We challenge Ruchkin et al.'s claim in reducing short-term memory (STM) to the active part of long-term memory (LTM), by showing that their data cannot rule out the possibility that activation of posterior brain regions could also reflect the contribution of a verbal STM buffer.

We argue that models of reading should be based on anatomical reality, namely, the fact that both eyes are used in reading; and the observation that the human fovea is precisely vertically split, and projects each half of a fixated word to the contralateral hemisphere.

Standard models of cognition are built from abstract, amodal, arbitrary symbols, and the meanings of those symbols are given solely by their interrelations. The target article (Glenberg 1997t) argues that these models must be inadequate because meaning cannot arise from relations among abstract symbols. For cognitive representations to be meaningful they must, at the least, be grounded; but abstract symbols are difficult, if not impossible, to ground. As an alternative, the target article developed a framework in which representations are grounded in perception and action, and hence are embodied. Recent work (Glenberg & Robertson 1999; 2000; Glenberg & Kaschak 2002; Kaschak & Glenberg 2000) extends this framework to language.

A premise of Corballis's theory is that speech arose when vocalization co-opted existing gestural functions in the left ventral premotor cortex. Yet, visuomotor functions in this region remain largely unchanged between humans and macaques and have no discernible connection to gestural communication. This functional continuity suggests that language production is not the result of modifying existing motor functions in this region.

This commentary challenges the authors to use their computational modeling techniques to support one of their central claims: that schizophrenic deficits in bottom-up (Gestalt-type tasks) and top-down (cognitive control tasks) context processing tasks arise from the same dysfunction. Further clarification about the limits of cognitive coordination would also strengthen the hypothesis.

Data from magnetic resonance imaging (MRI), autopsy, endocranial measurements, and other techniques show that: (1) brain size correlates 0.40 with cognitive ability; (2) average brain size varies by race; and (3) average cognitive ability varies by race. These results are as replicable as one will find in the social and behavioral sciences. They pose serious problems for Rose's claim that reductionistic science is inadequate, inefficient, and/or unproductive.

The possibility that two forms of asymmetry underlie handedness is considered. Corballis has proposed that right-handedness developed when gesture encountered lateralized vocalization but may have been superimposed on a preexisting two-thirds dominance. Evidence is reviewed here which suggests that the baseline asymmetry is even more substantial than this, with possible implications for brain anatomy and genetic theories of handedness.

Context, connection, and coordination (CCC) describe well where the problems that apply to thought-disordered patients with schizophrenia lie. But they may be part of the experience of those with other symptom constellations. Switching is an important mechanism to allow context to be applied appropriately to changing circumstances. In some cases, NMDA-voltage modulations may be central, but gain and shift are also functions that monoaminergic systems express in CCC.

We tested whether the E-Z Reader model can be generalised to the French language. The simulation showed that the model can account for the frequency effect. The predictability effect is moreover accurate for word skipping, but not for fixation times. We think that this model is psychologically plausible for certain aspects of reading and we have used it to evaluate the performance of dyslexic readers.

Ruchkin et al. offer a compelling case for a model of short-term storage without a separate buffer. Here, I discuss some cognitive neuropsychological data that have been offered in support of and against their model. Additionally, I discuss briefly some new directions in cognitive neuropsychological research that bear on the role of attention in Ruchkin et al.'s model.

The E-Z Reader 7 model is powerful but incomplete. When programming the saccade to the next word, we take into account the familiarity of the letter sequences at the beginning of that word. This landing position effect is well established, but is neglected in the model. A possible locus for the effect is suggested within the E-Z Reader framework.

Consistent with Ruchkin and colleagues' proceduralist account, recent research on grouping and verbal-spatial binding in immediate memory shows continuity across short- and long-term retention, and activation of classes of information extending beyond those typically allowed in modular models. However, Ruchkin et al.'s account lacks well-specified mechanisms for the retention of serial order, binding, and the control of activation through attention.

Although context-processing deficits may be core features of schizophrenia, context remains a poorly defined concept. To test Phillips & Silverstein's model, we need to operationalize context more precisely. We offer several useful ways of framing context and discuss enhancing or facilitating schizophrenic patients' performance under different contextual situations. Furthermore, creativity may be a byproduct of cognitive uncoordination.

Anatomo-functional studies in humans point out that handedness and language-related functional laterality are not correlated – except during language production; and that the convergence of language and hand control is located in the precentral gyrus, whereas executive functions required by movement imitation and phonological and semantic processing converge onto Broca's area. Multiple domains are likely to be actors in language evolution.

This commentary points to the lack of sound data supporting Corballis's thesis that there is a general left-hemisphere dominance for nonverbal vocal production in mammals. I also point out that area F5 in the rhesus monkey, which Corballis considers as homologous to Broca's area, contains not only visual “mirror” neurons but also auditory “mirror” neurons. This weakens Corballis's thesis that language developed exclusively at the gestural level.

This commentary highlights methods for using scalp EEG to make inferences about contextual field interactions, which, in view of the target article, may be specially relevant to the study of schizophrenia. Although scalp EEG has limited spatial resolution, prior knowledge combined with experimental manipulations may be used to strengthen inferences about underlying brain processes. Both spatial and temporal context are discussed within the framework of nonlinear interactions. Finally, results from a visual contour integration EEG pilot study are summarized in view of a hypothesis that relates receptive field and contextual field processing to evoked and induced activity, respectively.

The view that posterior brain systems engaged in lower-order perceptual functions are activated during sustained retention is challenged by fMRI data, which show consistent retention-related activation of higher-order memory representations for a variety of working-memory materials. Sustained retention entails the dynamic link of these higher-order memories with schemata for goal-oriented action housed by the frontal lobes.

This commentary focuses on the two basic assumptions of the E-Z Reader model, discussing the possibility that adjacent words in reading may be processed in parallel rather than serially, and presenting evidence against a cognitive control of eye guidance in reading.

The issues the commentators have raised and which we address, include: the debate over how attention is allocated during reading; our distinction between early and late stages of lexical processing; our assumptions about saccadic programming; the determinants of skipping and refixations; and the role that higher-level linguistic processing may play in influencing eye movements during reading. In addition, we provide a discussion of model development and principles for evaluating and comparing models. Although we acknowledge that E-Z Reader is incomplete, we maintain that it provides a good framework for systematically trying to understand how the cognitive, perceptual, and motor systems influence the eyes during reading.

Phillips & Silverstein emphasize the gain-control properties of NMDA synapses in cognitive coordination. We endorse their view and suggest that NMDA synapses play a crucial role in biased attentional competition and (visual) working memory. Our simulations show that NMDA synapses can control the storage rate of visual objects. We discuss specific predictions of our model about cognitive effects of NMDA-antagonists and schizophrenia.