When artistic creators create art, they will suffer from mental anxiety due to the lack of spiritual level. Morita therapy often alleviates the clinical symptoms of anxiety disorder in patients by improving their “neuroticism” personality and urges them to recover their mental health. Therefore, Morita therapy was selected to intervene and treat the anxiety disorder of art creators, so as to improve their social adaptability and mental health.

The study took 78 art creators with anxiety disorders in a hospital since 2000 as subjects. Their anxiety disorders were divided into mental anxiety disorder (A) and somatic anxiety disorder (B). The total course of Morita therapy was 8 weeks, which was randomly divided into two groups, group C and group D. Group C was not intervened, while group D intervened with Morita therapy. Hamilton Anxiety (HAMA) was selected as the research evaluation scale. The experimental results are shown in Table 1.Table 1.

HAMA score results of two groups of patients before and after the intervention

The HAMA score after the intervention treatment was significantly lower than that before the intervention treatment, and the patients’ somatic anxiety and mental anxiety were reduced. Compared with group C, the mental anxiety of group D on both sides decreased more significantly, and decreased to 4.96 ± 1.87 in the 8th week after intervention, lower than 5.89 ± 1.57 in group C. To sum up, Morita therapy intervention has effectively alleviated the anxiety of art creators.

Artists who live more or less will have mental anxiety. The study used Morita therapy to intervene and treat their anxiety disorder. The results showed that Morita therapy effectively alleviated the mental anxiety of art creators.

The research is supported by: National social science fund project “Research on the Protection and Inheritance of Yao’s’ Ancient Legal Drum ‘Traditional Skills” (No. 21BMZ037).

Mixed depression is a common mental health problem that causes great distress to the patient’s life and social functioning. Due to historical and cultural tourism having communicative characteristics, it may have a positive effect on improving the symptoms of depression and is considered to affect improving mixed depression.

A randomized controlled trial design was used in this study, which included 100 patients with mixed depression. The intervention group received an 8-week historical and cultural tourism intervention, while the control group continued to receive conventional psychotherapy. The analysis tool uses SPSS23.0.

At the end of the study, patients in the intervention group showed significant improvement in depressive symptoms as measured by the Hamilton Depression Scale and Quality of Life questionnaire. Depression symptoms were reduced by 30 % in the intervention group compared to the control group. In addition, life quality in the intervention group also improved significantly, by 20% compared to the control group.

Historical and cultural tourism has a positive effect on improving the symptoms and life quality of patients with mixed depression. By providing new sensory and cognitive experiences, historical and cultural tourism can divert patients’ attention and emotions, and alleviate their depressive symptoms. The combination of historical and cultural tourism with drug and psychotherapy can become an effective and feasible treatment method, which provides a new choice and treatment means for patients with mixed depression.

Legal scholars have psychological problems because they have been in an “abnormal environment” for a long time. Music therapy is a psychological intervention method based on musicology, medicine and psychology. Therefore, the study used music therapy to intervene and treat the psychological diseases of legal scholars.

In the study, 84 patients with psychological diseases in a hospital in a western city were randomly divided into group A (41) and group B (43) by using SPSS21.0 statistical software. Group A was the control group without intervention; Group B was the music group, which was intervened by music therapy. In the experiment, Pittsburgh Sleep Quality Index (PSQI) was used to quantitatively evaluate the sleep quality of patients. The experimental results are shown in Table 1.Table 1.

Sleep quality of patients in the two groups before and after the intervention

Before the intervention, the sleep quality score of group B was significantly higher than that of group A, 2.62 ± 0.57 points; After the intervention, the indexes of group B were lower than those of group A, with a total score of 8.44 ± 2.01, much lower than 10.28 ± 2.14 in group A. The experimental results show that music therapy can significantly improve the psychological diseases of legal scholars.

Legal scholars often suffer from psychological diseases due to long-term “abnormal environment”. The study used music therapy as an adjunctive treatment, and the results showed that music therapy could effectively alleviate mental and psychological diseases.

Trace amine-associated receptors (TAARs) are a family of G-protein-coupled receptors (GPCRs) first identified in 2001. TAAR1 has emerged as a promising therapeutic target due to its ability to modulate monoaminergic and glutamatergic neurotransmission. Ulotaront is a trace amine-associated receptor 1 (TAAR1) agonist with serotonin 5-HT1A agonist activity that has received FDA Breakthrough Therapy Designation for the treatment of schizophrenia. Here we provide a brief review of the discovery of ulotaront and preclinical research suggesting efficacy in schizophrenia, leading to the first clinical trial of ulotaront resulting in FDA Breakthrough Therapy Designation.

