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Données nouvelles sur la néphrotoxicitéde l’uranium

Published online by Cambridge University Press:  07 September 2012

Y. Gueguen  and
C. Rouas
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Abstract

L’uranium est un radioélément ainsi qu’un métal lourdauquel l’homme peut être exposé du fait de sa présence dans l’environnementou des activités humaines. Il exerce principalement une toxicitéchimique au niveau du tubule contourné proximal du rein après expositionaiguë ou chronique. Après exposition à une forte dose d’uranium,la néphrite tubulaire aiguë est révélée par une protéinurie ainsi qu’unediminution du débit de filtration glomérulaire. Plus récemment,l’utilisation de marqueurs d’intégrité tissulaire telle que la béta2-microglobuline ou des enzymes tissulaires a pu être corrélée auxaltérations histopathologiques des tubules contournés proximaux.Lors d’exposition chronique à de faible niveau, l’utilisation demarqueurs plus spécifiques et plus sensibles s’avère nécessairelorsque les lésions sont faibles. Des études expérimentales développéesau laboratoire ont montré la pertinence de certains de ces biomarqueurstel que Kim-1 pour détecter de faibles altérations rénales. L’uraniumexerce sa cytotoxicité au niveau des cellules épithéliales des tubules contournésproximaux probablement du fait de son entrée dans la cellule oùil s’accumule préférentiellement dans le noyau cellulaire, lorsqu’iln’est pas sous forme de précipités. Les mécanismes conduisant àla mort des cellules ne sont pas encore totalement élucidés maisle stress oxydant semble y jouer un rôle important.

Keywords

uraniumkidneytoxicityexposurenephrotoxicity
Type
Research Article
Information
Radioprotection , Volume 47 , Issue 3 , July 2012 , pp. 345 - 359
Copyright
© EDP Sciences, 2012

