Pediatric psychiatric inpatients are among the most vulnerable individuals in society. While the use of seclusion and restraint is well chronicled in the field of research in this population, there is limited literature describing the effects, meaning, and attitudes of mandating the wear of clothing in hospital settings. This research explores the phenomenon of the practice of mandatory wear of hospital-issued clothing and its meaning to patients and the awareness and attitudes of this practice among staff caring for this population. This research aims to improve understanding of the experiences of patients regarding this practice at a large, urban hospital providing care for children using a mixed methods design. A qualitative, descriptive phenomenological analysis was conducted through individual interviews with adolescent patients (N = 5) on an inpatient psychiatric unit. Additionally, a cross-sectional self-reported questionnaire examined the awareness and attitudes toward this practice among unit staff (N = 41). The patients’ attitudes toward clothing restrictions was predominantly negative, noting a lack of self-expression, feeling like a mental health patient, desires to wear ones’ personal clothing, and feelings of shame and punishment. Among the staff there was a modest correlation between age, number of years practicing as a health professional, and years practicing in a pediatric setting with feelings of a need for a change in the clothing policy to allow patients to wear their own clothing on admission. Staff age and number of years working at the institution demonstrated a modest correlation between awareness of legal statutes regarding patients’ rights to their own clothing. This research found a readiness among staff to adopt a clothing policy that would permit patients to wear their own clothing on admission, which would improve the negative experiences described among the patients in the sample.

No Funding

The COVID-19 pandemic not only seriously threatens the health of contemporary college students, but also causes the spread of negative psychology to a certain extent, leading to the occurrence of depression. Positive psychology advocates to deal with psychological problems with a positive attitude. The study takes the COVID-19 as the background to explore the impact of positive psychology education on depressed college students.

116 college students suffering from depression were randomly selected from a university in China, and their negative psychological conditions were evaluated with Self-rating Depression Scale (SDS), and statistics were made. Then the positive psychology education intervention was carried out for these college students for 2 months. After the intervention, the negative psychological situation was evaluated again by SDS scale and compared with that before the intervention.

Table 1 showed the evaluation results of depression college students before and after positive psychological education intervention. It can be found that after the intervention of positive psychology education, students’ depression scores decreased significantly, and their negative psychology eased significantly, with a statistically significant difference (P < 0.05).Table 1.

Evaluation results of depression undergraduates before and after positive psychological education intervention

Under the COVID-19, the negative psychology of college students has seriously affected their normal life and study, and a considerable number of students are suffering from depression. The study intervened the negative psychology of college students through positive psychology education, and evaluated it through SDS scale. The results showed that the negative psychology of college students was significantly improved after the intervention, indicating that positive psychology education can effectively alleviate college students’ depression, and has certain clinical application value.

Workplace anxiety disorder has a negative impact on the mental health and work performance of employees in small and medium-sized enterprises. The research aims to explore the impact of establishing financial accounting management efficiency mechanisms on workplace anxiety disorder in small and medium-sized enterprises.

The study focused on small and medium-sized enterprise employees and divided them into an experimental group and a control group. The employees in the experimental group have established a financial accounting management efficiency mechanism, including standardized financial systems, clear accounting processes, and effective internal controls. The control group maintained traditional financial accounting management methods. The study used a questionnaire survey method to obtain data on employees’ workplace anxiety disorder scores, and used software Statistical Analysis Systems (SAS) for data processing and analysis.

The study found that the workplace anxiety disorder scores of the experimental group employees were significantly lower than those of the control group. The average anxiety score of the experimental group employees was 3.25, while that of the control group was 4.62. The t-test and analysis of variance were used to verify the statistically significant differences between the experimental group and the control group.

Results shown that small and medium-sized enterprises can significantly reduce workplace anxiety disorders by establishing financial accounting management efficiency mechanisms. Standardized financial systems, clear accounting processes, and effective internal controls can help alleviate employees’ anxiety.

Flibanserin, a serotonin antagonist currently indicated for treatment of female sexual dysfunction disorder, has not heretofore been described to worsen cerebellar function. Such a case is presented.

