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1 results

  • Reducing the number of animals used in behavioural genetic experiments using chromosome substitution strains

  • MC Laarakker, F Ohl, HA van Lith
  • Journal:
    Animal Welfare / Volume 15 / Issue 1 / February 2006
    Published online by Cambridge University Press:
    11 January 2023, pp. 49-54
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  • Chromosome substitution strains (also called consomic lines or strains) are strains in which a single, full-length chromosome from one inbred strain — the donor strain — has been transferred onto the genetic background of a second inbred strain — the host strain. Based on the results obtained from behavioural tests with the two parental strains, the minimum number of animals from each of the host and consomic strains that are required for a successful behavioural genetic analysis can be estimated. Correct application of statistical knowledge can lead to a further reduction in the number of animals used in behavioural genetic experiments using chromosome substitution strains.