Ulotaront was discovered through a target-agnostic approach optimized to identify drug candidates that demonstrate an antipsychotic-like profile in vivo but lack D2 and 5-HT2A receptor antagonism. Ulotaront was further characterized by in vitro pharmacology, electrophysiology, behavioral, and imaging studies.

Ulotaront demonstrated an antipsychotic-like profile in a high-throughput, phenotypic behavior screening platform, as well as efficacy in preclinical models of schizophrenia, including phencyclidine (PCP)-induced hyperactivity, prepulse inhibition of acoustic startle, and subchronic PCP-induced deficits in social interaction. Although not fully elucidated, ulotaront’s mechanism of action appears to be mediated by agonism at trace amine-associated 1 (TAAR1) and 5-HT1A receptors. This was further corroborated with whole cell patch clamp recordings, demonstrating inhibition of dorsal raphe nucleus (DRN) and ventral tegmental area (VTA) neuronal firing via 5-HT1A and TAAR1 receptors. Furthermore, ulotaront attenuated the ketamine-induced increase in striatal dopamine synthesis capacity, suggesting that it may modulate presynaptic dopamine dysfunction which is hypothesized to contribute to the pathophysiology of schizophrenia.

Preclinical studies have identified ulotaront as a TAAR1 agonist with antipsychotic-like activity. Ulotaront’s unique receptor profile led to its designation as a member of the new “-taront” class of TAAR1 agonists, distinct in pharmacology from the D2/5-HT2A class of antipsychotics. A companion poster will summarize the efficacy and safety of ulotaront based on initial clinical trials in schizophrenia.

Sunovion Pharmaceuticals, Inc., and Otsuka Pharmaceutical Development & Commercialization, Inc.

Mental retardation is a kind of mental disorder in which the intelligence of the patient is lower than that of children of the same age before maturity, which is specifically manifested as difficulties in social adaptation and sports ability defects. Music therapy establishes a good therapeutic relationship through music experience, without obvious toxic side effects. Therefore, the study used traditional Chinese musical instruments to intervene in patients with mental retardation and explore the therapeutic effect on fine motor development.

The 68 children with mental retardation who came to our hospital from February 2019 to June 2020 were selected and included in the study according to their compliance and the principle of parental voluntariness. Then, 68 children’s fine motor development quotient and original scores of fine motor test items were evaluated and recorded by Peabody Motor Development Scale. The patients were given music therapy with Chinese traditional instruments and music playing, three times a week. After 12 weeks of treatment, they were evaluated again with Peabody Motor Development Scale.

Table 1 shows the comparison of children’s fine motor scores and development quotient before and after music therapy. The results showed that the fine motor of the children improved significantly after treatment, with a statistically significant difference (P < 0.001).Table 1.

Comparison of fine motor score and development quotient of children before and after music therapy

Mental retardation is a kind of mental disorder that endangers the healthy growth of children. The study used music therapy of traditional Chinese musical instruments to treat patients with mental retardation. The results showed that the method effectively improved the fine motor function of children and had certain clinical application value.

In today’s society, social anxiety disorder has become a major psychological problem affecting People’s Daily life quality in recent years, especially among college students. Because of its collective and communicative characteristics, the collegiate instrumental ensemble is considered to be effective in alleviating social anxiety.

This study adopted a randomized controlled experiment design and selected 200 freshmen from a university as the research objects. According to the principle of voluntary, the students with social anxiety characteristics were randomly divided into two groups to be included in the study. The control group received routine psychological counseling, while the intervention group participated in the study and research of ethnic instrumental ensemble. The activity cycle was one semester, and ensemble training was conducted 3 times a week for 2 hours each time. In this study, two groups of students were measured before and after using the social anxiety scale. The analysis tool is SPSS23.0.

After one semester of study, it was found that the anxiety of students in the intervention group was significantly reduced, and the anxiety degree was more significantly decreased than that of the control group (P<0.01). The social anxiety level of the students in the intervention group remained relatively low during the three-month follow-up interview after the teaching.

