A 4-yr field test was initiated in 1975 to determine susceptibility of a natural infestation of six morningglory species to herbicides which can be applied to the soil and foliage in soybeans [Glycine max (L.) Merr.]. The species studied were pitted morningglory (Ipomoea lacunosa L.), entireleaf morningglory [Ipomoea hederacea (L.) Jacq. var. integriuscula], ivyleaf morningglory [Ipomoea hederacea (L.) Jacq.], purple moonflower [Ipomoea muricata (L.) Jacq.], palmleaf morningglory [Ipomoea wrightii (Gray)], and small flower morningglory [Jacquemontia tamnifolia (L.) Griseb.]. Control with herbicides applied preplant incorporated and preemergence was dependent on morningglory species and on rainfall to allow plant uptake of the herbicide. Herbicides applied to the soil were not as effective as those applied postemergence. Oxadiazon [2-tert-butyl-4-(2,4-dichloro-5-isopropoxyphenyl)-δ2-1,3,4-oxadiazolin-5-one] gave the best and longest lasting preemergence control, averaging 79% control for all species. Preemergence control with metribuzin [4-amino-6-tert-butyl-3-(methylthio)-as-triazin-5(4H)-one] was dependent on species, with 84% control of small flower morningglory and only 26% for ivyleaf and 18% for entireleaf morningglory. At V2 (one trifoliolate) and V5 stages of soybean growth, acifluorfen {5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid} at 0.56 kg/ha applied over-the-top and oxyfluorfen [2-chloro-1-(3-ethoxy-4-nitrophenoxy)-4-(trifluoromethyl)benzene] at 0.28 kg/ha applied post-directed gave 90 and 92% control of all species, respectively. Most effective were repeated post-directed applications at V5 and V7 stages of soybean growth. Metribuzin + 2,4-DB [4-(2,4-dichlorophenoxy)butyric acid] (99%), linuron [3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea] + 2,4-DB (98%), 2,4-DB (95%), and paraquat (1,1′-dimethyl-4,4′-bipyridinium ion) + 2,4-DB (93%) provided excellent control regardless of the morningglory species.