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References

RÉFÉRENCES

Albina, M.L. et al. (2005) Restraint stress does not enhance the uranium-induced developmental and behavioral effects in the offspring of uranium-exposed male rats, Toxicology 215, 69-79.Google Scholar
Banday, A.A. et al. (2008a) Time dependent effects of gentamicin on the enzymes of carbohydrate metabolism, brush border membrane and oxidative stress in rat kidney tissues, Life Sci. 82, 450-459.Google Scholar
Banday, A.A. et al. (2008b) Effect of uranyl nitrate on enzymes of carbohydrate metabolism and brush border membrane in different kidney tissues, Food. Chem. Toxicol. 46, 2080-2088.Google ScholarPubMed
Barbier, O. et al. (2005) Effect of heavy metals on, and handling by, the kidney, Nephron Physiol. 99, 105-110.Google ScholarPubMed
Belles, M. et al. (2007) Melatonin reduces uranium-induced nephrotoxicity in rats, J. Pineal. Res. 43, 87-95.Google ScholarPubMed
Berradi, H. et al. (2008) Renal anemia induced by chronic ingestion of depleted uranium in rats, Toxicol. Sci. 103, 397-408.Google ScholarPubMed
Blantz, R.C. (1975) The mechanism of acute renal failure after uranyl nitrate, J. Clin. Invest. 55, 621-635.Google ScholarPubMed
Brady, H.R. et al. (1989) Early effects of uranyl nitrate on respiration and K+ transport in rabbit proximal tubule, Kidney Int. 36, 27-34.Google Scholar
Carriere, M. et al. (2004) Influence of uranium speciation on normal rat kidney (NRK-52E) proximal cell cytotoxicity, Chem. Res. Toxicol. 17, 446-452.Google Scholar
Carriere, M. et al. (2008) Transmission electron microscopic and X-ray absorption fine structure spectroscopic investigation of U repartition and speciation after accumulation in renal cells, J. Biol. Inorg. Chem. 13, 655-662.Google ScholarPubMed
Cazoulat, A. et al. (2008) Urinary uranium analysis results on Gulf war or Balkans conflict veterans, Pathol. Biol. (Paris) 56, 77-83.Google ScholarPubMed
Craft, E. et al. (2004) Depleted and natural uranium: chemistry and toxicological effects, J. Toxicol. Environ. Health Part B Crit. Rev. 7, 297-317.Google ScholarPubMed
Diamond, G.L. et al. (1989) Reversible uranyl fluoride nephrotoxicity in the Long Evans rat, Fundam. Appl. Toxicol. 13, 65-78.Google ScholarPubMed
Domingo, J.L. et al. (1987) Acute toxicity of uranium in rats and mice, Bull. Environ. Contam. Toxicol. 39, 168-174.Google ScholarPubMed
Filippova, L.G. et al. (1978) Late sequelae of administering enriched uranium to rats, Radiobiologiia 18, 400-405.Google ScholarPubMed
Fleck, M. et al. (2002) Renal interstitial fibrosis (RIF): II. Ultrasound follow up study of single uranyl nitrate administration causing renal dysfunction in rats – comparison with histologic and functional renal parameters, Exp. Toxicol. Pathol. 54, 15-23.Google Scholar
Fukuda, S. et al. (2005) Toxicity of uranium and the removal effects of CBMIDA and EHBP in simulated wounds of rats, Health Phys. 89, 81-88.Google ScholarPubMed
Fukuda, S. et al. (2006) Clinical diagnostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium, Radiat. Prot. Dosim. 118, 307-314.Google ScholarPubMed
Galle, P. (1974) Role of lysosomes and mitochondria in the handling of mineral compounds by the kidney, J. Microsc. 19, 17-24.Google Scholar
Galle P. (1997) Uranium, Toxiques nucléaires, Masson (Ed.), Paris.
Ghadially, F.N. et al. (1982) Uraniosomes produced in cultured rabbit kidney cells by uranyl acetate, Virchows Arch. B Cell Pathol. 39, 21-30.Google ScholarPubMed
Gilman, A.P. et al. (1998a) Uranyl nitrate: 91-day exposure and recovery studies in the male New Zealand white rabbit, Toxicol. Sci. 41, 138-151.Google ScholarPubMed
Gilman, A.P. et al. (1998b) Uranyl nitrate: 28-day and 91-day toxicity studies in the Sprague-Dawley rat, Toxicol. Sci. 41, 117-128.Google Scholar
Goldman, M. et al. (2006) Nephrotoxicity of uranyl acetate: effect on rat kidney brush border membrane vesicles, Arch. Toxicol. 80, 387-393.Google ScholarPubMed
Gueguen, Y. et al. (2006) Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat, Arch. Toxicol. 80, 187-195.Google ScholarPubMed
Gueguen, Y. et al. (2007) Effect of acetaminophen administration to rats chronically exposed to depleted uranium, Toxicology 229, 62-72.Google ScholarPubMed