A 60-year-old woman, 8 months prior to presentation, had an acute onset of fainting and hitting her head into a wall without loss of consciousness. She could not stand up, had left-sided weakness, and vomiting, with garbled, slow speech and severe headache. Findings in the emergency room showed a left cerebellar parenchymal hemorrhage of 3.2 x 3.1 x 2 cm with the epicenter at the dentate nucleus, extending medially towards midline into the cerebellar vermis, with surrounding perilesional edema extending into the middle cerebellar peduncle. Also, 5.2 cm of the hemorrhage extended from the petrous of the tentorium to the cerebellar vermis. Moreover, a ventral left thalamic hemorrhage with subependymal clot at the foramen of Monroe extended into the dependent portion of lateral ventricles without midline shift. Post one month of physical therapy, speech, walking, and coordination improved but she continued to have delayed speech and trouble getting up, with a wide stance.

Neurologic Examination: Cranial Nerve (CN) Examination: CN XI: Sternocleidomastoid hypertrophy, horizontal titubation. Motor examination: Drift test: L pronator drift with L abductor digiti mini sign. Gait examination: heel walking, dystonic posture of L hand. Tandem gait: unstable, wide based. Cerebellar examination: Both (B) finger-to-nose dysmetria, Left > Right. Slow rapid alternating movements (RAM) L Upper Extremity (UE). Due to absent sexual desire she started 100 mg of flibanserin nightly. Maintaining this for 5 weeks, her coordination markedly worsened with poor balance and a need for a cane to ambulate. She would stumble, with a wider gait, and found climbing stairs challenging. Physical examination displayed worse cerebellar function: prominent horizontal titubation. Finger-to-nose—dysmetria L>R. Decreased RAM, L UE. Markedly positive Holmes Rebound phenomenon, Bilateral UE. Tandem gait: unstable. A week post stopping flibanserin, gait and cerebellar examination returned to baseline.

The temporal correlation between the use of flibanserin and transient worsening of cerebellar function strongly suggests that this is the causative agent. Since serotonin is essential in cerebellar function, including its action on the cerebellar cortex and deep cerebellar nuclei, it strongly suggests that its action as a serotonin antagonist is the mechanism whereby flibanserin is causing cerebellar symptoms. In those on flibanserin, investigation to detect the presence of cerebellar dysfunction is warranted. Assessment for the presence of cerebellar dysfunction in those who are on anti-serotonin drugs, such as cyproheptadine and methysergide, may be worthwhile.

No Funding

Learning anxiety has become a common problem among college students. Anxiety is also called psychological abnormality. The main symptoms of college students’ anxiety and depression include fear of negative evaluation in all aspects, excessive employment pressure, economic pressure, and inability to solve problems independently. Anxiety can cause symptoms such as insomnia and autism, and sometimes lead to adverse consequences or personal safety. Therefore, based on the healthy physical and mental development of college students, we can avoid learning anxiety through effective ideological and political management of humanism.

The study combined mental health and ideological and political courses, and selected 40 students from a university as research objects through random sampling. Before the activity, the ruminant thinking was evaluated, and after the evaluation, 40 students were instructed to participate in ruminant thinking under ideological and political management. The self-designed communication anxiety scale was used to evaluate the students. The scale included two dimensions: positive rumination and negative rumination. Positive rumination includes two indicators: positive coping and enjoyment of happiness, while negative rumination includes three indicators: negative attribution, inhibition of happiness and self-denial. The scale uses a four-level scoring method, which is inconsistent (4 points), uncertain (3 points), frequent (2 points), and completely consistent (1 point). The higher the total score, the higher the degree of positive or negative rumination.

The results of intervention control experiment under different ideological and political management are shown in Table 1.Table 1.

Students’ psychology before and after rumination intervention

It can be seen from the table that after the rumination intervention, the level of students’ communication anxiety has significantly decreased, and the average level of active rumination has significantly increased. Different students can get more positive feelings and have a better way of thinking in the ideological and political curriculum under the integration of ruminant intervention.

Research ruminant intervention to improve the ideological and political curriculum in colleges and universities, so as to alleviate college students’ depression and anxiety thinking. The research results show that the ideological and political courses after intervention have a certain effect on students’ communication anxiety, social anxiety relief, and effectively improve their psychological anxiety.

The research is supported by: General Project of Quality Project of Anhui Provincial Education Department: Research on Construction of Innovation and Entrepreneurship Courses in Universities under the Perspective of Curriculum Civics (No. 2020jyxm0357); Anhui Jianzhu University 2022 Party building and ideological and political education key topics, the new era of college students’ network ideological and political education implementation path research and practice, project number: 2022djszzd02.