The teaching of ethnic instrumental ensemble in colleges and universities can help alleviate the social anxiety of college students, improve their social ability and optimize the environment of campus mental health education.

The research results of the provincial-level teaching research project in Hubei Province’s higher education institutions (No. 2020379).

Solriamfetol is a wake-promoting agent (WPA) approved for the treatment of excessive daytime sleepiness associated with narcolepsy and obstructive sleep apnea. The wake-promoting mechanism of solriamfetol may result from dopamine and norepinephrine reuptake inhibition. Preclinical pharmacology studies were conducted to further elucidate the molecular targets activated by solriamfetol and compare them to that of known WPAs and traditional stimulants.

In vitro binding and functional studies were conducted in a panel of cell lines or membrane preparations expressing transmembrane receptors and monoamine transporters to measure the activity of solriamfetol, comparator WPAs, and traditional stimulants. Electrophysiology studies were conducted in slice preparations from mouse ventral tegmental area (VTA). Studies to measure locomotor activity and wake-promoting effects were conducted in mice.

In vitro functional studies showed agonist activity of solriamfetol at human, mouse, and rat TAAR1 receptors. hTAAR1 EC50 values (10–16 μM) were within the clinically observed therapeutic solriamfetol plasma concentration range and overlapped with the observed DAT/NET inhibitory potencies of solriamfetol in vitro. TAAR1 agonist activity was unique to solriamfetol; neither the WPA modafinil nor the DAT/NET inhibitor bupropion had TAAR1 agonist activity. Solriamfetol (1–10 μM) dose-dependently inhibited the firing frequency of dopaminergic VTA neurons in mouse brain slices, similar to known TAAR1 agonists; however, these effects were inhibited by a D2 antagonist, suggesting a DAT-mediated effect. Unlike traditional stimulants, solriamfetol did not increase locomotor activity in naive mice, but inhibited the increase in locomotor activity in DAT knockout mice.

Preclinical studies have identified agonist activity at the TAAR1 receptor and, possibly, lower potency agonist activity at 5-HT1A receptors as potential pharmacological targets for solriamfetol, in addition to its activity as a DAT/NET inhibitor. Given the current understanding of TAAR1 agonists as modulators of monoamine transmission with potential wake-promoting effects in multiple preclinical species, agonist activity at the hTAAR1 receptor may represent an additional pharmacological target underlying the wake-promoting effects for solriamfetol, in addition to its DNRI activity.

Axsome Therapeutics, Jazz Pharmaceuticals

Morita therapy, as a treatment for mental illness, aims to enable patients to accept their bad emotions so that they can effectively self-direct and regulate themselves, no longer be controlled by bad emotions, and ultimately eliminate their mental illness. Positive thinking refers to the individual’s purposeful, non-judgmental attention to the here and now. It emphasizes an attitude of acceptance to observe the inner experience, emotion, or behavior in the present moment. The study sought to investigate the effects of Morita therapy combined with positive thinking psychotherapy on the alleviation of mental anxiety disorders in design workers.

Currently, there have been relevant clinical studies showing that Morita therapy alone is not a good treatment for anxiety disorders. This experiment investigated the therapeutic effect of Morita therapy combined with positive psychotherapy. By means of questionnaires, 120 design workers with little difference in personal information but all suffering from mental anxiety disorders were selected as experimental subjects. The 120 subjects were randomly divided into three groups: subjects in group A were treated with Morita therapy combined with Shoujo psychotherapy, subjects in group B were treated with Morita therapy alone, and subjects in group C were treated with Shoujo psychotherapy alone. The whole course of treatment lasted for 3 months. The anxiety scores of the subjects before and after the experiment were recorded using the self-administered psychological anxiety scale.

In group A, the number of people suffering from severe anxiety, moderate anxiety, mild anxiety, and mental health before starting the experiment was 8, 30, 2, and 0, respectively, and after the mixed treatment, the number of people under each index became 0, 0, 8 and 32, respectively. In group B, the number of people suffering from severe anxiety, moderate anxiety, mild anxiety, and mental health before starting the experiment was 8, 29, 3, and 0, respectively, and after the Morita treatment, the number became 6, 16, 15 and 3, respectively. In Group C, the number of people suffering from severe anxiety, moderate anxiety, mild anxiety, and mental health before the experiment started was 6, 30, 4, and 0, respectively, and after the positive psychotherapy, the number changed to 3, 19, 13 and 5, respectively.Table 1.