Gueguen, Y. et al. (2012) Les biomarqueurs d’atteinte rénale, Nephrol. Ther. 8 (3), 146-155.Google Scholar
Haley, D.P. (1982) Morphologic changes in uranyl nitrate-induced acute renal failure in saline- and water-drinking rats, Lab. Invest. 46, 196-208.Google Scholar
Haley, D.P. et al. (1982) The long-term effects of uranyl nitrate on the structure and function of the rat kidney, Virchows Arch. B Cell Pathol. 41, 181-192.Google ScholarPubMed
Hori, R. et al. (1985) Transport of p-aminohippurate, tetraethylammonium and D-glucose in renal brush border membranes from rats with acute renal failure, J. Pharmacol. Exp. Ther. 233, 776-781.Google ScholarPubMed
Karpas, Z. et al. (1998) Uptake of ingested uranium after low "acute intake", Health Phys. 74, 337-345.Google ScholarPubMed
Kato, A. et al. (1994) Effects of oxygen free radical scavengers on uranium-induced acute renal failure in rats, Free Radic. Biol. Med. 16, 855-859.Google ScholarPubMed
Kobayashi, S. et al. (1984) Glomerular alterations in uranyl acetate-induced acute renal failure in rabbits, Kidney Int. 26, 808-815.Google ScholarPubMed
Kurttio, P. et al. (2002) Renal effects of uranium in drinking water, Environ. Health Perspect. 110, 337-342.Google ScholarPubMed
Kurttio, P. et al. (2006) Kidney toxicity of ingested uranium from drinking water, Am. J. Kidney Dis. 47, 972-982.Google ScholarPubMed
L'Azou, B. et al. (2002) Effects of cadmium and uranium on some in vitro renal targets, Cell Biol. Toxicol. 18, 329-340.Google ScholarPubMed
La Touche, Y.D. et al. (1987) Absorption and biokinetics of U in rats following an oral administration of uranyl nitrate solution, Health Phys. 53, 147-162.Google ScholarPubMed
Leggett, R.W. (1989) The behavior and chemical toxicity of U in the kidney: a reassessment, Health Phys. 57, 365-383.Google ScholarPubMed
Leggett, R.W. et al. (1995) Fractional absorption of ingested uranium in humans, Health Phys. 68, 484-498.Google ScholarPubMed
Leggett, R.W. et al. (2003) The biokinetics of uranium migrating from embedded DU fragments, J. Environ. Radioact. 64, 205-225.Google ScholarPubMed
Linares, V. et al. (2006) Assessment of the pro-oxidant activity of uranium in kidney and testis of rats, Toxicol. Lett. 167, 152-161.Google Scholar
Maynard E.A. et al. (1949) Studies of the toxicity of various uranium compounds when fed to experimental animals, The Pharmacology and Toxicology of Uranium Compounds. Division VI, Vol. I, (C. Voegtlin and H.C. Hodge, Eds), McGraw Hill, New York, NY, pp. 309-376.
Maynard E.A. et al. (1953) Oral toxicity of uranium compounds, The Pharmacology and Toxicology of Uranium Compounds. Division VI, Vol. I, (C. Voegtlin and H.C. Hodge, Eds), McGraw Hill, New York, NY, pp. 309-376.
McDiarmid, M.A. et al. (2000) Health effects of depleted uranium on exposed Gulf War veterans, Environ. Res. 82, 168-180.Google ScholarPubMed
McDiarmid, M.A. et al. (2011) Longitudinal health surveillance in a cohort of Gulf War veterans 18 years after first exposure to depleted uranium, J. Toxicol. Environ. Health Part A 74, 678-691.Google Scholar
Milgram, S. et al. (2008) Cytotoxic and phenotypic effects of uranium and lead on osteoblastic cells are highly dependent on metal speciation, Toxicology 250, 62-69.Google ScholarPubMed
Mirto, H. et al. (1999) Intracellular behaviour of uranium(VI) on renal epithelial cell in culture (LLC-PK1): influence of uranium speciation, Toxicol. Lett. 104, 249-256.Google ScholarPubMed
Morris, K.J. et al. (1989) Studies of alveolar cell morphometry and mass clearance in the rat lung following inhalation of an enriched uranium dioxide aerosol, Radiat. Environ. Biophys. 28, 141-154.Google ScholarPubMed
Muller, D. et al. (2006) Role of the sodium-dependent phosphate co-transporters and of the phosphate complexes of uranyl in the cytotoxicity of uranium in LLC-PK1 cells, Toxicol. Appl. Pharmacol. 214, 166-177.Google ScholarPubMed
Muller, D.S. et al. (2008) Role of the sodium-dependent phosphate cotransporters and absorptive endocytosis in the uptake of low concentrations of uranium and its toxicity at higher concentrations in LLC-PK1 cells, Toxicol. Sci. 101, 254-262.Google ScholarPubMed
Nomiyama, K. et al. (1974) Assay of urinary enzymes in toxic nephropathy, Toxicol. Appl. Pharmacol. 27, 484-490.Google ScholarPubMed
