During summer 2020, observations of the mesosphere using a 53.5 MHz radar on Svalbard, at 78.2°N 15.1°E, revealed the well-known Polar Mesospheric Summer Echoes (PMSE). At the same time, a co-located meteor detection radar, operating at 31 MHz detected corresponding echoes very distinct from those associated with meteor trails. Comparing as many days as possible during 2020, incontestable evidence arose to demonstrate that the meteor detection radar was capable of observing PMSE, although not in the optimised fashion of the 53.5 MHz system. We present examples of results from both systems, supplementing the earlier findings of Swarnalingam et al. (2009), and simultaneously show very first results from this particular geographical location.

Denture-related stomatitis caused by Candida spp. affects elderly individuals using partial/total prosthesis, provoking several discomforts including burning sensation and altered taste. Herein, we have studied 52 denture-wearing individuals (>60 years-old), attended at the dentistry clinic of UNIVALE, aiming to isolate Candida spp. directly from the stomatitis lesions and to evaluate their potential to produce virulence attributes. A low prevalence of denture-related stomatitis was reported in these patients (4/52; 7.7%). Candida albicans was isolated in the 4 selected patients, with the ability to form biofilm over a polystyrene surface and to produce aspartic protease, esterase and hemolysin. However, neither phospholipase nor caseinase activities were detected. Planktonic-growing yeasts were susceptible to amphotericin B and caspofungin, while the susceptibility to azoles (fluconazol, itraconazole and voriconazole) varied depending on either the isolate or antifungal. Relevantly, biofilm-forming C. albicans cells exhibited resistance to all studied antifungals. So, new effective drugs against resistant C. albicans isolates causing denture-related stomatitis are urgently required.

Agricultural intensification within forage systems has reduced grassland floral diversity by promoting ryegrass (Lolium spp.), damaging soil functionality which underpins critical ecosystem services. Diverse forage mixtures may enhance environmental benefits of pastures by decreasing nutrient leaching, increasing soil carbon storage, and with legume inclusion, reduce nitrogen fertilizer input. This UK study reports on how species-rich forage mixtures affect soil carbon, phosphorus, and nitrogen at dry, medium and wet soil moisture sites, compared to ryegrass monoculture. Increasing forage mixture diversity (from 1 to 17 species) affected soil carbon at the dry site. No effect of forage mixture on soil phosphorus was found, while forage mixture and site did interact to affect soil nitrate/nitrite availability. Results suggest that forage mixtures could be used to improve soil function, but longer-term studies are needed to conclusively demonstrate environmental and production benefits of high-diversity forages.

Earlier reports revealed oxysterol metabolites of Opisthorchis spp. liver fluke origin conjugated with DNA bases, suggesting that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of the infection with these food-borne pathogens. Here, we employed liquid chromatography-mass spectrometry to investigate, compare and contrast spectrograms of soluble extracts from Fasciola hepatica adult worms from bile ducts of cattle with those from O. viverrini and O.felineus from experimentally infected hamsters. F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. These findings support the postulate that parasitic oxysterol-like metabolites could be related to carcinogenesis associated to infection and they point to a molecular basis for the differences among major groups of liver flukes concerning infection-induced malignancy.

Chordoma is a rare bone cancer for which there are no approved drugs. Surgery is the principle treatment but complete resection can be challenging due to the location of the tumours in the spine and therefore finding an effective drug treatment is a pressing unmet clinical need. A major recent study identified the transcription factor Brachyury as the primary vulnerability and drug target in chordoma. Previously, all-trans retinoic acid (ATRA) has been shown to negatively influence expression of the Brachyury gene, TBXT. Here we extend this finding and demonstrate that ATRA lowers Brachyury protein levels in chordoma cells and reduces proliferation of the chordoma cell line U-CH1 as well as causing loss of distinctive chordoma cell morphology. ATRA is available as a generic drug and is the first line treatment for acute promyelocytic leukaemia (APL). This study implies ATRA could have therapeutic value if repurposed for chordoma.

A practical bit condition monitoring system is a necessary component of autonomous drilling. Tricone bits are widely used in blasthole drilling in mining. Bits experience a variety of wear mechanisms during the operation and rolling element failure is the dominant catastrophic failure mode of tricone bits. Bit lifetime and performance significantly vary based on the working condition and the critical components of the bit i.e. rolling elements, are invisible to the direct condition monitoring systems. At McGill University, extensive research work is conducted to develop an indirect bit condition monitoring and failure prediction approach relying on the vibration signals and the technology is currently patent pending. This article presents real-world experimental evidence to show the unreliability of conservative bit changing strategy based on the bit operation life or drop in the rate of penetration (ROP) and ineffectiveness of direct wear monitoring techniques to cover the dominant failure mode.