Number of people with each type of anxiety level before and after the experiment under different treatment methods

This study demonstrates the effectiveness of Morita therapy combined with positive psychotherapy in relieving mental anxiety in design workers. The reason for this is that the operable psychological training program based on the principles of acceptance, trust, patience, and non-imposition of positive thinking training is more in line with the “let nature take its course” theory of Morita therapy, so the combination of the two therapies can play a complementary role. Therefore, the combination of the two therapies can play a complementary role.

The research is supported by: 2021 National Social Science Foundation Art Program. Social Studies of the Song Dynasty in the Prosperous Memory of the Chinese National Treasure “Picture of the River during the Qingming Festival” No. 21BG103.

Psychological trauma refers to the level of exposure during catastrophic events, including wars, sexual assault, earthquakes, etc. After experiencing, witnessing, or encountering these catastrophic events, we will experience varying degrees of emotional reactions such as fear, helplessness, or shock. This study will start with the post-traumatic stress disorder (PTSD) of college students and analyze the positive impact of ideological and political education concepts on students’ psychological resilience.

This study divided 120 PSTD college students who were affected by earthquake disasters into two groups, each consisting of 60 people. The experimental group received traditional psychological resilience positive emotion regulation therapy, while the control group received life cognitive therapy in ideological and political education based on traditional psychological resilience positive emotion regulation therapy. The study was measured using the Connor Davidson resilience scale (CD RISC).

The experimental results showed that the experimental group of college students experienced fewer PTSD symptoms and more positive emotions than the control group of college students.

In summary, the experimental group of college students showed a weakened tendency towards automatic processing of earthquake-related words (earthquake disaster words, earthquake rescue words), while experiencing more positive emotions and implicit biases; In the process of cognitive and emotional regulation, the experimental group of college students more effectively used cognitive reappraisal strategies to regulate their cognition and emotional processing of earthquake trauma.

Stage Results of the 2022 university-level Scientific Research Project of Hunan University of Information Technology (No. XXY022QN08).

Currently approved treatments for schizophrenia (antipsychotics) have demonstrated effectiveness for treating positive symptoms; however, these agents are largely ineffective in treating other domains. Negative symptoms, including avolition, alogia, blunted affect, and asociality, are difficult to treat, and often persist despite adequate control of positive symptoms. Additionally, some patients experience “predominant” (moderate-to-severe negative symptoms that have greater relative severity than co-occurring positive symptoms) or “prominent” (severity of negative symptoms [moderate-to-severe] without any reference to positive symptoms) negative symptoms. These symptoms are known to have great impact on patient social functioning and quality of life, and are associated with poorer clinical course and outcomes for patients. Here, we examined inpatient healthcare resource utilization in patients with schizophrenia experiencing predominantly negative symptoms (PNS).

De-identified data were extracted from electronic health records in the NeuroBlu Database across 25 US mental healthcare providers. Positive and negative symptom data were derived from free-text records using natural language processing. PNS was defined as the presence of three or more negative symptoms and three or fewer positive symptoms at first clinical contact following schizophrenia diagnosis. Groups were balanced for baseline demographic and clinical characteristics by minimizing the generalized Mahalanobis distance and compared using chi-square and t-tests. Treatment patterns were visualized using Sankey diagrams.

A total of 4444 patients with schizophrenia were identified and 8% were classified as PNS. A balanced cohort of 720 patients (50% PNS) was generated. Patients with PNS were more likely to be hospitalized in the 12 months following diagnosis (PNS: 76%, non-PNS: 60%, χ2: 22.5, p < 0.001) and were switched to a second-line antipsychotic after a shorter first-line treatment duration. The most frequently prescribed antipsychotics differed between groups (PNS: risperidone, aripiprazole, haloperidol; non-PNS: risperidone, olanzapine, other atypical).

This study demonstrates that negative symptoms in schizophrenia may be associated with worse illness course and higher healthcare resource utilization. There remains a need for new treatment options for patients with persistent, prominent, or predominant negative symptoms which specifically improve this historically hard-to-treat and assess symptom domain.

Sunovion Pharmaceuticals, Inc.

The clinical treatment method for social anxiety disorder is mainly psychological counseling combined with drug treatment, but it has been found in practice that drug treatment has obvious side effects. Psychological counseling intervention can be carried out for a long time and help prevent recurrence. At the same time, this study used interactive music therapy as a new treatment method to participate in psychological intervention for college students.

