Bipolar depression is increasingly affecting people’s quality of life. There are mainly medication and psychotherapy for treatment, but there also exist psychological and social environmental factors that affect the symptoms. This study will use a combination of Western medicine and medication to improve and innovate community work mechanisms, and provide group integrated psychotherapy for patients.

100 patients diagnosed with depression from a specific hospital underwent psychological evaluation, and were randomly divided into an experimental group and a control group, with 50 patients in each group. The experimental group received a combination of Western medicine and group integrated psychotherapy, complemented by community work mechanisms. The control group received only a combination of Western medicine and group cognitive behavior therapy. The experimental data was analyzed using SPSS23.0 statistical software, which included descriptive statistical analysis.

The results showed that the total scores of the Hamilton Depression Scale (HAMD) in the two groups were significantly lower than before treatment. After SPSS analysis, the difference in results was F=102.48, P=0.001, F=55.96, P<0.001, with statistical significance. After 4 and 8 weeks of treatment, the difference in results between the two groups of HAMD was t=3.49, P=0.001, t=2.51, P<0.19, with statistical significance.

This study found that group integrated psychotherapy combined with community work mechanisms is significantly superior to group cognitive behavior research, which can improve patients’ treatment enthusiasm and early differences. Group integrated psychotherapy combined with community work mechanisms can effectively enhance patients’ psychological resilience.

The research is supported by: Jiangsu Province University Philosophy and Social Science General Project (2021) “Study on the Governance Mechanism of Village Leaders in Rural Construction--Based on Suqian Practice” (No. 2021SJA2203).

As college teachers, counselors are mainly responsible for the political work of school students. Besides, college counselors also need to be responsible for students’ ideological and psychological education, and be their political leaders and psychological. At present, many colleges have introduced political education and mental health education, but there is relatively little research on the combination of the two. The training and assessment for college counselors are also only focused on political work at present. It is crucial to explore the path for college counselors to carry out political work and psychological counseling work under the dual role orientation.

A set of controlled experiments was set up to explore the development of counselors’ political work and counseling work under different educational and teaching modes. One hundred and forty-four counselors from a college in China were selected as the study subjects. The 144 counselors were randomly divided into three groups of equal number, which were recorded as group A, group B and group C. The counselors in group A were given political work training only, those in group B were given mental health education only, and those in group C were given a combination of political work training and mental health education. The training is taught over a period of five months, with counsellors tested on their political work and mental health scores at two-month intervals.Table 1.

Mean scores of subjects in different groups before and after the instruction

In the first month of training, the mean scores of subjects in groups A, B and C were 65.12, 62.35 and 64.19 before the instruction, and after the instruction, their scores changed to 65.78, 62.38 and 66.78. In the third month, the mean scores of subjects in the three groups were 65.22, 62.58 and 72.21 before the instruction, and 68.23, 65.21 and 78.45 after the instruction. In the fifth month, the mean scores of the three subjects were 68.95, 65.59 and 81.45 before the instruction, and after the instruction, their scores changed to 70.12, 68.71 and 85.18.

Political work training or mental health education alone is not as effective as combined teaching. To cultivate the dual roles of college counselors, both political work and psychological counseling should be combined.

The research is supported by: 2022 Chongqing Social Science “Research on the Interpretation of the Spirit of the Sixth Plenary Session of the 19th CPC Central Committee” Special Project “Research on Maintaining the Authority and Centralized Unified Leadership of the CPC Central Committee in the New Era” (No. 2021YBCS12); 2022 Humanities and Social Science Research Project of Chongqing Education Commission (Ideological and Political Special Project) “CPC Secretary General Xi Jinping’s An important Treatise on the Need to Improve the ‘Three Abilities’ on Politics” (No. 22SKSZ080); 2022 Humanities and Social Science Research Project of Chongqing Education Commission (Selective Funding Program for Outstanding University Counselors) “Research on the Path of University Counselors to Improve the ‘Three Abilities of Politics’” (No. fdyzy2022007); 2022 key Project of Higher Education Science Research of Chongqing Higher Education Association “Research on the Political Ability of University Counselors in the New Era” (No. CQGJ21A030).

reSET-O® is an FDA-authorized prescription digital therapeutic (PDT) for opioid use disorder (OUD) providing cognitive behavioral therapy as an adjunct to buprenorphine therapy. This analysis describes differences in inpatient hospitalization rates over a 2-year period between patients treated with the PDT and those who were not.

A real-world claims analysis using the HealthVerity Private Source 20 database compared inpatient hospitalization rates (including intensive care unit stays and rehospitalizations) in patients who filled a reSET-O prescription (“cases”) to patients not filling their prescription (“controls”). Index date was date of reSET-O initiation for cases, and prescription date for controls, from January 1, 2019 to June 30, 2020. Pre- and post-index incidence rates of HCRU were compared with the incidence rate ratio (IRR) using a repeated-measures negative binomial model, adjusted for age, sex, region, payer type, Charlson comorbidity index (CCI) score, and number of similar services in the 12 months pre-index with an offset for number of days in the 12-month post-index period. Adjusted differences in inpatient hospitalizations in cases vs. controls were evaluated at 3-month intervals beginning at 12 months pre-index through 12 months post-index, using a difference in differences (DID) approach.

