Sun and Waterman model DNA mutations during the PCR reaction by a non-canonical branching process. Mean-field approximated values fit the simulated values surprisingly well. We prove this as a theoretical result, for a wide range of the parameters. Thus, we bound explicitly the biases, in law and in the mean, that the mean-field approximation induces in the random number of mutations of a DNA molecule, as a function of the initial number of molecules, of the number of PCR cycles, of the efficiency rate and of the mutation rate. The range where we prove that the approximation is good contains the observed mutation rates in many actual PCR reactions.