With the rapid changes in the urban and rural economic structure, the issue of increasing farmers’ income and the income gap between urban and rural residents are continuously expanding. With the rapid changes in both, farmers’ anxiety is becoming increasingly severe. With the advancement of rural land transfer and agricultural modernization, there have been fundamental changes in farmers’ production patterns and lifestyles, which have had a profound impact on their mental health.

This article selects 156 farmers from a village and randomly divides them into an experimental group and a control group, each consisting of 78 farmers. The experimental group conducted psychological health recording tests under the exploration of innovative farmer income models; The control group was engaged in routine income activities without any changes. The experiment used Excel software and SPSS20.0 software to statistically analyze the results.

The results showed that there was a significant difference in anxiety symptoms between the two groups of farmers after innovating their income (P<0.05). The anxiety symptoms of the experimental group of farmers have significantly improved, and the proportion of people with reduced anxiety symptoms is as high as 90%.

To sum up, the emergence of farmers’ anxiety disorder is related to many factors, such as agricultural production, market contraction, and imperfect rural infrastructure. Innovating farmers’ income models can effectively alleviate the anxiety symptoms of farmers.

Depression is a mental disorder caused by many factors. Aromatherapy of traditional Chinese medicine delivers aromatic drugs to the human body to effectively prevent and treat diseases. In addition, appropriate sports can also improve the depressive symptoms of adolescents. Therefore, the study will combine traditional Chinese medicine aromatherapy with sports to intervene and treat adolescents to improve their symptoms.

In this study, 72 patients with insomnia symptoms of adolescent depression in a hospital were taken as the research object and randomly divided into groups A and B, with 36 patients in each group. Group A was given traditional methods, while group B was intervened with the combination of traditional Chinese medicine aromatherapy and sports. Pittsburgh Sleep Quality Index (PSQI) was used to quantify the score of insomnia symptoms in adolescents with depression. SPSS25.0 statistical software was used for the statistical analysis of relevant data. The results are shown in Table 1.Table 1.

PSQI score results of two groups of patients before and after the intervention

After the intervention, the total score of component B decreased from 12.10 ± 1.77 to 8.78 ± 1.67. To sum up, there is a big difference between group B and group A before and after the intervention, indicating that the combination of traditional Chinese medicine aromatherapy and sports has obvious advantages, which can effectively alleviate the symptoms of insomnia in young people.

Depression is easy to cause insomnia in young people, so the combination of traditional Chinese medicine aromatherapy and sports was used in the study. The results showed that the combined treatment was significant for the treatment of insomnia in adolescent depression patients.

Delusional hypergeusia has not heretofore been reported.

A 62-year-old right-handed woman described a plethora of complaints after exposure to a solvent aroma, including headaches, diffuse weakness, fatigue, hallucinated smells and tastes, burning mouth syndrome, and panic attacks. The apogee of her symptoms was that salty taste was 800% of normal, making food taste disgustingly salty. She was unable to tolerate potato chips, pizza, spaghetti sauce, Coca Cola, root beer, Sprite, 7 Up, and even bottled water. Sugar was also too sweet, 600% of normal. Foods which were unbearably sweet included cookies, sugar, and breakfast cereals. Sour and bitter were normal.

Abnormalities in Neurological Examination: Mental Status Examination: hyperverbal, loud, overly inclusive, irritable with pressured speech; disheveled, racing thoughts, and tangential. Motor Examination: Drift Test: right pronator drift with right abductor digiti mini sign. Gait Examination: heel walking with bilateral decreased arm swing. Reflexes: bilateral quadriceps femoris 3+, positive left (L) Hoffman’s reflex. Chemosensory Testing: Olfaction: Brief Smell Identification Test: 12 (normosmia). Retronasal Olfactory Testing: Retronasal Smell Index: 1 (Anosmia). Gustatory Testing: Propylthiouracil Disc Taste Test: 10 (normogeusia). Waterless Empirical Taste Test: sweet: 4, sour: 3, salty: 7, bitter: 5, brothy: 0, total: 30 (ageusia to umami, otherwise normogeusia). Neuropsychiatric Testing: Go-No-Go Test: 2/6 (abnormal).