In this analysis, 901 cases (median age 36 years, 62.4% female, 73.9% Medicaid recipients, 95% treated with buprenorphine in the post-index period) were compared with 978 controls (median age 38 years, 55.1% female, 65.4% Medicaid recipients, 95% treated with buprenorphine in the post-index period). Incidence rate ratios of inpatient stays trended lower in later pre-post comparison periods among cases (IRRs 0.80, 0.95, 0.87, and 0.75 at 3-, 6-, 9-, and 12 months pre-post, respectively), and trended higher in later pre-post periods in controls (IRRs 0.93, 0.83, 0.86, 0.88 at 3-, 6-, 9-, and 12-month intervals respectively). The DID for controls vs. cases during the 12-month post interval compared to the 12-month pre-index rates, represented a 44% lower incidence of inpatient hospitalizations vs. controls between the first and last quarters of observation.

This difference in difference analysis showed a lower 12-month pre-post incidence rate ratio of inpatient hospitalizations for patients using reSET-O vs. controls, and a 24-month change in quarterly inpatient hospitalizations in reSET-O patients that was almost half that of controls.

Pear Therapeutics (US), Inc.

This analysis examined the impact of a digital therapeutic for treating chronic insomnia (currently marketed as Somryst®, at the time called Sleep Healthy Using The internet [SHUTi]) on healthcare resource use (HCRU) by comparing patients treated with the digital cognitive behavioral therapy for insomnia (dCBTi) to patients not treated with dCBTi, but with insomnia medications.

A retrospective observational study using health claims data was conducted in two cohorts across the United States: patients who registered for dCBTi (cases) between June 1, 2016 and October 31, 2018 (index date) vs. patients who did not register for dCBTi but initiated a second prescription for an insomnia medication in the same time period (controls). Observation period was 16–24 months. No other inclusion/exclusion criteria were used. Control patients were matched using a nearest neighbor within-caliper matching without replacement approach. Incidence rates for HCRU encounter type were calculated using a negative binomial model for both cohorts. Costs were estimated by multiplying HCRU by published average costs for each medical resource.

Evaluated were 248 cases (median age 56.5 years, 57.3% female, 52.4% treated with sleep-related medications) and 248 matched controls (median age 55.0 years, 56.0% female, 100.0% treated with sleep-related medications). Over the course of 24 months post-initiation, cases had significantly lower incidences of inpatient stays (55% lower, IRR: 0.45; 95% CI: 0.28–0.73; P=0.001), significantly fewer emergency department (ED) visits without inpatient admission (59% lower; IRR: 0.41; 95% CI: 0.27–0.63; P<0.001), and significantly fewer hospital outpatient visits (36% lower; IRR: 0.64; 95% CI: 0.49–0.82; P<0.001). There was also a trend for fewer ambulatory surgical center visits (23% lower; IRR: 0.77; 95% CI: 0.52–1.14; P=0.197) and fewer office visits (7% lower; IRR: 0.93; 95% CI: 0.81–1.07; P=0.302) with the use of SHUTi. Use of sleep medications was more than four times greater in controls vs. cases, with 9.6 (95% CI: 7.88–11.76) and 2.4 (95% CI: 1.91–2.95) prescriptions/patient, respectively (P<0.001). All-cause per-patient HCRU costs were $8,202 lower over 24 months for cases vs. controls, driven primarily by a lower incidence of hospitalizations (-$4,996 per patient) and hospital outpatient visits (-$2,003 per patient).

Patients with chronic insomnia who used a digital CBTi treatment had significant and durable real-world reductions in hospital inpatient stays, ED visits, hospital outpatient visits, and office visits compared to matched controls treated with medications.

Pear Therapeutics (US), Inc.

Teaching anxiety disorder among college English teachers is a common phenomenon that negatively affects their teaching effectiveness and professional development. The study aims to analyze the relationship between teaching anxiety disorder and teachers’ development, and to provide new ideas for solving teachers’ anxiety disorder.

English teachers in several colleges and universities in a certain area were selected as the subjects of the study, and data were collected by questionnaire survey, with a total of 100 teachers participating in the study and 100 questionnaires recovered; the questionnaires included the assessment of the level of teaching anxiety, the assessment of the degree of teachers’ development, and the collection of individual information.

