current theories is equally undermined by presently unconceived alternatives as well-confirmed merely by the existing evidence, so long as this transient predicament recurs for each theory and body of evidence we consider. The historical record supports the claim that this recurrent, transient underdetermination predicament is our own.

Classically, a gauge potential was merely a convenient device for generating a corresponding gauge field. Quantum-mechanically, a gauge potential lays claim to independent status as a further feature of the physical situation. But whether this is a local or a global feature is not made any clearer by the variety of mathematical structures used to represent it. I argue that in the theory of electromagnetism (or a non-Abelian generalization) that describes quantum particles subject to a classical interaction, the gauge potential is best understood as a feature of the physical situation whose global character is most naturally represented by the holonomies of closed curves in space-time.

The problem of scientific disregard is the problem of accounting for why some putative theories that appear to be well-supported by empirical evidence nevertheless play no role in the scientific enterprise. Laudan and Leplin suggest (and Hoefer and Rosenberg concur) that at least some of these putative theories fail to be genuine theoretical rivals because they lack some non-empirical property of theoreticity. This solution also supports their repudiation of the thesis of underdetermination. I argue that the attempt to provide criteria of theoreticity fails, that there is a Bayesian solution to the problem of scientific disregard that fares better, and that this successful solution supports a distinctively Bayesian version of the underdetermination thesis.

In “The Indeterministic Character of Evolutionary Theory: No ‘Hidden Variables Proof’ But No Room for Determinism Either,” Brandon and Carson (1996) argue that evolutionary theory is statistical because the processes it describes are fundamentally statistical. In “Is Indeterminism the Source of the Statistical Character of Evolutionary Theory?” Graves, Horan, and Rosenberg (1999) argue in reply that the processes of evolutionary biology are fundamentally deterministic and that the statistical character of evolutionary theory is explained by epistemological rather than ontological considerations. In this paper I focus on the topic of mutation. By focusing on some of the theory and research on this topic from early to late, I show how quantum indeterminism hooks up to point mutations (via tautomeric shifts, proton tunneling, and aqueous thermal motion). I conclude with a few thoughts on some of the wider implications of this topic.

In this paper, I examine the claim that any physical theory will have an extremely limited domain of application because 1) we have to use distinct theories to model different situations in the world and 2) no theory has enough textbook models to handle anything beyond a highly simplified situation. Against the first claim, I show that many examples used to bolster it are actually instances of application of the very same classical theory rather than disjoint theories. Thus, there is a hidden unity to the world of classical physics that is usually overlooked (by, for example, Nancy Cartwright who argues for the claims above). Against the second claim, I show that the practice of classical physics involves an enormous (infinite) number of models the use of which cannot be written off as merely ad hoc. Thus, although classical physics cannot, of course, model every situation in nature, it has a much larger domain than some would have us believe.

Our cognitive capabilities force us into a description of the world by levels. But theories on different levels result in descriptions that differ qualitatively. Therefore, the resulting incommensurability requires ontological bridges between such theories. These are obtained uniquely when the equations of the reduced theory are compared with a suitable limit of the equations of the reducing theory. Four case studies from theoretical physics and astronomy support this claim, two for theories of composites and two for non-composites (field theories). There results a coherent view of a single real world despite its ontological pluralism. The cumulativity of scientific knowledge is thus ensured and realism is supported.

This paper examines in detail two paths that lead to Structural Realism (SR), viz. a substantive philosophical position which asserts that only the structure of the world is knowable. The upward path is any attempt to begin with empiricist premises and reach a sustainable realist position. (It has been advocated by Russell, Weyl, and Maxwell among others.) The downward path is any attempt to start from realist premises and construct a weaker realist position. (It has been recently advocated by Worrall, French, and Ladyman.) This paper unravels and criticizes the metaphysical presuppositions of both paths to SR. It questions its very possibility as a substantive—and viable—realist thesis.

Following Nancy Cartwright and others, I suggest that most (if not all) theories incorporate, or depend on, one or more idealizing assumptions. I then argue that such theories ought to be regimented as counterfactuals, the antecedents of which are simplifying assumptions. If this account of the logical form of theories is granted, then a serious problem arises for Bayesians concerning the prior probabilities of theories that have counterfactual form. If no such probabilities can be assigned, then posterior probabilities will be undefined, as the latter are defined in terms of the former. I argue here that the most plausible attempts to address the problem of probabilities of conditionals fail to help Bayesians, and, hence, that Bayesians are faced with a new problem. In so far as these proposed solutions fail, I argue that Bayesians must give up Bayesianism or accept the counterintuitive view that no theories that incorporate any idealizations have ever really been confirmed to any extent whatsoever. Moreover, as it appears that the latter horn of this dilemma is highly implausible, we are left with the conclusion that Bayesianism should be rejected, at least as it stands.

Many areas of science develop by discovering mechanisms and role functions. Cummins' (1975) analysis of role functions—according to which an item's role function is a capacity of that item that appears in an analytic explanation of the capacity of some containing system—captures one important sense of “function” in the biological sciences and elsewhere. Here I synthesize Cummins' account with recent work on mechanisms and causal/mechanical explanation. The synthesis produces an analysis of specifically mechanistic role functions, one that uses the characteristic active, spatial, temporal, and hierarchical organization of mechanisms to add precision and content to Cummins' original suggestion. This synthesis also shows why the discovery of role functions is a scientific achievement. Discovering a role function (i) contributes to the interlevel integration of multilevel mechanisms, and (ii) provides a unique, contextual variety of causal/mechanical explanation.

The aim of this paper is to analyze a philosophical question (neutrality vs. theoryladenness of observation) taking into consideration the empirical results of Cognitive Psychology (theories of perception). This is an important debate because the objectivity of science is at stake. In the Philosophy of Science there are two main positions with regard to observation, those of C. Hempel and N. R. Hanson. In the Philosophy of Mind there are also two important contrasting positions, those of J. Fodor and Paul M. Churchland. I will analyze the consequences of recent theories of perception and vision developed within Cognitive Science for classical epistemological theses about observation.

Arthur Fine and André Kukla have argued that realism and instrumentalism are indifferent with respect to scientific practice. I argue that this claim is ambiguous. One interpretation is that for any practice, the fact that that practice yields predictively successful theories is evidentially indifferent between scientific realism and instrumentalism. On the second construal, the claim is that for any practice, adoption of that practice by a scientist is indifferent between their being a realist or instrumentalist. I argue that there are no good arguments for the indifference claim under the second interpretation, and good reasons to think that it is false.

Normic laws have the form “if A, then normally B.” They are omnipresent in everyday life and non-physical ‘life’ sciences such as biology, psychology, social sciences, and humanities. They differ significantly from ceteris-paribus laws in physics. While several authors have doubted that normic laws are genuine laws at all, others have argued that normic laws express a certain kind of prototypical normality which is independent of statistical majority. This paper presents a foundation for normic laws which is based on generalized evolution theory and explains their omnipresence, lawlikeness, and reliability. It is argued that the fact that normic laws are a product of evolution must establish a systematic connection between prototypical and statistical normality.