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Chapter Seven - Alzheimer’s Disease and Other Disorders with Age

Published online by Cambridge University Press:  14 February 2025

Angela Gutchess
Angela Gutchess
Affiliation:
Brandeis University, Massachusetts
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Summary

This chapter considers the changes that occur with age-related disorders. For Alzheimer’s disease and amnestic mild cognitive impairment, the chapter reviews structural changes that occur in the brain and then turns to functional changes. These include coverage of changes related to memory and cognition, attention, and self and emotion. Next, neuroimaging research on amyloid and tau are reviewed, and some literature on relevant genes is discussed. The chapter then reviews literature on other age-related neurodegenerative diseases, considering effects on cognitive and social functions. These include Parkinson’s disease, Huntington’s disease, frontotemporal dementias (including progressive nonfluent aphasia, semantic dementia, behavioral variant frontotemporal dementia, and amyotrophic lateral sclerosis).

Keywords

Alzheimer’s diseasemild cognitive impairmentamyloidtauage-related neurodegenerative diseases
Type
Chapter
Information
Cognitive and Social Neuroscience of Aging , pp. 187 - 215
Publisher: Cambridge University Press
Print publication year: 2025

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References

For Further Reading

Budson, A. E., & O’Connor, M. K. (2021). Six Steps to Managing Alzheimer’s Disease and Dementia: A Guide for Families. New York: Oxford University Press.CrossRefGoogle Scholar
Dintica, C. S., Habes, M., Erus, G., Simone, T., Schreiner, P., & Yaffe, K. (2023). Long-term depressive symptoms and midlife brain age. Journal of Affective Disorders, 320, 436–441. https://doi.org/10.1016/j.jad.2022.09.164.CrossRefGoogle ScholarPubMed
Jack, C. R., Jr, Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., Holtzman, D. M., Jagust, W., Jessen, F., Karlawish, J., Liu, E., Molinuevo, J. L., Montine, T., Phelps, C., Rankin, K. P., Rowe, C. C., Scheltens, P., Siemers, E., Snyder, H. M., Sperling, R., … Contributors (2018). NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 14(4), 535–562. https://doi.org/10.1016/j.jalz.2018.02.018.CrossRefGoogle Scholar
Jagust, W. J., Teunissen, C. E., & DeCarli, C. (2023). The complex pathway between amyloid β and cognition: implications for therapy. The Lancet. Neurology, 22(9), 847–857. https://doi.org/10.1016/S1474-4422(23)00128-X.CrossRefGoogle ScholarPubMed
Shany-Ur, T., & Rankin, K. P. (2011). Personality and social cognition in neurodegenerative disease. Current Opinion in Neurology, 24(6), 550–555.CrossRefGoogle ScholarPubMed
Talwar, P., Kushwaha, S., Chaturvedi, M. & Mahajan, V. (2021). Systematic review of different neuroimaging correlates in mild cognitive impairment and Alzheimer’s disease. Clinical Neuroradiology, 31, 953–967. https://doi.org/10.1007/s00062-021-01057-7.CrossRefGoogle ScholarPubMed

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