The study focused on 140 students with social anxiety disorder in universities and randomly divided them into two groups: an experimental group and a control group, with 70 students in each group. The control group received routine treatment, including health education, cognitive therapy, and behavioral therapy. Based on routine treatment, the experimental group received interactive music therapy to observe changes in quality of life and anxiety levels after treatment. Research on the Method of Evaluating Anxiety Level Using the Hamilton Anxiety Scale.

The comparison of anxiety levels between the experimental group and the control group before and after treatment is as follows: After treatment, 140 students showed improvement among chronic anxiety disorder, panic disorder, and total anxiety scores compared to before treatment; However, after interactive music therapy, the scores of the experimental group were significantly reduced compared to the control group.

In summary, interactive music therapy combined with psychological intervention methods can significantly improve the clinical symptoms, life quality, and social function of college students with social anxiety disorder.

At present, among college students, their psychological state has problems of varying degrees. Serious psychological problems will make students suffer from anxiety and depression and other mental diseases, which will damage their cognitive function, and then seriously affect their learning and life. Therefore, colleges and universities should pay close attention to students’ psychological state and improve the professional quality of teachers and students to help students improve their cognitive function of depression.

93 patients with depression from 3 colleges and universities were selected as the research objects to participate in the experiment of improving the cognitive function of depression by the combination of professional quality and psychosocial intervention in colleges and universities. In the experiment, 93 college students were divided into three groups, 31 in each group, which were the psychosocial intervention group, the intervention group for improving professional quality, and the combination intervention group. Self-Rating Depression Scale (SDS) and State Trait Anxiety Inventory (ATAI) were used to analyze the anxiety symptoms of college students before and after the experiment.

The SDS scores and ATAI scores of the three groups of patients before and after the experiment are shown in Table 1. Before the experiment, there was no significant difference in the scores of the three groups. After the experiment, the scores of each group decreased to varying degrees, and the effect of the combination intervention group was the most obvious.Table 1.

Comparison results of two groups of patients

In the research on the improvement of college students’ cognitive function of depression, the experiment successfully helped college students improve their mental status by combining the methods of improving college students’ professional quality with the methods of psychosocial intervention. Therefore, this method can significantly improve students’ cognitive function of depression.

Tardive dyskinesia (TD) is a persistent and often disabling hyperkinetic movement disorder associated with prolonged exposure to dopamine receptor blocking agents (e.g., antipsychotics, antiemetics). The use of anticholinergics for the treatment of movement disorders including TD is a common practice, despite a lack of supportive evidence and the potential to worsen TD. Moreover, there are now FDA-approved medications specifically indicated for TD. Two virtual meetings were held with movement disorder experts from neurology and psychiatry to better understand the real-world use of anticholinergics for TD.

In November 2020, a panel of eight experts was convened to gather insights on the challenges of differentiating TD from other drug-induced movement disorders (DIMDs) and to discuss appropriate treatments for TD and other DIMDs. A follow-up meeting was held in June 2021 to consolidate these insights. Key recommendations based on the panel discussions are presented.

The panel emphasized that while anticholinergics can help with managing some DIMDs, current evidence indicates that they are not effective in TD and may even worsen symptoms. Therefore, FDA-approved vesicular monoamine transporter 2 (VMAT2) inhibitors like valbenazine were recommended by the panel as first-line TD therapies. The panel noted that TD is often grouped under the term “extrapyramidal symptoms,” which leads to difficulty in differentiating TD from other DIMDs and the inappropriate treatment of TD with anticholinergics. The panel agreed that prophylaxis with anticholinergics is only appropriate in patients at high risk of acute dystonia. However, chronic anticholinergic use should be avoided whenever possible due to potentially serious adverse effects (e.g., cognitive difficulties) and anticholinergic burden, particularly in older patients. The potential for abuse, addiction, and diversion should also be considered when prescribing anticholinergics. Abrupt anticholinergic discontinuation can result in cholinergic rebound, which is characterized by sleep disturbances, gastrointestinal problems, urinary urgency, and manifestations of DIMDs. Thus, when used appropriately (e.g., for acute dystonia), anticholinergics should be prescribed at minimally effective doses and slowly tapered for successful discontinuation.