After completing the questionnaire, the data collected from the questionnaire results were analyzed using SPSS 22.0 software, which indicated that the average level of teaching anxiety and the degree of development of the teachers were 3.8 and 3.2, respectively. Further analysis revealed that there was a significant negative correlation between the level of teaching anxiety and the degree of development of the teachers (r=-0.56, P<0.01), indicating that the higher the level of teaching anxiety disorder, the lower the degree of teacher development.

There is a close relationship between teaching anxiety disorder and teacher development among college English teachers, and increased levels of teaching anxiety disorder can affect teachers’ teaching performance, impede their reflective practice and limit their professional growth.

This study explored the therapeutic effect of Chinese moral and ethical education combined with sertraline hydrochloride on college students’ depression. It is to find an economical, convenient, and efficient treatment to help students get rid of depression.

In a tertiary level hospital, 90 patients with depression who are studying in university were selected as the experimental subjects. The patients were randomly divided into combination group and drug group by computer. For patients in the drug group, one sertraline hydrochloride tablet was taken daily during the treatment period. For patients in the combination group, half an hour of Chinese moral and ethical education was conducted every day on the basis of the drug group. Before and after the experiment, the self-rating depression scale (SDS) was used to evaluate the treatment effect of depression in the combination group and drug group.

Before the experiment, the scores of the combination group and drug group were 68.42 ± 6.53 and 69.05 ± 4.49, respectively, with no significant difference (P > 0.05). After a period of treatment, the score of the combination group was significantly lower than that of the drug group (P < 0.05), as shown in Table 1.Table 1.

Score of combination group and drug group

It can be seen from the existing reports that the current rate of college students suffering from depression is increasing year by year, which greatly affects the normal work and study of students. Therefore, the study used Chinese moral and ethical education combined with sertraline hydrochloride drug therapy to intervene the depressive symptoms of college students. The results showed that after a period of treatment, the score of the combination group was significantly lower than that of the drug group (P < 0.05). This shows that the treatment proposed by the study can effectively treat college students’ depression.

The research is supported by: Key Project of Social Science Funds of Liaoning Province, “Research on the Loyalty and Its Influencing Factors of the People’s Police” No. L17ASH001; Major Cultivation Project of Basic Scientific Research Funds of Central Universities “Research on the Status, Role and Realization Path of Ideological and Political Courses in Public Security Universities in” Political Police Building” No. 3242020019.

The problem of anxiety disorders among college students is becoming more and more prominent at present. The study aims to explore the influence of traditional folk art combined with modern art teaching on alleviating college students’ anxiety disorders.

100 college students in a university were selected as the subjects of the study, and they were divided into an experimental group and a control group, with 50 students in each group. The experimental group received traditional folk art combined with modern art teaching, and the control group continued traditional teaching. SPSS22.0 software was utilized for data processing, and methods such as anxiety scores and significance tests were applied to assess the teaching effect.

The study utilized the Hamilton Anxiety Scale for scoring and found that the anxiety scores of the study participants in the control and experimental groups ranged from 15-23. The study found that the anxiety scores of the college students in the experimental group were significantly lower than those of the control group (M=3.45 for the experimental group and M=4.92 for the control group, P<0.001). The results of the study show that traditional folk art combined with modern art teaching has a significant effect on relieving college students’ anxiety.

Traditional folk art combined with modern art teaching has achieved a positive impact on alleviating college students’ anxiety disorders, which can improve their mental health and promote their personal development.

Mania is one of the common diseases in psychiatric department. With the accelerating pace of life, people are facing more and more pressure. Mental disorders and mentally ill patients are also increasing, especially in the student group. Patients with mania may have clinical symptoms such as self-talk and exaggerated actions, and depression. Seriou’s mania has a great impact on students’ life and mental state. In schools, teachers are more required to carry out correct ideological education and psychological counseling for students. Therefore, the research is conducted from the ideological education of college teachers and staff to improve students or treat students’ mania symptoms.

108 manic patients were selected from 3 colleges and universities to participate in the designed manic intervention experiment. In the experiment, the subjects were divided into experimental group and control group. The control group was treated with routine relaxation training; The experimental group was treated with ideological education and regular relaxation training. The results were reflected by the Bech Rafaelsdn Mania Rating Scale (BRMS), Hamilton Anxiety Scale, and Depression Scale.

Table 1 shows the results of manic scale scores in the intervention experiment. In Table 1, the BRMS score of the control group decreased from 25.46 before the experiment to 18.25, with a decrease of 7.21 points; The BRMS score of the experimental group decreased from 24.53 before the experiment to 12.15, a decrease of 12.38 points.Table 1.

RBMS score results of intervention experiment

Through the ideological education of college teachers and staff, the research conducted intervention treatment on students’ mania, and compared the decline trend of the scores of the two groups. The decline trend of the experimental group was more obvious. The method adopted by the experimental group was more effective in the treatment of students’ mania. It shows that the ideological education of teaching staff plays an important role in the mental health of students. Colleges and universities should give full play to the role of ideological education to ensure the mental health of students.