Perhaps hypergeusia may not have been true hypergeusia but a misperception of retronasal smell associated hyperosmia with physiologic synesthesia manifested as taste. Peradventure, the perceived hypergeusia, is just one component of a generalized delusional paradigm, where many sensory perceptions are intensified. The perceived delusional hyperosmia may be intensification of the sensory misperception due to an underlying dysgeusia. This may represent a variant of the two-factor hypothesis of delusions whereby a distorted sensory perception is then misrepresented in a delusion. Dysfunction of the right hemisphere, which normally acts to censor the left, allows the delusion to manifest. While two different anatomical abnormalities (one left and one right hemisphere) have been postulated to be the foundation of such delusions, it is distinctly possible that a single lesion of the inferior parietal lobule may be sufficient for both sensory distortions to be produced as well as loss of inhibition of delusional interpretation of distorted sensation of the frontal lobe by the right parietal lobe, yclept the sensorialist hypothesis. In those who present with hypergeusia, search for delusional origin is warranted and in those who present with delusions, query as to perceived hypergeusia may be revealing.

No Funding

In recent years, the volunteer program of rural service for college students has been widely promoted and implemented, aiming to encourage the younger generation to give back to society and enhance understanding between urban and rural areas. However, in addition to traditional service goals, this study explores the impact of such projects on the social phobia of participants-college students, and how to alleviate their psychological barriers by enhancing their competence.

The study selected 120 students from a university as subjects and randomly divided them into an experimental group and a control group, each with 60 students. There was no difference between the two groups of subjects. The experimental group was provided with innovative service teaching and competency development. The control group did not take such training. Finally, the SCL-90 mental health test was used to evaluate the fear symptoms of college students before and after the intervention.

According to statistical analysis, with the improvement of competence, most participants reported that their fear symptoms had been eased. There was a significant difference in the symptoms of phobia between the two groups of students (P<0.05). The phobia of the experimental group was significantly reduced.

This indicates that innovative service teaching and competency development for college students with phobia can effectively alleviate their negative emotions and provide references for the medical field.

2022 Chongqing Social Science “Research on the Interpretation of the Spirit of the Sixth Plenary Session of the 19th CPC Central Committee” (2021YBCS12); 2022 Humanities and Social Science Research Project of Chongqing Education Commission (Ideological and Political Special Project) (22SKSZ080); 2022 Key Project of Higher Education Science Research of Chongqing Higher Education Association (CQGJ21A030).

Episodes of acute agitation can occur in individuals who suffer from schizophrenia or bipolar disorder and these can be a significant challenge for patients and for those who provide care to them. Sublingual dexmedetomidine is a selective alpha2-adrenergic receptor agonist that was recently approved by the US Food and Drug Administration for the treatment of agitation in adults with schizophrenia or bipolar disorder. The sublingual form of dexmedetomidine does not undergo first-pass hepatic metabolism, thus resulting in greater absorption than when ingested. In two Phase 3 studies of adults with schizophrenia or bipolar disorder, sublingual dexmedetomidine significantly reduced acute agitation at 2 hours, as measured by the five-item Positive and Negative Syndrome Scale-Excited Component (PEC). When initially appraising the potential utility of a new medication, number needed to treat (NNT) and needed to harm (NNH) can be helpful to assess the size of the treatment effect and, hence, clinical relevance.

Calculation of NNT and NNH through post hoc analysis of Phase 3 data.

Post hoc analysis of data were performed on data from two double-blind, randomized, placebo-controlled studies of sublingual dexmedetomidine in adults with schizophrenia or bipolar disorder experiencing acute agitation. Patients were randomized to a single dose of sublingual dexmedetomidine 180 μg, 120 μg, or placebo. The primary endpoint was mean change from baseline in the PEC total score. A therapeutic response was defined as a ≥40% reduction from baseline in PEC total score at 2 hours. NNT was calculated for PEC response rate for sublingual dexmedetomidine versus placebo. NNH was calculated using the incidence of adverse events for sublingual dexmedetomidine versus placebo. Likelihood to be helped or harmed (LHH) was calculated as the ratio of NNH to NNT.

NNT (95% CI) was 3 (2, 3) for 180 mcg and 3 (3, 4) for 120 ug in patients with schizophrenia and 3 (2, 3) for 180 mcg and 4 (3, 6) for 120 ug in patients with bipolar disorder. NNH was greater than 10 for all AEs except somnolence, where NNH was 7 (5, 10) for all doses pooled from both studies. LLH values were greater than 1 for efficacy versus applicable tolerability outcomes in all cases.

