Contents

pp v-viii

Contributors

pp ix-xiv

Part I - General Principles of Cell Death

1 - Human Caspases – Apoptosis and Inflammation Signaling Proteases

pp 1-10

2 - Inhibitor of Apoptosis Proteins

pp 11-22

3 - Death Domain–Containing Receptors – Decisions between Suicide and Fire

pp 23-36

4 - Mitochondria and Cell Death

pp 37-43

5 - The Control of Mitochondrial Apoptosis by the BCL-2 Family

pp 44-50

6 - Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival

pp 51-62

7 - Autophagy – The Liaison between the Lysosomal System and Cell Death

pp 63-73

8 - Cell Death in Response to Genotoxic Stress and DNA Damage

pp 74-87

9 - Ceramide and Lipid Mediators in Apoptosis

pp 88-105

10 - Cytotoxic Granules House Potent Proapoptotic Toxins Critical for Antiviral Responses and Immune Homeostasis

pp 106-122

Part II - Cell Death in Tissues and Organs

11 - Cell Death in Nervous System Development and Neurological Disease

pp 123-134

12 - Role of Programmed Cell Death in Neurodegenerative Disease

pp 135-144

13 - Implications of Nitrosative Stress-Induced Protein Misfolding in Neurodegeneration

pp 145-152

14 - Mitochondrial Mechanisms of Neural Cell Death in Cerebral Ischemia

pp 153-163

15 - Cell Death in Spinal Cord Injury – An Evolving Taxonomy with Therapeutic Promise

pp 164-175

16 - Apoptosis and Homeostasis in the Eye

pp 176-181

17 - Cell Death in the Inner Ear

pp 182-193

18 - Cell Death in the Olfactory System

pp 194-200

19 - Contribution of Apoptosis to Physiologic Remodeling of the Endocrine Pancreas and Pathophysiology of Diabetes

pp 201-220

20 - Apoptosis in the Physiology and Diseases of the Respiratory Tract

pp 221-230

21 - Regulation of Cell Death in the Gastrointestinal Tract

pp 231-239

22 - Apoptosis in the Kidney

pp 240-249

23 - Physiologic and Pathological Cell Death in the Mammary Gland

pp 250-272

24 - Therapeutic Targeting Apoptosis in Female Reproductive Biology

pp 273-282

25 - Apoptotic Signaling in Male Germ Cells

pp 283-294