The research is supported by: Research Project on Undergraduate Teaching Reform of Liaoning Ordinary Undergraduate Higher Education, 2022 “Research on the Reform of the Open and Shared Management Mode of Multidisciplinary Laboratories in the National Experimental Teaching Demonstration Center of Fashion Design and Engineering” No. LNJXGG2022-371.

Cognitive impairment is a major determinant of poor functional outcome in schizophrenia and there are currently no available pharmacotherapies. Deficits in glutamatergic signaling play a key role in the neuropathology of cognitive symptoms. Iclepertin (BI 425809), an inhibitor of glycine transporter-1, enhances glutamatergic signaling by increasing synaptic levels of the N-methyl-D-aspartate receptor co-agonist, glycine. A 12-week, Phase II trial (NCT02832037) in 509 patients with schizophrenia demonstrated that iclepertin was well tolerated and significantly improved cognition. The Phase III CONNEX program aims to confirm the efficacy, safety, and tolerability of iclepertin in improving cognition and functioning in a larger cohort of patients.

CONNEX consists of three replicate randomized, double-blind, placebo-controlled parallel-group trials in patients with schizophrenia (NCT04846868, NCT04846881, NCT04860830) currently stable on antipsychotic treatment. Each trial aims to recruit ~586 patients, 18–50 years old, treated with 1–2 antipsychotic medications (≥12 weeks on current drug; ≥35 days on current dose prior to treatment), who have functional impairment in day-to-day activities, and interact ≥1 hour per week with a designated study partner. Patients with cognitive impairment due to developmental, neurological, or other disorders, or receiving cognitive remediation therapy within 12 weeks prior to screening, will be excluded. Patients will be recruited from multiple centers across 32 countries in Asia, North and South America, and Europe, and randomized 1:1 to receive either oral iclepertin 10 mg (n=293), or placebo (n=293) once daily over 26 weeks. The primary efficacy endpoint is change from baseline (CfB) in the MATRICS Consensus Cognitive Battery overall composite T-score. Key secondary efficacy endpoints are CfB in Schizophrenia Cognition Rating Scale total score and CfB in the adjusted total time in the Virtual Reality Functional Capacity Assessment Tool. Long-term safety and tolerability data will be collected in an open-label safety extension study (CONNEX-X).

The studies are currently recruiting (first patients enrolled Aug–Sept 2021), with completion expected in Q2 2024. Here we present an overview of the current study status, including any information relating to screening failures, and the experience of collecting these data as part of a large multi-country, multi-center study.

To date, most large, industry-sponsored studies testing various compounds to address cognitive function have failed to show proof-of-clinical concept. Demonstration of efficacy of iclepertin in improving cognition in this Phase III program would provide important insight into the role of glutamate in cognitive symptoms that may also have relevance for other cognitive disorders. Iclepertin may represent the first efficacious medication for cognitive impairment associated with schizophrenia.

Boehringer Ingelheim International GmbH (1346-0011, NCT04846868; 1346-0012, NCT04846881; 1346-0013, NCT04860830)

There are currently no approved pharmacotherapies to treat cognitive impairment associated with schizophrenia (CIAS). Iclepertin (BI 425809) is a novel glycine transporter-1 inhibitor under development for treatment of CIAS. A previous study demonstrated pro-cognitive effects of iclepertin in patients with schizophrenia; however, concurrent cognitive stimulation could in theory enhance any pro-cognitive pharmacological effects on neuroplasticity. We present preliminary demographics and baseline data from a trial exploring the efficacy of iclepertin together with at-home computerized cognitive training (CCT).

This is an ongoing Phase II, double-blind, placebo-controlled, parallel-group trial in patients with schizophrenia on stable antipsychotic therapy across ~58 centers in 6 countries. Patients aged 18–50 years, compliant with CCT during the run-in period (completing ≥2 hours/week for 2 weeks), were randomized (1:1) to receive once-daily iclepertin 10 mg or placebo together with CCT for 12 weeks. Thereafter, minimum compliance for at-home CCT is 1 hour/week, with a target of ~30 hours across 3–5 sessions totaling 2.5 hours/week. Patients have been stratified to balance potential effects of age (18–40; 41–50 years). Primary endpoint is change from baseline (CfB) in neurocognitive composite T-score of the MATRICS Consensus Cognitive Battery (MCCB) at Week 12. Secondary endpoints include CfB in the Schizophrenia Cognition Rating Scale (SCoRS) total score, MCCB overall composite T-score, and Positive and Negative Syndrome Scale (PANSS) total scores. Novel exploratory endpoints include the Virtual Reality Functional Capacity Assessment Tool to assess daily functioning and the Balloon Effort Task to assess motivation in cognitive performance.

