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12 - Role of Programmed Cell Death in Neurodegenerative Disease

from Part II - Cell Death in Tissues and Organs

Published online by Cambridge University Press:  07 September 2011

Douglas R. Green
By
Dale E. Bredesen
Edited by
John C. Reed
Douglas R. Green
Affiliation:
St. Jude Children's Research Hospital, Memphis, Tennessee
Dale E. Bredesen
Affiliation:
University of California – San Francisco
John C. Reed
Affiliation:
Sanford-Burnham Medical Research Institute, La Jolla, California
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Summary

Introduction: Programmed cell death, cell death signaling, and neurodegenerative disease

Many of the diseases that affect the nervous system feature an abnormality of cell death of one sort or another. For example, developmental and neoplastic disorders of the nervous system feature dysregulation of the intrinsic cellular programs that mediate cell death. Furthermore, there is increasing evidence to suggest that such dysregulation may also occur in neurodegenerative, infectious, traumatic, ischemic, metabolic, and demyelinating disorders. Therefore, targeting the central biochemical controls of cell survival and death may represent a productive therapeutic approach, especially if combined with other therapeutic strategies. Furthermore, recent results from stem cell studies suggest that the fate of neural stem cells may also play an important role in disease outcomes, and therefore, cell death apparently plays a central role in many neurological diseases and potentially in their prevention and treatment.

Type
Chapter
Information
Apoptosis
Physiology and Pathology
 , pp. 135 - 144
Publisher: Cambridge University Press
Print publication year: 2011

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