Field experiments were conducted in 1989 and 1990 to evaluate differential soybean cultivar tolerance to chlorimuron and imazaquin applied PPI, as influenced by soil moisture. Natural rainfall was supplemented with irrigation to achieve three moisture regimes: low (nonirrigated), optimum (5 cm wk–1), and excessive (15 cm wk–1). Imazaquin at 140 g ai ha–1 did not adversely affect height or yield of cultivars under any of the moisture regimes. Excessive moisture, regardless of herbicide treatment, reduced height and yield with many of the cultivars. Chlorimuron at 80 g ai ha–1 caused additional plant height reductions of 8 cm or more with ‘Asgrow 5403% ‘Asgrow 5979’, ‘Coker 686’, ‘Asgrow 6785’, ‘Hartz 6686’, and 'Sharkey’ in the excessive moisture regime, and yield was reduced 450 kg ha–1 or more with ‘Hutcheson’, ‘Terra-Vig 515’, Coker 686, Asgrow 6785, and Hartz 6686. Chlorimuron in the optimum moisture regime reduced the height of Coker 686 and ‘Deltapine 566’ 10 and 11 cm, respectively; however, no yield reductions were noted.