Of the planned sample of 200 randomized patients, the overall treated population currently includes 183: 67% (n=122) are male; mean (standard deviation [SD]) age and time since first diagnosis are 38.2 (7.9) years and 13.5 (8.5) years. Overall, 49% (n=89) are White and 43% (n=79) are Black or African American; 80% (n=147) are from North America, 15% (n=28) from Europe, and 4% (n=8) from Australia/New Zealand. Mean (SD) baseline MCCB neurocognitive composite and overall T-scores (n=178) are 33.7 (11.9) and 32.5 (12.6). Mean (SD) baseline SCoRS total score (n=167) is 35.2 (8.7). Mean (SD) baseline PANSS total and negative symptom scale scores (n=183) are 64.7 (14.6) and 17.3 (5.4). Median (Q1, Q3) CCT compliance over the on-treatment period for patients who have completed or discontinued early is 2.00 (1.21, 2.51) hours/week.

This trial is, to our knowledge, the largest of its kind combining daily pharmacotherapy for CIAS with at-home CCT. It will indicate whether iclepertin together with concurrent cognitive stimulation provides enhanced cognitive benefit, and whether any improvements in neurocognition can translate into improved measures of daily functioning in patients.

Boehringer Ingelheim International GmbH (NCT03859973/1346-0038)

The research object of consumer psychology is consumers. By studying the psychological and behavioral changes of consumers in the process of consumption, we can summarize relevant consumption laws and apply them to commercial operations to improve sales performance. The rapid development of e-commerce has promoted the continuous development of cross-border e-commerce. Many consumers are keen on overseas fashion brands and have bought a large number of fashion brand clothing and other products without considering the actual use of the goods, thus causing anxiety and regret for their excessive consumption afterwards. In this kind of consumer groups, college students are very easy to appear excessive consumption behavior. Therefore, the article analyzes the impact of cross-border e-commerce on consumer behavior anxiety and behavior from the perspective of consumer psychology.

The study selected college students in the consumer group as the research object, and randomly selected 460 college students from different genders, ages, majors, etc. These students have different consumer psychologies and behaviors. Types of overseas shopping commodities, reasons for purchasing and students’ views on cross-border e-commerce platforms were recorded and analyzed. The impact of cross-border e-commerce on consumer behavior anxiety and behavior was explored, and the reasons for college students’ anxiety, and use 1-5 grades were analyzed. The data processing software is Statistic software.

After statistical processing, the anxiety level of college students in different genders with different issues of cross-border e-commerce platforms is shown in Table 1. In Table 1, students of different genders have different anxiety levels on different issues of cross-border e-commerce platforms. Different from male college students, female college students have more anxiety about high fake products and false propaganda (P < 0.05).Table 1.

Anxiety of college students of different genders

The development of cross-border e-commerce has brought more goods to consumers and promoted their consumption, but at the same time, there are also some drawbacks, such as exaggerated publicity, false publicity, etc., which has led to consumers’ excessive consumption, led to the emergence of college students’ “borrowing and lending” behavior, and increased their anxiety. While consumers need rational consumption and financial management, cross-border e-commerce should guarantee after-sales service and establish a good reputation.

College education plays an important role in moral development and values, but some students may face mood disorders. Interventions in educational psychology can help students overcome obstacles and achieve well-rounded development.

Students at one university were selected for the study, and data were collected using questionnaires and tools such as the Stanford Acute Stress Response Questionnaire (SASRQ) and 3-Minute Disorder Assessment Scale (3D-CAM). The experiment focused on students’ moral judgment, behavior, sense of burnout, sense of self-responsibility and emotional state. The data were processed by State statistical software.

The results show that there are some differences in moral judgment and behavior of the students. Some students show burnout, lack of self-responsibility and emotional instability. Specific data are as follows: The mean score of moral judgment was 3.82 (SD =0.56), the mean score of behavioral performance was 4.05 (SD =0.61), the mean score of burnout was 2.94 (SD =0.72), the mean score of self-responsibility was 3.17 (SD =0.68), and the mean score of emotional state was 2.75 (SD =0.59).

The application of educational psychology in college education can take intervention measures. Developing educational programs and activities aims at character development to enhance moral judgment and behavior. For students with mood disorders, psychological counseling and support are provided to help overcome burnout, enhance the sense of self-responsibility, and adjust emotions. The Stanford Acute Stress Response Questionnaire (SASRQ) and 3-Minute Disorder Assessment Scale (3D-CAM) can assess mood disorders and psychological states and provide a basis for intervention.

During the study period in college, students often suffer from depression because of serious psychological depression. When suffering from depression, it is difficult for college students to make effective self-adjustment. This will reduce their sense of self-efficacy, and ultimately lead to college students’ difficulty in effectively relieving their depression. The research points out that psychological intervention can specifically reduce college students’ depression, improve their well-being status, and then enhance their sense of self-efficacy, and promote college students’ rehabilitation.