These findings align with the current TD treatment guidelines, including the lack of evidence for anticholinergic use and recommended first-line treatment with approved VMAT2 inhibitors. Conclusions from this panel highlight educational needs across HCPs on the phenomenology of DIMDs, the inappropriate use of anticholinergics for TD, TD risks and assessment, and treatment strategies for TD.

Neurocrine Biosciences, Inc.

The value of the unpaid labor performed by caregivers is estimated to be at least $306 billion annually, nearly double the combined costs of home health care ($43 billion) and nursing home care ($115 billion). However, studies show caregivers are at risk of developing high levels of physical, emotional, and mental strain, which can negatively impact their role, quality of life, and increase medical costs.

The project aims to determine if giving informal caregivers non-pharmacological interventions such as self-guided bibliotherapy, stress reduction interventions, and improving health literacy will reduce the role strain of informal adult caregivers and improve their quality of life.

This project employed a mix-method design focusing on the role strain and quality of life of relatives and friends assisting individuals with neurocognitive or mental health disorders. The subjects engaged in weekly self-guided activities for 8 weeks, and responded to survey questions regarding demographics, depression, anxiety, and stress levels. Personal health information (PHI) was not obtained. The subjects were required to answer qualifying questions. A $5 Amazon gift card was given to participants who completed the project.

Seven people enrolled in the project, but only four participated. All participants were female. Two were African Americans, one Caucasian, and one Hispanic. All four participants completed the pre-test, demographic surveys, and intervention. However, only two completed the post-test survey. One participant completed the pre-test and post-test on the same day at the end of the project.

Descriptive statistics were employed for the data analysis due to the small sample size. A non-parametric 2-independent sample test was used because of the small sample size. The test did not show any statistical significance between the variables in the pre-and post-test DASS-21 after the intervention. Subjects reported the project intervention was “helpful.” Another participant said she could not fully engage in the interventions because of family obligations. Still, she enjoyed the resources, such as the weekly NAMI family support group meetings given by the SI. The pre-test DASS-21 mean score for N=3 was 26 and standard deviation was 15.62.

The current COVID-19 has led to an increase in mental health issues. Because of the overwhelming increase in mental health cases, many individuals with mental health problems are being turned away. The decrease in the availability of mental health providers has led to an increased need for informal caregivers. However, studies show stress from caregiving can negatively affect the health of caregivers and result in loss of work productivity. However, specialized support for caregivers is frequently limited. Brown et al. (2016) said nonpharmacological self-help interventions such as bibliotherapy, stress-reduction techniques, and health literacy training could improve caregivers’ health. Therefore, lawmakers and healthcare professionals need to come up with interventions to help caregivers.

No Funding

Obsessive Compulsive Disorder (OCD) is a unique anxiety disorder characterized by repetitive or constantly invading thoughts, viewpoints, or images, as well as ritualized behaviors aimed at alleviating the anxiety caused by these thoughts and images. OCD may affect an individual’s life and social functions. This study started with the self-depletion and obsessive-compulsive disorder of personnel in the comprehensive service industry of foreign trade and analyzed the intervention effect of mindfulness meditation on patients.

This study selected 164 individuals from the OCD foreign trade comprehensive service industry as the research subjects. The subjects were divided into two groups, with 84 in the loss group receiving traditional intervention and 84 in the control group receiving mindfulness meditation intervention. The experiment adopts a dual-task paradigm. Task 1 uses the Chinese version of the E-crossing task as the self-control task, and Task 2 uses the Stroop task as the detection task. Subjective questionnaires and Stroop scores are used to examine whether E-crossing can effectively trigger self-loss.

Research has shown that completing a 6-minute Chinese version of an E-crossing task can effectively induce loss; Subjectively, the subjects in the loss group believe that the task is more difficult than the control group, and their scores in objective tests are significantly lower than those in the control group.

In summary, the compensation effect of mindfulness audio intervention on loss is better than that of relaxation training and other rest interventions at the same time. It is a universal, economical and convenient method for compensating loss and treating OCD among personnel in the foreign trade comprehensive service industry.

The COVID-19 has brought double pressure on the work and psychology of innovation and entrepreneurship personnel, which is prone to anxiety. Positive psychology can promote the all-round development of human body and mind. Therefore, under the epidemic environment, the research uses positive psychology to intervene and treat the psychological diseases of innovative and entrepreneurial personnel, and alleviate their psychological anxiety.

