We review a combinatoric approach to the Hodge conjecture for Fermat varieties and announce new cases where the conjecture is true. We show the Hodge conjecture for Fermat fourfolds $ {X}_m^4 $ of degree m ≤ 100 coprime to 6, and also prove the conjecture for $ {X}_{21}^n $ and $ {X}_{27}^n $, for all n.

The experiment investigated the effects of dietary ascorbic acid and betaine stress responses, serum testosterone levels, and some sexual traits in male Japanese quails during the dry season. A total of 240 male Japanese quails (14 days old) were used and randomly assigned to four groups, each group has three replicates (n = 20). Birds in treatment groups were fed ascorbic acid (AA); betaine (BET); and AA + BET in their diets, whereas the control birds were fed only basal diet. Environmental conditions were predominantly outside thermoneutral zone for Japanese quails. Dietary AA ± BET increased (p < .05) serum catalase, reduced glutathione and testosterone, but lowered (p < .05) cortisol levels when compared with control group. Supplemental AA, BET, or AA + BET enhanced (p < .05) cloacal gland size and sexual traits. In conclusion, dietary AA and BET improved stress responses, serum testosterone levels, and some sexual traits in male Japanese quails during the dry season.

There is dearth information on the role of fisetin as an antistress agent in ameliorating heat stress in broiler chickens. Here, we experimentally compared probiotic, an antioxidant and antistress agent, with fisetin, an antioxidant agent with little or no report on its antistress effect. Sixty-day-old broiler chickens (Arbo Acre breed) were allotted into 4 groups of 15 birds each as follows; control, fisetin, probiotic, and fisetin + probiotic groups, respectively. All administrations were performed orally through gavage for the treatment groups. The environmental and cloacal temperature (CT) parameters were measured bi-hourly at Days 21, 28, and 35 from 7:00 to 7:00 hr, during the period of study. The environmental parameters exceeded the thermoneutral zone for broiler chickens. The probiotic-supplemented group had the least overall mean CT values all through the experimental period. Based on our findings, fisetin was not a potent antistress agent in mitigating heat stress in birds.

Philippine natural bentonite is characterized using X-ray diffractometer (XRD), scanning electron microscope (SEM), chemical analysis, thermogravimetric-differential scanning calorimetry (TG-DSC), and Fourier transform infrared (FTIR) analysis. The cation exchange capacity (CEC) was also measured. XRD shows that the mineral is composed primarily of mordenite, hectorite, and montmorillonite. SEM shows the flaky and porous structure of the bentonite powder. Chemical analyses show that SiO2 (47.90 wt%) and Al2O3 (14.02 wt%) are the major components of the clay. TG-DSC shows that the mineral contains 15.55% moisture. IR transmittance spectrum shows the common vibration bands present in the sample which include O–H stretching of inter-porous water, symmetric and asymmetric stretching of hydroxyl functional groups, asymmetrical stretching of internal tetrahedra (O–Si–O and O–Al–O), symmetrical stretching of external linkages, and so on. The measured CEC were found to be 91.37 and 43.01 meq/100 g according to the ammonium acetate method and barium acetate method, respectively.

Radars used to observe meteor trails in the mesosphere deliver information on winds and temperature. Use of these radars is becoming a standard method for determining mesospheric dynamics and temperatures worldwide due to relatively low costs and ease of deployment. However, recent studies have revealed that temperatures may be overestimated in conditions such as high geomagnetic activity. The effect is thought to be most prevalent at high latitude, although this is not yet proven. Here, we demonstrate how temperatures might be corrected for geomagnetic effects; the demonstration is for a particular geographic location (Svalbard, 78°N, 16°E) because it is local geomagnetic disturbances that affects local temperature measurements, therefore requiring co-located instruments. We see that summer temperatures require a correction (reduction) of a few Kelvin, but winter estimates are more accurate.

Herein, we report the synthesis and characterization of a novel class of polymer composites based on onion-like carbons (OLCs)-silicon diimide by a salt-free polycondensation reaction. The pyridine-catalyzed polymerization reaction was carried out in the presence of various contents (0.1, 0.5, 1, and 2 wt%) of carboxyl-functionalized OLCs in argon atmosphere to provide composites with well-dispersed and covalently incorporated 0D nanocarbons throughout the 3D matrix of silicon diimide polymer. A strong dependency of the optical properties (UV absorbance and the photoluminescence spectra) on the content of functionalized OLCs incorporated within the polymer matrix was observed. The novel polymer composites are suitable precursors for the design of advanced and multifunctional 0D-nanocarbon–containing Si3N4-based ceramic nanocomposites.

