One nice thing about the title of this symposium is the ease of finding a one-word answer. A disadvantage, however, is that “science” is ambiguous: is “philosophy of mathematics” included in “philosophy of science” or not? If so, the one-word answer is obviously obvious; but if not, the same answer is still pretty obvious, or so I hope it will appear by the end of this symposium. In fact, I believe that recent work in foundations of mathematics, especially of the sort represented in this symposium, serves to sharpen considerably central debates in both philosophy of mathematics and philosophy of science generally, especially on the question of realism (vs. instrumentalism, or varieties of constructivism, or nominalism), and on the question of the indispensability of highly theoretical concepts and axioms for the more observational portions of mathematics and science.