Classic serotonergic psychedelics are experiencing a clinical revival, which has also revived ethical debates about psychedelic-assisted therapy. A particular issue here is how to prepare and protect patients from the vulnerability that the psychedelic state creates. This article first examines how this vulnerability manifests itself, revealing that it results from an impairment of autonomy: psychedelics diminish decision-making capacity, reduce controllability, and limit resistance to external influences. It then analyzes the strengths and weaknesses of five safety measures proposed in the literature, what aspect of the patient’s vulnerability they seek to reduce, and how they can be optimized. The analysis shows that while preparatory sessions, advance directives, and specific training and oversight are useful, starting with a lower dosage and no therapy is less so. Finally, the article presents a safety measure that has been overlooked in the literature but could be highly effective and feasible: bringing a close person to the psychedelic session.

There is a need for new imaginaries of care and social health for people living with dementia at home. Day programmes are one solution for care in the community that requires further theorisation to ensure an empirical base that is useful for guiding policy. In this article we contribute to the theorising of day programmes by using an ethnographic case study of one woman living with dementia at home using a day programme. Data were collected through observations, interviews and artefact analysis. Peg, whose case story is central in this article, was observed over a period of nine months for a total of 61 hours at the day programme, as well as 16 hours of observation at her home and during two community outings. We use a material semiotic approach to thinking about the day programme as a health ‘technology in practice’ to challenge the taken-for-granted ideas of day programmes as neutral, stable, bounded spaces. The case story of Peg is illustrative of how a day programme and its scripts come into relation with an arrangement of family care and life at home with dementia. At times the configuration of this arrangement works to provide a sort of stabilising distribution of care and space to allow Peg and her family to go on in the day-to-day life with dementia. At other times the arrangement creates limits to the care made possible. We argue that how we conceptualise and study day programmes and their relations to home and the broader care infrastructure matters to the possibilities of care they can enact.

The early months of the COVID pandemic prompted a flood of research aimed at illuminating all facets of the disease and its spread. Scholars sought to create and assess practical interventions that ranged from vaccines to government lockdown policies to workplace practices. To date, there are nearly a half-million publications on the pandemic, and more are in process.

Whether speaking two or more languages (multilingualism) or dialects of one language (bidialectalism) affect executive function (EF) is controversial. Theoretically, these effects may depend on at least two conditions. First, the multilingual and bidialectal characteristics; particularly, (second) language proficiency and the sociolinguistic context of language use (e.g., Green & Abutalebi, 2013). Second, the EF aspects examined; specifically, recent accounts of the locus of the multilingual effect propose a general EF effect rather than an impact on specific processes (Bialystok, 2017). We compared 52 “monolingual” (with limited additional-language/dialect experience), 79 bidialectal and 50 multilingual young adults in the diglossic context of Cyprus, where bidialectalism is widespread and Cypriot and Standard Greek are used in different everyday situations. Three EF processes were examined via seven tasks: inhibition, switching and working memory (Miyake et al., 2000). We found better multilingual and bidialectal performance in overall EF, an effect moderated by high (second) language proficiency.

We analyze the process M(t) representing the maximum of the one-dimensional telegraph process X(t) with exponentially distributed upward random times and generally distributed downward random times. The evolution of M(t) is governed by an alternating renewal of two phases: a rising phase R and a constant phase C. During a rising phase, X(t) moves upward, whereas, during a constant phase, it moves upward and downward, continuing to move until it attains the maximal level previously reached. Under some choices of the distribution of the downward times, we are able to determine the distribution of C, which allows us to obtain some bounds for the survival function of M(t). In the particular case of exponential downward random times, we derive an explicit expression for the survival function of M(t). Finally, the moments of the first passage time $\Theta_w$ of the process X(t) through a fixed boundary $w>0$ are analyzed.

The work of Ronald Dworkin was central to the development of twentieth-century anglophone legal philosophy. This article offers the first discussion of a previously unknown and unpublished book manuscript by Dworkin which shows that he initially grounded his early legal thought in a wide-ranging methodological framework centered on ordinary language philosophy. Amidst heated debates over the draft for the Vietnam War, Dworkin developed a modified version of ordinary language analysis which, he contended, facilitated a critical stance towards what he called “conventional morality.” In this light, the widely acknowledged influence of the legal process school on Dworkin's early work appears as a transition from an earlier engagement with ordinary language philosophy. I conclude by tracing how Dworkin shifted towards the legal process school and how this reshaped the theoretical ambitions of his legal thought.

The COVID-19 pandemic has clearly demonstrated that international cooperation to combat pandemics is insufficient. The World Health Organization has, therefore, recently reformed the International Health Regulations based on the experience of the COVID 19-pandemic. The World Health Assembly also plans to adopt a new Pandemic Agreement to further strengthen international cooperation. However, negotiations have not yet been successful, and this year’s World Health Assembly agreed to extend the negotiations for the Pandemic Agreement by one year. Reason enough to analyse and critically evaluate the reform efforts in detail, and to give an outlook on the future of international pandemic law.

Mask mandates were controversial policies during the pandemic. Although there is considerable research on the benefits of masks, there has been no research on the distribution of perceived costs of compliance with mask mandates. This article presents the results from a hypothetical set of questions related to mask-wearing behavior and opinions that were asked of a nationally representative sample of over 4,000 participants in early 2022. We use survey valuation methods to assess how much participants would be willing to pay to be exempted from rules of mandatory community masking. The survey asks specifically about a 3-month exemption. We find that the majority of respondents (56%) are not willing to pay to be exempted from mandatory masking. However, the average person was willing to pay $525, and a small segment of the population (0.9%) stated they were willing to pay over $5,000 to be exempted from the mandate. Younger respondents stated higher willingness to pay to avoid the mandate than older respondents. Combining our results with standard measures of the value of a statistical life, we estimate that a 3-month masking order was perceived as cost-effective through willingness to pay questions only if at least 13,333 lives were saved by the policy.