Lignin is a polyphenolic compound found in plant tissues, especially wood and bark. The lignin content determines the quality of wood biochar in agroecological uses, and is used in the production of synthetic resins and adhesives. Despite its importance in plant physiology and its agricultural and industrial utility, there exists a wide gap of knowledge of lignin contents of tropical hardwood trees of South Asia, except for a few species. We present here the first estimation of lignin content in wood and bark of 48 species from tropical deciduous forests of India. We show that some species are characterized by greater wood lignin (WL) compared with bark lignin (BL) content, contrary to the generalization held for hardwood trees, and suggest a plausible correspondence between the WL to BL ratio and timber quality.

Reliable hepatitis C prevalence estimates are crucial for a good follow-up of the indicators to eliminate hepatitis by 2030 as set by the World Health Organization. In Belgium, no recent national population-based hepatitis C virus (HCV) seroprevalence estimate is available. The current study estimated HCV prevalence as part of the first Belgian Health Examination Survey, which was organized in 2018 as a second stage of the sixth Belgian Health Interview Survey. This national population-based cross-sectional study resulted in a weighted national HCV seroprevalence of 0.02% (95% CI 0.00–0.07%). The results show a much lower HCV seroprevalence compared to previous studies.

Vitamin D is a steroid hormone well-known for its role in calcium homeostasis and bone health. Biological actions of vitamin D are mediated through the vitamin D receptor (VDR) present in various cells and tissues. Vitamin D has been implicated in multiple aspects of neuromuscular functions. This study aimed to investigate the role of VDR signaling during early stage of locomotor development utilizing a gene knockdown approach. Zebrafish larvae deficient in VDR showed severe motor impairment and no obvious response to touch. These results indicate that VDR signaling is indispensable for the correct neuromuscular development and touch-evoked escape swimming behavior in zebrafish.

The use of a Kaplan–Meier (K–M) survival time approach is generally considered appropriate to report antimalarial efficacy trials. However, when a treatment arm has 100% efficacy, confidence intervals may not be computed. Furthermore, methods that use probability rules to handle missing data for instance by multiple imputation, encounter perfect prediction problem when a treatment arm has full efficacy, in which case all imputed values are either treatment success or all imputed values are failures. The use of a survival K–M method addresses this imputation problem in estimating the efficacy estimates also referred to as cure rates. We discuss the statistical challenges and propose a potential way forward.

The proposed approach includes the use of K–M estimates as the main measure of efficacy. Confidence intervals could be computed using the binomial exact method. p-Values for comparison of difference in efficacy between treatments can be estimated using Fisher’s exact test. We emphasize that when efficacy rates are not 100% in both groups, the K–M approach remains the main strategy of analysis considering its statistical robustness in handling missing data and confidence intervals can be computed under such scenarios.

Evidence demonstrates increased vulnerability to thoughts and behaviors related to suicide (i.e., suicidal ideation) in students. This study examined the interaction between insomnia-symptoms and student-status (students vs. non-students) on reports of suicidal thoughts of behaviors. A total of 363 (N = 363) university students and 300 (N = 300) members of the general population provided complete data on measures of insomnia-symptoms and suicidal ideation. Students indicated greater reports of both total and lifetime ideation while also considering suicidal behavior within the past year. However, no differences were observed in reports of possible future attempt(s) and the disclosure of suicidal thoughts and behaviors to another person. Moreover, students presenting concurrent symptoms of insomnia reported significantly elevated levels of suicidal ideation relative to nonstudents. These outcomes highlight the possible role of insomnia symptoms in accentuating suicidal thoughts and behaviors in the student population.