The study took 108 students with depression admitted to a university hospital as subjects, and randomly divided them into group A and group B. The students in group A were treated with routine psychological intervention, and the students in group B were treated with college medical guidance on the basis of psychological intervention. Hamilton Depression Scale (HAMD) of the two groups was observed. General Self-Efficacy Scale (GSES) was used to analyze the change of self-efficacy of the two groups, and the questionnaire survey was conducted to evaluate students’ coping style.

The HAMD and GSES scores of the two groups of students were shown in Table 1. The results showed that there was a significant difference between the two groups in the scores after intervention.Table 1.

Differences between the two groups of students before and after intervention

The self-efficacy of college students with depression has seriously affected their rehabilitation effect. Therefore, the study proposed a psychological intervention strategy combined with college medical guidance. In the effect evaluation, the psychological intervention strategy of medical guidance in colleges and universities can significantly reduce the students’ depression scores and enhance their sense of self-efficacy. Therefore, in college teaching, we need to make full use of college medical guidance to improve the effect of psychological intervention and alleviate students’ depression.

The research is supported by: Sichuan Basic Education Research Center, Research on the carrier of patriotism education practice in primary and middle schools (No. 20SZSJYZ-03).

Mood disorders are important factors affecting the performance stability of piano players. The purpose of this study is to explore the influence of psychological anxiety on the stability of competition performance.

Piano players with different mood disorders were selected as research objects. The Stanford Acute Stress Response Questionnaire (SASRQ) and a similar 3-minute Disorder Assessment Scale (3D-CAM) were used to assess the participants’ state of psychological anxiety. By collecting the data before and after the competition, BMDP statistical method was used to compare the performance stability of piano players under different mood disorder levels.

The results showed that before the competition, the piano players in the high mood disorder group exhibited higher levels of psychological anxiety (SASRQ score of 7.8 on average), while the low mood disorder group had relatively lower levels of psychological anxiety (SASRQ score of 3.2 on average). After the competition, the high mood disorder group had lower performance stability (mean score 6.5), while the low mood disorder group had relatively higher performance stability (mean score 8.9).

The results show that mood disorders have significant effects on the level of psychological anxiety and the stability of piano players in competition. Players with high levels of mood disorders may be more susceptible to psychological stress during competitions, which can affect the stability of their performance. Therefore, psychological support and intervention measures should be provided to piano players to help them overcome mood disorders and improve the quality of performance during competitions.

Obstructive sleep apnea (OSA) is a highly prevalent sleep disorder that is often associated with numerous medical and psychiatric comorbidities. Patients with OSA experience a variety of symptoms that can be burdensome and affect their quality of life and satisfaction with care. Excessive daytime sleepiness (EDS) is a common symptom of OSA, and can persist despite primary airway therapy (e.g., positive airway pressure [PAP]). This analysis aimed to characterize common comorbidities, as well as symptoms present at OSA diagnosis and their burden in a real-world population of participants with OSA.

US residents (≥18 years of age, self-reported clinician diagnosis of OSA [from 1/1/2015 to 3/31/2020]) completed a survey in Evidation Health’s Achievement app that assessed self-reported sleepiness (Epworth Sleepiness Scale [ESS]), self-reported PAP usage, self-reported physician-diagnosed comorbidities, and information on their symptoms at time of OSA diagnosis. Self-reported PAP use was categorized as nonuse (no PAP use), nonadherent (<4 h/night or <5 d/wk), intermediate (4–6 h/night, ≥5 d/wk), or highly adherent (≥6 h/night, ≥5 d/wk). EDS was defined as ESS score >10. All data were summarized descriptively.

In total, 2289 participants completed the survey (50.3% female; 82.5% White; mean ± standard deviation [SD] age, 44.8 ± 11.1 years; mean ± SD age at OSA diagnosis, 40.7 ± 11.4 years; mean ± SD body mass index, 35.4 ± 8.7 kg/m2); 42.5% had EDS. Among the total population, 30.6% were PAP non-users, 6.7% were nonadherent, 9.8% were intermediate adherent, and 52.9% were highly adherent. Across the study population, the most common self-reported physician-diagnosed comorbidities were anxiety (44%) and depression (42%) followed by hypertension (39%), dyslipidemia (26%), and asthma (21%). Among the symptoms participants reported having had at the time of OSA diagnosis, the most common were EDS (79%), fatigue (79%), snoring (75%), and awakening with a dry mouth or sore throat (63%). Concentration/Memory problems (48%) and mood changes (46%) were also common. In the overall population, the symptoms present at the time of OSA diagnosis that were most likely to be highly burdensome were fatigue (53%), EDS (46%), snoring (35%), difficulty concentrating/memory issues (31%), and mood changes (25%).