A variety of machines are currently being used for mechanical excavation in mining and civil industries. A series of research works have been conducted at McGill University in the past decade to study the effects of microwave (MW) irradiation on rock mechanical properties. The idea is to enhance the excavation performance by improving the rate of penetration and decreasing the wear rate on the cutting tools. These two effects would eventually translate into economic benefits for mine operators. The effectiveness of MW on weakening rocks is proven, however the most efficient method to employ MW in mines is still under investigation. This article presents some experimental results on the effects of cooling- rate on rock strength. Brazilian Tensile Strength (BTS) of microwave treated samples were compared in natural air-cooled and water rapid-cooled conditions.

The influence of nutrient loading and other anthropogenic stressors is thought to be greater in low inflow, microtidal estuaries, where there is limited water exchange. This 11-month study compared spatial changes in macrofaunal communities adjacent to regions that varied in land cover in Oso Bay, Texas, an estuarine secondary bay with inflow dominated by hypersaline discharge, in addition to discharge from multiple municipal wastewater treatment plants. Macrofauna communities changed in composition with distance away from a wastewater treatment plant in Oso Bay, with the western region of the bay containing different communities than the head and the inlet of the bay. Ostracods were numerically dominant close to the wastewater discharge point. Macrobenthic community composition is most highly correlated with silicate concentrations in the water column. Silicate is negatively correlated with salinity and dissolved oxygen, and positively correlated with nutrients within the bay. Results are relevant for environmental management purposes by demonstrating that point-source discharges can still have ecological effects in hydrologically altered estuaries.

There are numerous associations between psychological characteristics and political values, but it is unclear whether messages tailored to these psychological characteristics can influence political decisions. Two studies (N = 398, N = 395) tested whether psychological-based argument tailoring could influence participants’ decision-making. We constructed arguments based on the 2016 Brexit referendum; Remain supporters were presented with four arguments supporting the Leave campaign, tailored to reflect the participant’s strongest (/weakest) moral foundation (Loyalty or Fairness) or personality trait (Conscientiousness or Openness). We tested whether individuals scoring high on a trait would find the tailored arguments more persuasive than individuals scoring low on the same trait. We found clear evidence for targeting, particularly for Loyalty, but either no evidence or weak evidence, in the case of Conscientiousness, for tailoring. Overall, the results suggest that targeting political messages could be effective, but provide either no, or weak evidence that tailoring these messages influences political decision-making.

Earlier work by the authors suggested that the formation of molten eutectic regions in Mg-Ca binary alloys caused a discrepancy in ignition temperature when different heating rates are used. This effect was observed for alloys where Ca content is greater than 1 wt%. In this work, the effect of two heating rates (25 °C/min and 45 °C/min) on the ignition resistance of Mg-3Ca is evaluated in terms of oxide growth using X-ray Photoelectron Spectroscopy. It is found that the molten eutectic regions develop a thin oxide scale of ~100 nm rich in Ca at either heating rate. The results prove that under the high heating rate, solid intermetallics are oxidized forming CaO nodules at the metal/oxide interface that eventually contribute to the formation of a thick and non-protective oxide scale in the liquid state.

The New pandemic is hitting all around the world in different manner. The infection rate, prevalence and severity is not patronized in many countries. Pakistan is now attaining the peak in its cases. Around 108,317 confirmed cases are present in Pakistan and 71,127 are currently active cases1. The recovery rate is 32%. The dangerous situation about the infection prevalence is that most of the people either are asymptomatic of having mild symptoms. An estimation release from Primary Health Department of Punjab claims that almost 670,000 cases are asymptomatic in only Lahore city 2. This correspondence is about an infected family of 5 people 3 males and 2 females in Lahore, Pakistan. Who were exposed with virus and one after one got the infection, the two males deceased but rest of family member are recovered.

Leishmania species are the causative agents for Leishmaniasis which is one of the neglected tropical diseases causing 70,000 deaths worldwide each year. Squalene synthase enzyme plays a vital role in sterol metabolism which is essential for Leishmania parasite viability. Therefore squalene synthase of Leishmania donovani is a therapeutic target to inhibit growth of parasite. The 3D model of Leishmania donovani Squalene Synthase (LdSQS) was generated by homology modeling and validated through PROCHECK, ERRAT, VERIFY3D and PROSA tools. Virtual screening of the protein was performed by AutoDock with reported inhibitor, E5700 and two natural alkaloids. Molecular interactions were explored to understand the nature of intermolecular bonds between active ligand and the protein binding site residues using UCSF Chimera and PLIP server. The reported inhibitor showed the best binding affinity (-9.75 kcal/mol) closely followed by Ancistrotanzanine B (-9.55 kcal/mol) and Holamine (-8.79 kcal/mol). Ancistrotanzanine B showed low binding energy and permissible ADMET properties. Based on the present study, homology model of LdSQS and Ancistrotanzanine B can be used to design inhibitors with antileishmanial activity.