This post hoc analysis demonstrated favorable NNT and NNH values for sublingual dexmedetomidine. In all instances therapeutic response was encountered more frequently than any adverse event. These values compare favorably to similar analyses for other approved agents for the treatment of agitation associated with schizophrenia or bipolar disorder, including intramuscular and inhaled formulations.

BioXcel Therapeutics, Inc.

Employment anxiety is a kind of nervous and persistent negative emotion that college students have toward the future when they are about to graduate. It causes a series of cognitive, physiological, and behavioral changes, specifically manifested in the decline of sleep quality, anorexia, and pessimism. This psychological disease has a serious negative impact on the growth of college students. Psychological nursing is to conduct psychological counseling and intervention for patients, carry out mental health education, and help patients alleviate anxiety symptoms and emotions. Given the characteristics of employment anxiety in college students, on the one hand, innovative and entrepreneurial thinking training will provide employment ideas for patients; on the other hand, psychological nursing should be used to properly intervene the patients with employment anxiety, to promote the rehabilitation of the disease.

In the experiment, students suffering from employment anxiety were randomly selected from a university by simple random sampling and were equally divided into the experimental group (50 cases) and the control group (50 cases). The control group only carried out innovative and entrepreneurial thinking training, while the experimental group also carried out psychological nursing intervention in addition to innovative and entrepreneurial thinking training. One month after the experiment, the two groups of patients were evaluated and scored with the Employment Anxiety Scale and were judged whether they were cured.

One month after treatment, the two groups of patients were evaluated with the College Students’ Employment Anxiety Scale, and the results are shown in Table 1.Table 1.

Comparison of anxiety scale scores between the two groups after treatment

From Table 1, the average score of employment anxiety of the control group is 1.71 points lower than that of the experimental group. The cure rate of the control group was 87.52%, while that of the experimental group was only 66.13%. The cure rate of the experimental group was higher than that of the control group. The difference between the two groups was statistically significant, with P < 0.05.

Compared with the control group, the experimental group added psychological nursing intervention based on the routine treatment of college students’ employment anxiety. The results show that psychological nursing can effectively improve the employment anxiety of college students, and its therapeutic effect is significantly better than that of only carrying out innovative and entrepreneurial thinking training. Therefore, the use of innovative and entrepreneurial thinking training combined with psychological nursing intervention can improve the cure rate of college students’ employment anxiety.

Social marketing can enable enterprises to gain social recognition, and enhance customer trust and loyalty, while also improving financial performance and ultimately enhancing competitiveness. In recent years, concerns have become increasingly apparent that same-sex marketing strategies may lead to consumer hypochondria. In modern consumer culture, identity marketing strategies have become a common strategy. Given this, this study aims to identify the actual impact of same-sex marketing strategies on consumer hypochondria.

This study observed and selected 200 consumers with hypochondria from a certain hospital, who were randomly divided into an experimental group of 100 and a control group of 100. There was no significant difference between the two groups of patients obtained. Track and observe the behavior and purchase intention of two groups of consumers during consumption. The patients in the experimental group were accompanied by sales representatives with knowledge of same-sex marketing strategies to explain the connotation of the products during consumption; the control group did not make any changes. The experiment used SPSS24.0 to analyze the data.

Statistical analysis shows that the hypochondriac symptoms of the experimental group patients have significantly reduced, and there is a significant difference in hypochondriac symptoms between the two groups of patients (P<0.05).

Overall, there is a certain correlation between identity marketing methods and consumer hypochondria. Enterprises and marketers should be more cautious in designing and implementing their identity marketing strategies to ensure that they do not cause excessive concern and anxiety among consumers.

Schizophrenia affects individuals, families, and systems, with treatment primarily being antipsychotic medications. Long-acting injectable (LAI) antipsychotics are increasingly being used. This study sought to identify predictors of antipsychotic choice, in terms of formulation (LAI vs oral) and class (FGA vs SGA), and clinical outcomes.

123 patients who received LAI antipsychotics were diagnosis-matched to patients who received oral antipsychotics. Sociodemographic and clinical factors were extracted from the medical record, including indicators of illness severity. Groups were compared with Chi-Square and t-tests, and logistic regression models were used to identify independent predictors of antipsychotic choice.