We study original position arguments in the context of social choice under ignorance. First, we present a general formal framework for such arguments. Next, we provide an axiomatic characterization of social choice rules that can be supported by original position arguments. We illustrate this characterization in terms of various well-known social choice rules, some of which do and some of which do not satisfy the axioms in question. Depending on the perspective one takes, our results can be used to argue against certain rules, against Rawlsian theories of procedural fairness, or in support of richer, multidimensional models of individual choice.

The endorsement of conspiracy theories may be increased by subjectively perceived stress. Yet, it is not known whether this correlation is caused by the effects of the acute stress reaction on the brain or other psychological, social, or methodological factors. The effect of an experimentally induced acute stress reaction on conspiracy thinking was tested on a sample (n = 115) of students of medicine. Although the stress procedure caused a substantial increase in salivary cortisol, there was no significant effect on endorsing conspiracy theories or adopting conspiracy interpretations of novel information. The results confirmed no effect of the acute stress reaction on conspiracy thinking, suggesting it may be absent or weaker than expected. The study demonstrated the viability of psychophysiological experimental design in conspiracy research and may inspire further examination of the physiological mechanisms underlying susceptibility to conspiracy theories.

Mid-aortic syndrome is an uncommon vascular disease characterised by lower thoracic and upper abdominal aorta stenosis and can occur even in neonatal or infant periods. Here, we report an interesting case of a 2-month-old female with diffuse hypoplasia of the lower abdominal aorta and secondary dilated cardiomyopathy. In our patient, her abdominal aortic narrowing spontaneously normalised over time with the administration of consistent and goal-directed heart failure therapy, supporting adequate growth and natural recovery.

Regional cabinet members (RCMs) are key political actors in subnational politics, especially in federal systems or in countries that have undergone a process of regionalization or devolution, even though they are still less studied than federal or national ministers. Italy and its regionalization process represent an interesting case study to understand how and under what conditions members of regional cabinets can exit from politics or move upwards, or downwards the different tiers of government. By using an original dataset of 721 RCMs in ordinary statute regions we tested through multinomial regression analysis whether political and institutional or personal factors influence their movements (both legislative or executive) upward, that is, toward national and/or European positions, backward toward local (both provincial or municipal) positions or their exit from politics. Our results show that both political–institutional and individual factors matter. In particular, displaying a previous national career favors upward movements while being a technician or independent favors the exit from politics.

In Brazil, numerous participatory institutions have been suspended over the past decades, including many participatory budgeting (PB) programs at the municipal level. Since the introduction of PB in Porto Alegre in 1989, extensive literature has discussed its effects on the way urban social movements make demands. However, the suspension of many PBs across Brazil raises a new question: how do these movements adapt following the loss of an arena that had become central to their efforts? Looking at the pioneering experience of Porto Alegre’s PB, whose progressive erosion started in 2002, I argue that urban movements have since shifted away from institutionalized participation routines, and adopted new routines that combine bureaucratic activism with proximity politics. Focusing on these movements’ repertoires of interactions I argue that the erosion of PB led to the deinstitutionalization of urban social movements.

We investigate a recent model proposed in the literature elucidating patterns driven by chemotaxis, similar to viscous fingering phenomena. Notably, this model incorporates a singular advection term arising from a modified formulation of Darcy’s law. It is noteworthy that this type of advection can also be well interpreted as a description of a radial fluid flow source surrounding an aggregation of cells. For the two-dimensional scenario, we establish a precise threshold delineating between blow-up and global solution existence. This threshold is contingent upon the pressure magnitude and the initial total mass of the aggregating cells.

This paper explores the international higher education (IHE) fever gripping China's middle-class families. Drawing on data gathered from 69 qualitative interviews with Chinese middle-class international students whose education is financially supported by their families, the paper points out that the desire for IHE is influenced by the pursuit of the “normative biography,” a term conceptualized by the authors to refer to the societal expectations that prescribe the specific life milestones and sequences that young middle-class adults should follow on their life trajectories. IHE is perceived as an important pathway to help such young adults meet these social expectations. Moreover, parental support for IHE is not only an educational investment but also assists offspring in conforming to the normative biography. This paper enriches the understanding of how educational practices are influenced by broader sociocultural contexts in contemporary China.

Extensible continuum robots (ECRs) offer distinct advantages over conventional continuum robots due to their ability to enhance workspace adaptability through length adjustments. This makes ECRs particularly promising for applications that require variable lengths involving the manipulation of objects in challenging environments, such as risky, cluttered, or confined. The development of ECRs necessitates careful consideration of mechanical structures, actuation methods, methods of stiffness variability, and control methods. The selection of papers is based on their relevance to ECRs within the period of 2010 to 2023 in the databases of Scopus and Web of Science. Distinguishing itself from other review papers, this paper aims to deliver a comprehensive and critical discussion about the advantages and disadvantages of ECRs concerning their mechanical structures, actuation methods, stiffness variability, and control methods. It is a beneficial resource for researchers and engineers interested in ECRs, providing essential insights to guide future developments in this field. Based on the literature, existing ECRs exhibit an inherent trade-off between flexibility and structural strength due to the absence of systematic design methods. Additionally, there is a lack of intelligent and effective controllers for achieving complex control performance and autonomous stiffness variability.