These real-world survey data identify anxiety and depression as the most frequently reported comorbidities in a population of participants with OSA, each affecting over 40% of participants. In addition to classic OSA symptoms (e.g., EDS, fatigue, snoring, and awakening with dry mouth/sore throat), concentration/memory problems and mood changes were also common at the time of OSA diagnosis and were among the presenting symptoms most frequently reported as highly burdensome, along with fatigue, EDS, and snoring.

Axsome Therapeutics and Jazz Pharmaceuticals

Ideological and political education, as an important part of cultivating students’ correct world outlook and values, has attracted much attention. However, there is a lack of sufficient research into the influence of first-class ideological and political education courses on students’ learning anxiety.

This study took the first-class curriculum innovation of ideological and political education as the research direction, selected students receiving ideological and political education as the research objects, and used tools such as Stanford Acute Stress Response Questionnaire (SASRQ) and 3-minute Disorder Assessment Scale (3D-CAM) to assess students’ learning anxiety symptoms. The State statistical analysis method was used to compare the changes of learning anxiety symptoms of students before and after receiving ideological and political education.

The results showed that before receiving ideological and political education, students had more common symptoms of learning anxiety (SASRQ score was 7.2 on average). After receiving ideological and political education, students’ learning anxiety symptoms improved significantly (SASRQ score was 4.8 on average), showing an obvious downward trend.

The research shows that the innovation of the first-class curriculum of ideological and political education has a positive effect on students’ learning anxiety symptoms. Through the study of ideological and political courses, students can reduce anxiety and improve social, thinking and value cognition. Therefore, attaching importance to the innovation of ideological and political education and providing support measures in higher education can help alleviate the symptoms of students’ learning anxiety and promote their all-round development.

Phased research results of Guangdong Ocean University Student Party and League and class construction studio.

Obstructive sleep apnea (OSA) is a sleep disorder that is highly comorbid with psychiatric disorders, including depression and anxiety. Excessive daytime sleepiness (EDS) is common in psychiatric disorders and OSA. In participants with OSA, EDS can persist despite use of positive airway pressure (PAP) therapy. This analysis of real-world data aimed to describe EDS and its relationship with PAP use in participants with and without depression.

US residents (≥18 years of age, self-reported physician diagnosis of OSA [from 1/1/2015 to 3/31/2020]) completed a survey in Evidation Health’s Achievement app assessing subjective levels of sleepiness (Epworth Sleepiness Scale [ESS]) and self-reported PAP usage, categorized as nonuse (no PAP use), nonadherent (<4 h/night or <5 d/wk), intermediate (4-6 h/night, ≥5 d/wk), or highly adherent (≥6 h/night, ≥5 d/wk). ESS score >10 defined EDS. A linear model assessed relationships between PAP use and ESS score. P-values are uncontrolled for multiplicity (nominal).

In total, 2289 participants (EDS, n=972; no EDS, n=1317) completed the survey (50.3% female; 82.5% White; mean±standard deviation [SD] age, 44.8 ± 11.1 years). Anxiety and depression were the most common comorbidities and were more common in participants with EDS (49% and 49%, respectively) than those without EDS (41% and 37%, respectively). Overall, EDS was more common among participants with comorbid depression (49%) than those without (38%), even among highly adherent PAP users (46% vs 30%, respectively). In a linear model (PAP users only), an additional 1 h/night of PAP use was associated with lower ESS scores in the subgroup of participants without depression (n=928; estimate [SE], −0.42 [0.09]; P<0.05), but not in the subgroup with depression (n=661; estimate [SE], −0.15 [0.10]; P>0.05). In a sensitivity analysis that excluded participants using medications that cause sleepiness, PAP use was associated with lower ESS scores regardless of depression status; however, EDS remained more common in participants with comorbid depression (46%) than in those without (36%).

In this real-world population of participants with OSA, those with EDS were more likely to have comorbid anxiety or depression. EDS was more common in participants with comorbid depression than those without, even with highly adherent PAP use. PAP use was associated with lower ESS scores in participants without comorbid depression, but not in those with comorbid depression; the use of medications that cause sleepiness may contribute to but does not fully explain this phenomenon.

Axsome Therapeutics and Jazz Pharmaceuticals

In view of the problem that the psychological barriers of ski jumpers before competitions affect the athletes’ performance on the competition ground, this paper discusses the therapeutic effect of psychological training on the athletes’ psychological barriers before competitions, so as to find a reasonable and effective intervention method to help athletes avoid psychological barriers.

40 ski jumpers were selected as the research objects. With the help of computer, they were randomly divided into two groups. One group was the psychological training group, and 60 times of psychological training were carried out in the 6-month experiment. The other group was General group without any intervention. At the beginning and end of the experiment, the Trait Anxiety Inventory for Sport (TAIS) was used to compare the pre competition psychological disorders of the two groups of athletes.