Patients that received LAIs had longer admissions, more complex discharges, and greater illness severity; however, there were no differences in readmission rates. Independent predictors of LAIs included younger age, being single, and longer admission. Patients who received FGA LAIs were more likely to use substances and be undomiciled compared to SGA LAIs, with the only predictor being older age. Oral FGAs were more likely than oral SGAs to be prescribed to older and female patients, as well as those with co-occurring substance use, complex discharges, and longer admissions.

Illness severity and duration of illness appear to drive choice of LAI vs. oral antipsychotic medication and FGA vs. SGA. While LAIs were prescribed to patients with greater illness severity, readmission rates were equivalent to those receiving oral medication, supporting the use of LAI in patients with greater illness severity. Rationales for prescribing LAIs to younger patients and FGAs to older patients are discussed.

No Funding

How to enhance the psychological immersion of the audience is a major concern for the media at this stage. The psychological immersion of the audience not only affects the communication effect and influence of the media but also brings a more positive experience of reality to the audience. This project, therefore, analyses the psychological immersion of the audience based on the psychological experience process of shaping the media form of Vlog news.

In this research, 228 college students were selected as the subjects of the experimental research. The mean age was 21.12±1.67 years, with 146 male students and 82 female students. The general demographic characteristics of all subjects were counted before the experiment and there were no significant differences (P > 0.05). All subjects were divided into a control group and a research group in a completely randomized manner. The control group disseminated news through traditional means, while the research group used a Vlog news medium based on a psychological experience process to disseminate news. The immersion scale was assessed using the Igroup Presence Questionnaire (IPQ), which consists of 13 items, with questions 1-5 on the spatial presence (SP) dimension, questions 6-9 on the involvement (INV) dimension, and questions 10-13 on the reality (REAL) dimension. Each item was scored on a scale of 0 to 6, with 0 indicating total disagreement and 6 indicating total agreement.

On the IPQ scale, the mean score of SP dimension was 3.12 ± 0.34 in the control group and 4.87 ± 0.42 in the research group, with a significant difference between the two groups (P < 0.05); the mean score of INV dimension was 2.53 ± 0.36 in the control group and 4.71 ± 0.38 in the research group, with a significant difference (P < 0.05); the score of REAL dimensions was 2.98 ± 0.28 in the control group and 4.52 ± 0.41 in the research group, with a significant difference. and 4.52 ± 0.41 in the research group, with a significant difference (P < 0.05). See Table 1 for details.Table 1.

Comparison of IPQ scores between the two groups

Based on the psychological experience process, Vlog news media forms can increase the audience’s spatial immersion, psychological involvement, and authenticity experience. This increases the communication effect and influence of the media and has good research value.

Anxiety is a common phenomenon in English learning. In order to clearly demonstrate the impact of the integrated teaching of English education and educational psychology in universities on students’ anxiety disorder, this study conducted a questionnaire survey and structured interviews to investigate English anxiety and compare significant differences.

This study is based on the combination of English education and educational psychology. A questionnaire survey and structured interviews were conducted on 630 students from three different types of universities. The results of the “Foreign Language Anxiety Scale” and the “Foreign Language Anxiety Influencing Factors Scale” were tested and analyzed, and SPSS 23.0 statistical software was used for statistical analysis to compare the significant differences in the results.

The results show that the average anxiety level of English learning among college students is 3.00, which belongs to moderate anxiety. In terms of English anxiety level, there are significant differences in gender and professional factors (P<0.05), and there is no significant difference in language proficiency (P>0.05).

This study constructed a “Foreign Language Anxiety Scale” and a “Foreign Language Anxiety Influencing Factors Scale” with relatively ideal reliability and effectiveness. Combining the relevant theories of educational psychology and English learning, the data was analyzed using mathematical statistics, which is more in line with the English learning anxiety situation of Chinese students. Understanding students’ learning anxiety in English learning and teaching has important and practical significance.

The psychological problems of college students are the focus of social concern and hot discussions. Influenced by the epidemic, college students’ study, life and employment have been affected to a certain extent. Schools should strengthen mental health education to improve college students’ ability to resist pressure and help students improve their ability to adapt to society. Positive psychology can help students improve their mental health by guiding their mental activities and tapping their own strengths. In the process of using positive psychological knowledge to intervene with college students, self-help incentive training and personality cultivation can help students understand their own mental health problems. Therefore, in the psychological health education of colleges and universities, we can consider taking these two methods to carry out psychological intervention on college students, so as to improve the students’ ability to withstand pressure.

