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1 results

  • Chapter Seven - Alzheimer’s Disease and Other Disorders with Age

  • Angela Gutchess, Brandeis University, Massachusetts
  • Book:
    Cognitive and Social Neuroscience of Aging
    Published online:
    14 February 2025
    Print publication:
    13 February 2025, pp 187-215

  • Summary

    This chapter considers the changes that occur with age-related disorders. For Alzheimer’s disease and amnestic mild cognitive impairment, the chapter reviews structural changes that occur in the brain and then turns to functional changes. These include coverage of changes related to memory and cognition, attention, and self and emotion. Next, neuroimaging research on amyloid and tau are reviewed, and some literature on relevant genes is discussed. The chapter then reviews literature on other age-related neurodegenerative diseases, considering effects on cognitive and social functions. These include Parkinson’s disease, Huntington’s disease, frontotemporal dementias (including progressive nonfluent aphasia, semantic dementia, behavioral variant frontotemporal dementia, and amyotrophic lateral sclerosis).