Ortega, A. et al. (1989) Evaluation of the oral toxicity of uranium in a 4-week drinking-water study in rats, Bull. Environ. Contam. Toxicol. 42, 935-941.Google Scholar
Paquet, F. et al. (2004) Speciation and internal dosimetry: from chemical species to dosimetric models, Spéciation et dosimétrie interne: des espèces chimiques aux modèles dosimétriques, Radioprotection 39, 3, 341-354.Google Scholar
Paquet, F. et al. (2006) Accumulation and distribution of uranium in rats after chronic exposure by ingestion, Health Phys. 90, 139-147.Google ScholarPubMed
Prat, O. et al. (2005) Transcriptomic and proteomic responses of human renal HEK293 cells to uranium toxicity, Proteomics 5, 297-306.Google ScholarPubMed
Priyamvada, S. et al. (2010) Studies on the protective effect of dietary fish oil on uranyl-nitrate-induced nephrotoxicity and oxidative damage in rat kidney, Prostaglandins Leukot Essent Fat. Acids 82, 35-44.Google ScholarPubMed
Renault, S. et al. (2010) Uranyl nitrate inhibits lactate gluconeogenesis in isolated human and mouse renal proximal tubules: a 13C-NMR study, Toxicol. Appl. Pharmacol. 242, 9-17.Google ScholarPubMed
Rouas, C. et al. (2010) Distribution of Soluble Uranium in the Nuclear Cell Compartment at Subtoxic Concentrations, Chem. Res. Toxicol. 23, 1883-1889.Google ScholarPubMed
Rouas, C. et al. (2011) Effect of nephrotoxic treatment with gentamicin on rats chronically exposed to uranium, Toxicology 279, 27-35.Google Scholar
Sanchez, D.J. et al. (2001) Nephrotoxicity of simultaneous exposure to mercury and uranium in comparison to individual effects of these metals in rats, Biol. Trace Elem. Res. 84, 139-154.Google ScholarPubMed
Schwartz, J.H. et al. (1976) Uranyl nitrate and HgCl2-induced alterations in ion transport, Kidney Int. Suppl. 6, S123-127.Google Scholar
Squibb, K.S. et al. (2006) Depleted uranium exposure and health effects in Gulf War veterans, Philos. Trans. R. Soc. Lond. B Biol. Sci. 361, 639-648.Google Scholar
Stokinger H.E. et al. (1953) Toxicity following inhalation for 1 and 2 years, The Pharmacology and Toxicology of Uranium Compounds. Division VI, Vol. I, (C. Voegtlin and H.C. Hodge, Eds), McGraw Hill, New York, NY, pp. 309-376.
Sztajnkrycer, M.D. et al. (2004) Chemical and radiological toxicity of depleted uranium, Mil. Med. 169, 212-216.Google ScholarPubMed
Taulan, M. et al. (2006) Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure, BMC Genomics 7, 2.Google ScholarPubMed
Taulan, M. et al. (2004) Renal toxicogenomic response to chronic uranyl nitrate insult in mice, Environ. Health Perspect. 112, 1628-1635.Google Scholar
Taylor, D.M. et al. (1997) Environmental uranium and human health, Rev. Environ. Health 12, 147-157.Google ScholarPubMed
Tessier, C. et al. (2012) Uranium microdistribution in renal cortex of rats after chronic exposure: a study by secondary ion mass spectrometry microscopy, Microsc. Microanal. 18, 123-133.Google ScholarPubMed
Thiebault, C. et al. (2007) Uranium induces apoptosis and is genotoxic to normal rat kidney (NRK-52E) proximal cells, Toxicol. Sci. 98, 479-487.Google Scholar
Tissandie, E. et al. (2007) In vivo effects of chronic contamination with depleted uranium on vitamin D(3) metabolism in rat, Biochim. Biophys. Acta 1770, 266-272.Google ScholarPubMed
Vaidya, V.S. et al. (2009) A rapid urine test for early detection of kidney injury, Kidney Int. 76, 108-114.Google ScholarPubMed
Valko, M. et al. (2005) Metals, toxicity and oxidative stress, Curr. Med. Chem. 12, 1161-1208.Google ScholarPubMed
Vicente-Vicente, L. et al. (2010) Nephrotoxicity of uranium: pathophysiological, diagnostic and therapeutic perspectives, Toxicol. Sci. 118, 324-347.Google ScholarPubMed
Voegtlin C. et al. (1953) Pharmacology and Toxicology of uranium compounds, Vol. 3-4, McGraw-Hill, New York.
WHO (2011) Guidelines for drinking-water quality, fourth edition.
Wrenn, M.E. et al. (1985) Metabolism of ingested U and Ra, Health Phys. 48, 601-633.Google ScholarPubMed
Zhu, G. et al. (2009) Renal dysfunction induced by long-term exposure to depleted uranium in rats, Arch. Toxicol. 83 (1), 37-46. Google ScholarPubMed
Zimmerman, K.L. et al. (2007) Temporal clinical chemistry and microscopic renal effects following acute uranyl acetate exposure, Toxicol. Pathol. 35, 1000-1009.Google ScholarPubMed