In the experiment, 360 college students who meet the requirements were randomly selected in colleges and universities through a questionnaire survey as the research objects of mental health problems. There are 187 boys and 173 girls, with an average age of (20 ± 2) years. The 360 college students were randomly divided into the intervention group and the control group, 180 in each. The intervention group used positive psychological thinking for psychological intervention, while the control group did not take any psychological intervention measures. The Perceived Stress Scale (PSS) was selected as the test scale of college students’ compressive capacity, and SPSS23.0 was used to analyze the score results.

The score of the PSS scale is shown in Table 1. It can be seen from the table that after the intervention group received the psychological intervention, their problem-solving and rationalization abilities were significantly improved (P < 0.05), and their withdrawal emotions were significantly reduced (P < 0.05).Table 1.

PSS score

The results show that after the intervention of positive psychology, the psychological pressure resistance of college students has been significantly improved, which helps to improve the level of mental health of college students, so as to better solve many psychological problems caused by the epidemic.

Tardive dyskinesia (TD) is a persistent and potentially disabling movement disorder associated with exposure to antipsychotics and other dopamine receptor blocking agents. Three valbenazine capsule strengths (40 mg, 60 mg, 80 mg) are approved for the once-daily treatment of TD. However, some patients with TD, especially in elderly populations, have trouble swallowing due to orolingual movements. This study was conducted to evaluate two different dissolution methods for valbenazine: whole intact capsules versus crushed capsule contents.

Samples were prepared using two commercial lots (Lot-A, Lot-B) for two doses (40 mg, 80 mg), with six replicate samples per lot and dose. The whole capsules were weighed, put into a sinker, and added to a dissolution bath containing 900 mL of 0.1N HCl at 37±0.5° Celsius. Testing on the crushed capsule contents commenced after opening the capsules, weighing and crushing the contents, and transferring the contents to the dissolution bath. Samples were collected (at 10, 15, 20, 30, 45, and 60 min) with a paddle speed of 50 rpm and analyzed using high performance liquid chromatography. Standards were prepared at nominal concentrations of 0.044 mg/mL (for 40 mg) and 0.089 mg/mL (for 80 mg).

Capsules were opened easily by manual manipulation, and contents were crushed easily between spoons. Very rapid (>85% in 15 min) and complete drug release was observed in all samples, independent of capsule strength (40 mg, 80 mg) or preparation (whole intact capsule or crushed capsule contents). For 40-mg capsules, average percent release at first and last collection timepoints were as follows (whole vs crushed): 10 min (98.4% vs 98.6% [A], 93.7% vs 97.6% [B]); 60 min (102.3% vs 100.5% [A], 100.9% vs 100.6% [B]). Results for 80-mg capsules were as follows: 10 min (98.2% vs 99.6% [A], 99.4% vs 97.9% [B]); 60 min (102.0% vs 101.6% [A], 103.2% vs 100.9% [B]).

Crushing the capsule contents did not impact the in vitro dissolution performance of valbenazine. Many patients with TD, particularly elderly patients, have difficulty swallowing and may benefit from alternative delivery methods for valbenazine, especially if other TD medications cannot be crushed. More research is needed to better understand if and how crushing the capsule contents of valbenazine affects their stability when mixed with food or delivered through a feeding tube.

Neurocrine Biosciences, Inc.

Chronic insomnia (CI) often co-occurs with depression and anxiety, and treatment may positively impact mood. This ongoing study collected real-world data on changes in insomnia, depression, and anxiety symptoms among adults with CI treated with a prescription digital therapeutic (PDT) delivering cognitive-behavioral therapy for insomnia (CBT-I; Somryst®, previously SHUTi).

This prospective, single-arm, pragmatic clinical study enrolled adults (≥18 years) in the US with CI and mobile device access. The PDT consists of six core modules completed over 6–9 weeks. In this interim analysis, participants completed the Insomnia Severity Index (ISI), 8-item Patient Health Questionnaire (PHQ-8), and Generalized Anxiety Disorder-7 scale (GAD-7) and other self-reported outcomes—at screening (baseline/prior to Core 1), end of treatment (Day 63), and 6-month follow-up (Day 243).