The score of the TAIS scale of the two groups after intervention was recorded and compared, as shown in Table 1. As can be seen in Table 1, the average and total TAIS scores of members of the General group are relatively high. Taking dimensional movement tension tendency as an example, the average score of the General group was 12.5. The average score and total score of TAIS in the psychological training group were significantly lower than those in the General group. Taking dimensional movement tension tendency as an example, the average score of the psychological training group was 10.2.Table 1.

The score of the TAIS scale of the members of the psychological training group before and after the intervention

Psychological barriers will have a significant impact on the patient’s cognition, emotion, and behavior. In sports competitions, psychological barriers will greatly affect the performance of athletes. In view of this problem, the study took 40 ski jumpers as the research object and discussed the effect of psychological training on the treatment of athletes’ psychological disorders before competitions. The experimental results showed that the TAIS score of the psychological training group decreased significantly after the intervention, which indicated that psychological training could effectively help the athletes to avoid psychological obstacles before the competition, so as to give full play to the athletes’ due level.

With the spread of COVID-19, in application-oriented undergraduate colleges, the difficulty of teaching work for “double-qualified” teachers has greatly increased, resulting in enormous work pressure for some teachers, which is not conducive to the development of teaching work and the physical and mental health of teachers.

Twenty “double qualified” teachers from a domestic finance and economics college were selected and divided into an experience group and a control group. The evaluation index system of college teachers’ competency and anti-pressure ability is constructed by using hesitant fuzzy language. Teachers in the experience group were trained in positive psychology, and their competency and anti-pressure ability were evaluated before and after the experiment using the evaluation model. The evaluation grade is divided into poor, general, relatively good, good and excellent, and is assigned with integers 1-5 respectively. The measurement type data is displayed in the form of mean ± standard deviation, and the t difference significance test is conducted. The difference significance level is 0.05.

After completing the experiment, the statistics are shown in Table 1. Observation Table 1 shows that before the experiment, the P value of the t-test for the competency and compression resistance scores of the two groups of teachers is far greater than 0.05, with no significant difference. However, after the completion of the experiment, the average scores of teachers’ competency and compressive capacity in the experience group were 4.52 and 4.63, respectively, higher than those in the control group, and the P value of the t-test was 0.001, which was considered significant.Table 1.

Comparison of competence and compressive ability scores of two groups of “double qualified” financial teachers

This research carried out experiments to verify the effect of positive psychological intervention on improving the competency and psychological pressure resistance of “double qualified” teachers. The experimental results showed that the post-competence and anti-pressure ability of the financial “double qualified” teachers in the experience group after positive psychological intervention were higher than those in the control group, and the difference was significant. The experimental results show that positive psychology training is conducive to improving the negative psychological pressure resistance of the “double qualified” teachers in China, so as to enhance their post competency.

Genetics, environment, and lifestyle each contribute to human behaviors. We have developed a direct-to-consumer genetic assay (Mental Health Map) that allows users to explore their genetic behavioral predispositions and potential interventions that may positively influence mental health and wellness. Based on preliminary consumer feedback suggesting increased desire to take action on their mental health and wellness, we initiated a pilot study to assess several measures of mental health and self-care in individuals both before and after reviewing their Mental Health Map.

This was a virtual case series in adults who purchased a Mental Health Map. Subjects served as their own control based on survey responses leading up to genetic testing and up to 7 weeks after an introductory coaching session. Coaching included a demonstration of how to navigate the interactive online report, discussion of key results, and provision of additional external resources as appropriate. The co-primary measures were changes in quality of life as measured by WHO-5, report of initiating a discussion or seeking mental health care with a health care provider, report of initiating and sustaining positive lifestyle changes, and subjective improvements in stress management, sleep quality, mood, focus, and social interactions. Secondary measures were changes in GAD-7 and PHQ-9.

Twenty-seven individuals completed the study. Average WHO-5 at baseline was 41.2 which numerically increased to 48.3 at week 7, suggesting improved quality of life, but this effect was not statistically significant. 42.3% of individuals were in treatment with a mental health provider at the time of survey. Of those not in treatment, 33.3% were actively seeking professional mental healthcare prompted by the coaching session. At week 6, 87% of survey respondents (n=15) asserted that they continued to make lifestyle changes that improved stress; 74% made changes to improve mood and 80% made changes that improved their habits. Percentage of respondents who reported lifestyle changes to improve sleep, focus, and social interactions were all less than 70%. In secondary outcomes, average GAD-7 at baseline was 8.9 and decreased to 6.7 at week 7, while PHQ-9 averaged 10.3 at baseline and decreased to 7.5 at week 7. Neither of the secondary outcome measures achieved a statistically significant difference.

Despite the small patient population, this pilot study provides proof-of-concept that Mental Health Map and the accompanying coaching session encourages participants to make positive lifestyle changes and prompts pursuit of a healthcare professional. We also saw numerical trends toward modest improvements in quality of life, anxiety, and depression symptoms, although these differences were not statistically significant, and may require larger sample sizes.

Genomind