The study randomly selected 128 people who will carry out innovation and entrepreneurship from 2021 to 2022. The study used positive psychology to intervene 128 people, and judged their mental health status through their work enthusiasm and psychological resilience. In the experiment, P < 0.05 indicates that the difference is statistically significant, and t-test is conducted. After the experiment, SPSS21.0 was used for statistical analysis of the data. The experimental results are shown in Table 1.Table 1.

Changes in work enthusiasm and resilience of innovation and entrepreneurship personnel before and after intervention

Before the intervention, the self-assessment result of innovation and entrepreneurship personnel’s work enthusiasm was 5.27 ± 0.45 points, and the mutual evaluation result was 7.91 ± 0.42 points; After intervention, it was 7.91 ± 0.42 points and 9.10 ± 0.36 points. At the same time, after the intervention, the scores of three indicators in the scores of employees’ resilience level have increased. To sum up, positive psychology has effectively alleviated the psychological anxiety of innovation and entrepreneurship personnel. In addition, P < 0.001 indicates that the difference of the study has statistical significance.

The external environment of innovation and entrepreneurship in the context of the COVID-19 has gradually become worse, which has brought a lot of psychological pressure to innovation and entrepreneurship personnel, thus causing psychological diseases. The study used positive psychology to intervene, and the experimental results showed that positive psychological coping intervention for innovative entrepreneurs during the COVID-19 epidemic could effectively alleviate their psychological anxiety.

The research is supported by: the Key Construction Base of Philosophy and Social Sciences in Jiangsu Province, Research Center of Industrial Transformation and Innovation Development in Southern Jiangsu Province, No. 2018ZDJD-B008.

The constant mutation of the coronavirus during the COVID-19 caused enough anxiety and panic, as well as a decline in an otherwise healthy economy. As the economy continued to decline, more and more people had to face the risks and anxiety associated with unemployment. Dysthymia, also known as dissociative disorder, is a complex group of psycho-physical disorders in which, during the course of the illness, the patient manifests involuntary and intermittent loss of the ability to integrate some or all of the psycho-physical functions and is unable to achieve unity in the areas of perception, memory, emotion, behavior and self-awareness.

A series of research studies were conducted to investigate the manifestation and treatment of hysteria among the unemployed as a result of the economic recession in the wake of the COVID-19. Rational Emotive Behavior Therapy was used to treat the hysterical condition of the unemployed. A self-administered questionnaire was used to investigate the mental health of the unemployed in a region before and after the epidemic. 56 valid questionnaires were returned, excluding those that were not standardized. The 56 individuals were randomly divided into two equal groups and the subjects in the experimental group were treated with rational emotive behavior therapy, while the subjects in the control group were treated with general psychotherapy. A self-administered psychological assessment scale was used to score the mental health of the subjects before and after the treatment. The scale included indicators of perception, memory, emotion, behavior and self-awareness.

The degree of self-awareness retained by the two groups of subjects under the self-awareness index was selected for analysis before and after the experiment. The results in Table 1 show that the number of subjects in the experimental group with high, low and no self-awareness were 0, 9 and 19 respectively before the rational emotive behavior treatment; after the treatment, their numbers changed to 5, 21 and 2. On the contrary, the number of subjects in the control group before the general psychotherapy was 0, 7 and 21; after the treatment, their numbers changed to 1, 15 and 12.Table 1.

The degree of retention of self-awareness in the two groups of subjects before and after the experiment

Through questionnaires and a comparative experimental setup, it was demonstrated that the hysteria of unemployed people caused by the economic recession in the context of the COVID-19 manifested itself in the areas of perception, memory, emotion, behavior and self-awareness. The use of rational emotive behavioral therapy was able to treat their hysteria phenomenon and alleviate their psychological state of low or even no self-awareness.

Medication nonadherence is a public health concern and can impact clinical trial data quality. Traditional compliance collection (pill counts, diaries) can be unreliable in central nervous system trials. As such, strategies such as adherence technologies may play a key role in trial outcomes. AiCure, a computer vision-assisted dosing mobile application (app), collects dosing data and connects patients to sites for dosing support. Phone-based computer vision algorithms confirm dosing and transfer videos for artificial intelligence and human review. Boehringer Ingelheim is partnering with AiCure on pilot trials using AiCure adherence data to improve patient retention and clinical trial data quality. Here we report initial findings.