Mean ISI scores decreased (p<0.0001) from baseline (n=991) to post-treatment (n=777;18.8 vs 11.3) and to Day 243 (n=193; 18.8 vs 12.1). Mean GAD-7 scores improved from baseline to Day 63 (n=744; p<0.0001, Cohen’s d = 0.48) and to Day 243 (n=186; p<0.0001, d = 0.45). Similarly, PHQ-8 scores improved from baseline to Day 63 (n=747; p<0.001, d = 0.76) and to Day 243 (n=186; p<0.0001, d = 0.60). These patterns persisted across baseline anxiety and depressive severity levels among people with any baseline depressive or anxiety symptoms (all p<0.05 for depression, all p<0.0001 for anxiety), with large effect sizes observed for severe anxiety (d=1.43 Day 63, d=1.55 Day 243) and for moderate to severe depression (d range = 0.96-1.51).

In this study, treatment with digital CBT-I was associated with significant reductions in ISI, anxiety, and depression at posttreatment and at 6 months. The largest observed decreases in GAD-7 and PHQ-8 scores were among people with more severe baseline mood symptoms.

Pear Therapeutics (US), Inc.

Brand image design starts with sensory stimulation. Consumers experience the brand image, recognize the brand, and purchase goods through their senses, which is a comprehensive experience. Eliminating psychological barriers requires starting from an emotional perspective, as brand emotionalization often occurs from the beginning of user contact, and is conveyed through the senses to establish a “sensory” level emotional experience. This study utilizes cognitive psychology to analyze consumers’ bidirectional emotional barriers and establish a positive and emotional brand image.

This study uses SWOT analysis and semantic difference analysis methods. In terms of graphics, colors, and fonts proposed by a certain brand, eye tracking experiments will be conducted to collect images. 10 samples that meet the standards will be selected for redesign, and 4 of them will be evaluated through a questionnaire survey. SPSS23.0 statistical software will be used for statistical analysis to compare the significant differences in the results, and select the design scheme that best meets the emotional needs of consumers with bipolar disorder.

This brand image design based on cognitive psychology has analyzed the emotional characteristics and aesthetic experience of depressed consumers, and the sensory needs of patients with bipolar disorder are more moderate and smooth sensory elements.

This study utilizes a multi-sensory participation in brand image design and sensory interaction design mechanism, focusing on consumers themselves, allowing bipolar disorder groups to fully experience brand information and create a pleasant experience, and integrate into society.

General research projects of Pass College of Chongqing Technology and Business University in 2020 (No. KY202010).

The teaching support work of normal school students is a key step to improving students’ personal teaching abilities. It can help students understand the current situation of education in China and is a necessary way to enhance students’ sense of responsibility and mission in teaching. However, a large number of students will have significant mental symptoms such as depression and anxiety during teaching. Therefore, doing a good job in students’ mental health is not only conducive to teachers’ psychological construction, but also can promote students to develop a good outlook on education.

118 voluntary students in a university were taken as the research objects, and all the students were divided into an experimental group and a control group, with 59 students in each group. The intervention means based on the transformation of the management mode of psychotherapy combined with education were proposed. The students in the experimental group used the combined treatment means, while the students in the control group only used psychotherapy for intervention. The intervention lasted for 12 months, and the changes in anxiety and depression symptoms of students during the intervention were evaluated.

The differences in anxiety and depression scores of students before and after the treatment are shown in Table 1.Table 1.

Changes in scores of psychological depression and anxiety in two groups of students

The psychological condition of the students is the key to deciding whether their voluntary activities can be carried out normally. It can be seen from Table 1 that the depression and anxiety scores of students in the experimental group are significantly lower than those in the control group after the intervention. Therefore, it can be seen that the transformation of the management mode of psychotherapy combined with education can significantly reduce the current situation of psychological depression and anxiety of students in the support education, which is of great significance to the comprehensive development of students.

The research is supported by: The key commissioned project of Higher Education Teaching Reform of Heilongjiang Province in 2021: “The Research on the Effective Connecting Mode and the Implementation Path of Local Application-Oriented Universities’ Assistance in Poverty Alleviation and Rural Revitalization in Border Underdeveloped Areas” (the Fund Number: SJGZ20210047); The key project of Education Science Planning of Heilongjiang Province in 2021: The Research on the “Cross-border Integration” Talent Training Path of Specialty Groups of Tourism, Trade, Economy and Management of Special Application-oriented Undergraduate Demonstration Universities to Russia (the Fund Number: GJB1421625).