Proton electrochemical gradient-driven multidrug efflux activity of representatives of the major facilitator superfamily (MFS) of secondary active transporters contributes to antimicrobial resistance of pathogenic bacteria. Integral to the mechanism of these transporters is a proposed competition between substrate and protons for the binding site of the protein. The current work investigated the competition between protons and antimicrobial substrate for binding to the Escherichia coli MFS multidrug/H+ antiporter MdtM by measuring the quench of intrinsic protein fluorescence upon titration of substrate tetraphenylphosphonium into a solution of purified MdtM over a range of pH values between pH 8.8 and 5.9. The results, which revealed that protons inhibit binding of substrate to MdtM in a competitive manner, are consistent with those reported in a study on the related MFS multidrug/H+ antiporter MdfA and provide further evidence that competition for binding between substrate and protons is a general feature of secondary multidrug efflux.

Compressible magnetohydrodynamic (MHD) turbulence is a common feature of astrophysical systems such as the solar atmosphere and interstellar medium. Such systems are rife with shock waves that can redistribute and dissipate energy. For an MHD system, three broad categories of shocks exist (slow, fast, and intermediate); however, the occurrence rates of each shock type are not known for turbulent systems. Here, we present a method for detecting and classifying the full range of MHD shocks applied to the Orszag–Tang vortex. Our results show that the system is dominated by fast and slow shocks, with far less-frequent intermediate shocks appearing most readily near magnetic reconnection sites. We present a potential mechanism that could lead to the formation of intermediate shocks in MHD systems, and study the coherency and abundances of shocks in compressible MHD turbulence.

Ethnoveterinary use of plants dates back to ancient times. This study aimed to validate purported efficacy of Sericocomopsis hildebrandtii and a concoction of Carissa edulis and Ximenia americana in treating Taenia solium cysticercosis in pigs. Twenty-four infected pigs were randomly allocated to T1, T2, and T0 groups, each with eight pigs. Each T1 pig was provided with 8 g of S. hildebrandtii root powder, whereas each T2 pig was given 8 g of the concoction. T0 was a control. The pigs were slaughtered 16 weeks post treatment and carcase dissections were performed to establish cyst numbers. T1 cyst numbers were significantly lower than those of T0 (p = .004) and T2 (p = .013). No difference was observed between T2 and T0. This study validated efficacy of S. hildebrandtii but not of X. americana and C. edulis. Further studies are necessary for validation and documentation of plants of ethnoveterinary importance.

This study investigated the effects of pretreatment with antioxidants, kaempferol, and zinc gluconate on serum biochemical changes and impairment in body weight gain following noise-exposure in Wistar rats. Thirty-five animals were evenly grouped into five cohorts: Groups II, III, IV, and V were exposed to noise stress, induced by exposing rats to 100 dB (4 hr/day) for 15 days, from days 33 to 48 after starting the drug treatments. Treatment with kaempferol and/or zinc mitigated noise-induced deficits in body weight gain, and levels of serum lipid and protein fractions. The combined treatment significantly (p < .05) decreased malondialdehyde concentration in kaempferol + zinc gluconate treated group, compared to the group administered deionized water + noise. This result demonstrates that biochemical dyshomeostasis and lipid peroxidation may be involved in the molecular mechanism underlying noise stress and the assortment of kaempferol and zinc gluconate produced an improved mitigating outcome in Wistar rats.

The anthelmintic dinitroaniline oryzalin interferes with the formation of microtubules and inhibits meiosis and mitosis in nematodes. Exposure to oryzalin resulted in deterioration in morphology of the oocytes and loss of synaptonemal complexes at meiotic prophase I. The nuclear matrix and envelope were poorly formed, and the central rachis was diminished. These results provide the basis for the loss of fecundity after treatment with the oryzalin resulting in control of parasitic nematodes.

In this study, we define the cardinal temperatures and thermal time for germination and emergence of pigeonpea genotypes. Seeds of six genotypes were subjected to constant temperatures ranging between 5 and 50°C in petri dishes with filter paper (germination) and with media (emergence) were placed in a thermal gradient plate. A nonlinear bent-stick model fitted to the rate of development to germination and emergence resulted in parameters predicting cardinal temperatures including base (Tb), optimum (To), maximum (Tm), and thermal time. Estimated Tb for 50% germination and emergence were 8.4 and 10.8°C, respectively, with no significant differences between genotypes. Optimum temperatures were 33.8 and 37.9°C for germination and emergence, respectively, with genotypes differing significantly. Thermal time for 50% germination and emergence varied significantly among genotypes. The results suggest that genotypic responses to the temperature are typical for their tropical origin and hence their suitability for cropping in summer dominant rainfall regions insubtropical Australia.