Understanding the effects of predicted rising sea levels, combined with changes in precipitation and freshwater inflow on key estuarine ecosystem engineers such as the eastern oyster would provide critical information to inform restoration design and predictive models. Using oyster ladders with shell bags placed at three heights to capture a range of inundation levels, oyster growth of naturally recruited spat was monitored over the course of 6 months. Oyster numbers and shell heights were consistently highest in bottom and mid bags experiencing greater than 50% inundation (mid: 63 ± 7%; bottom: 95 ± 3%). Identifying thresholds for optimal oyster growth and survival to enhance restoration engineering would require finer scale evaluation of inundation levels.

There is growing interest in quantifying attitudes towards autistic people, however there is relatively little research on psychometric properties of the only existing measure and its ability to predict engagement with people with autism. To begin addressing these issues, we compared three scales measuring attitudes towards autistic people following the development of two new measures. Exploratory factor analysis, across two datasets, revealed that the factor-structure of an established 16-item scale is unclear. Further, its predictive validity of intended engagement with autistic people was comparable to our novel and psychometrically robust 1- and 4-item measures of attitudes towards autistic people. We therefore conclude that a 1- or 4-item scale is sufficient to measure general attitudes towards autistic people in future research. Equally, we propose that additional research is required to develop measures that are grounded in theoretical models of attitude formation and therefore distinguish between different components of attitudes.

The ongoing coronavirus disease 2019 (COVID-19) pandemic is of global concern and has recently emerged in the US. In this paper, we construct a stochastic variant of the SEIR model to estimate a quasi-worst-case scenario prediction of the COVID-19 outbreak in the US West and East Coast population regions by considering the different phases of response implemented by the US as well as transmission dynamics of COVID-19 in countries that were most affected. The model is then fitted to current data and implemented using Runge-Kutta methods. Our computation results predict that the number of new cases would peak around mid-April 2020 and begin to abate by July provided that appropriate COVID-19 measures are promptly implemented and followed, and that the number of cases of COVID-19 might be significantly mitigated by having greater numbers of functional testing kits available for screening. The model is also sensitive to assigned parameter values and reflects the importance of healthcare preparedness during pandemics.

Given extensive research underscoring the deleterious effects of bullying on youth adjustment, anti-bullying policies and programming are critical public health priorities. However, strategies that increase public support for anti-bullying causes are not well understood. This experiment assessed the influence of “bullying messaging” on support for anti-bullying policies. Specifically, I investigated whether learning about the health consequences of bullying, as opposed to its prevalence or educational impact, increased individuals’ support of anti-bullying policies. Participants (n = 329) were randomly assigned to one of four conditions where they read a brief summary about bullying research; conditions varied by whether the research documented the: a) prevalence of bullying b) mental health consequences of bullying c) physical health consequences of bullying or d) academic consequences of bullying. Results indicated that participants endorsed high levels of support for anti-bullying policies, regardless of experimental condition, and that policies aimed at increasing K-12 mental health resources were most supported.

Cyclopentadithiophene (CPDT), a Csp3-bridged bithiophene heteroaromatic unit, displays interesting properties when it is embedded in the repeating units of π-conjugated polymers, and they are applied in organic electronics devices. Common synthetic routes to CPDT-derived polymers rely on toxic methodologies whilst alternative non-toxic strategies such as the Suzuki-Miyaura reaction have been less studied. In this report we demonstrate that the use of a N-methyliminodiacetic acid (MIDA) boronate ester-derived CPDT monomer allows the efficient formation of poly(cyclopentadithiophene) homopolymer under Suzuki-Miyaura cross-coupling reaction conditions. Thus, the use of MIDA boronate esters might be extended to other organic units to design and construct a plethora of π-conjugated polymers.

Considering the Panigrahi and Chatterjee model (2017) for variable generalised Chaplygin gas, in this paper we found for this kind of exotic matter an analytic expression for the adiabatic compressibility βs. It was analyzed the behaviour of the adiabatic compressibility in the limit of high and low pressure. The derived equation for βs was used to deduce the value of the heat capacity at constant pressure Cp for variable generalised Chaplygin gas.