This pilot used data from two Phase II trials on the efficacy and safety of BI 409306 in people with schizophrenia (NCT03351244) or Attenuated Psychosis Syndrome (NCT03230097). The AiCure mobile app alerted participants to dosing protocols. The dose event was visually confirmed, providing sites a real-time view of adherence and allowing for targeted outreach and intervention. Adherence data from the first 2 weeks generated quantitative, machine-learning models to predict the individual adherence over the trial. Predictive modeling explored different monitoring periods (7-, 10-, and 14-day) and adherence cutoff points (0.8, 0.7, 0.6).

Initial AiCure assessment identified 43% of participants in NCT03351244 as ≤80% compliant (definition of compliance >80% compliant). Variance in adherence rates between electronic case report forms (eCRF; 78%) and AiCure (26%) data was also observed in the highly compliant/adherent group in NCT03230097. Using the first 2 weeks of adherence data (both studies combined), a participant’s adherence predicted their average adherence for the remainder of the trial. Observation of a participant’s adherence for the latest 4 weeks predicted the probability of premature dropout from the trial. There were further correlations of lower predicted adherence with actual disposition-based dropouts.

The early adherence predictive model (0.6 adherence cutoff) identified 22%, 20%, and 19% of patients for trial NCT03351244 (total n=235) as high-risk patients (low-adherence prediction) across 7-, 10-, and 14-day monitoring periods, respectively. Of those high-risk patients, 81%, 90%, and 96%, respectively, were truly nonadherent based on actual adherence data. The 14-day monitoring period model provided the lowest false omission rate, indicative of a better performing model.

AiCure data provided insights into patient behavior and adherence patterns which would not be available via CRF. Predictive models developed with AiCure adherence data can identify and predict future poor adherers. This creates opportunities to plan interventions and mitigation strategies to improve patient adherence during trials, thereby providing test drugs the best opportunity at proving efficacy.

Boehringer Ingelheim International GmbH (NCT03351244/1289-0049 and NCT03230097/1289-0032)

The integration of ideological and political courses into college student management has achieved positive results. This study explores the impact of applying motivation theory combined with positive psychology group therapy in English teaching on college students with schizophrenia.

The study selected schizophrenia students from a university as the research subjects and divided them into a control group and an experimental group. The control group received traditional college English teaching, while the experimental group applied motivation theory combined with positive psychology group therapy in college English teaching. The Schizophrenia Rating Scale was used for evaluation and statistical analysis was conducted using SPSS22.0.

After a 6-month experiment, the score on the schizophrenia rating scale in the control group changed from 72 to 69 points, while the score in the experimental group changed from 75 to 58 points. In the experimental group, the symptoms of students with schizophrenia were significantly relieved (P<0.05). The experimental results show that combining motivation theory with positive psychology group therapy in college English teaching has a significant influence on college students with schizophrenia.

The application of motivation theory combined with positive psychology group therapy in college English teaching can effectively affect the symptoms of college students with schizophrenia, providing a potential treatment method. This research result provides reference and inspiration for the field of college English teaching and mental illness treatment.

In recent years, the issue of employment anxiety disorder among science and engineering college students has become increasingly prominent. The study analyzed the relevant factors of employment anxiety disorder among science and engineering students through text mining methods.

The study selected students from a certain university of science and engineering as the research subjects and divided them into anxiety group and non-anxiety group. Social media data was used for text mining to identify factors related to employment anxiety disorder among science and engineering students. The statistical software SPSS23.0 is used to analyze data and evaluate the correlation of factors using methods such as t-tests or correlation coefficients.

By analyzing social media texts of science and engineering students, research has identified several factors related to employment anxiety. In the anxiety group, the score of employment pressure was significantly higher than that of the non-anxiety group (M=4.58 in the anxiety group, M=3.26 in the non-anxiety group, P<0.001), Score of career uncertainty (anxiety group M=3.92, non-anxiety group M=2.95, P<0.001), competitive pressure (anxiety group M=4.27, non-anxiety group M=3.18, P<0.001), and career development opportunities (anxiety group M=2.68, non-anxiety group M=3.52, P<0.001). The results showed significant high scores in the anxiety group.

The research provides valuable information for universities and related institutions to develop targeted coping measures and psychological support, thereby reducing the employment anxiety disorder of science and engineering students and promoting their career development.