Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-25T18:43:57.418Z Has data issue: false hasContentIssue false
  • English
  • Français

Endocytosis and exocytosis processes of gold nanoparticle with erythrocyte ghosts

Published online by Cambridge University Press:  06 July 2020

Víctor Gómez Flores
Víctor Gómez Flores*
Affiliation:
Institute of engineering and Technology University Autonomous of Ciudad Juarez, Ave. Del Charro #610.Col Partido Romero, Ciudad Juárez, México ZIP 32310
Get access

Abstract

The interaction of spherical gold nanoparticles (AuNPs) of 20nm elaborated by Turkevich method with the erythrocytes ghosts (7-8 μm) cell membrane was evaluated. The AuNPs-Membrane interaction was determined using confocal microscope, Uv-Vis spectroscopy and SEM analysis. The result show that nanoparticles larger than 20nm are adhered to the erythrocyte ghost membrane due their size and surface modification. Smaller AuNPs enter onto the cell by simple diffusion through the plasmatic membrane voids, these data may favor the best design and application in the treatments applied in biomedicine.

Type
Articles
Information
MRS Advances , Volume 5 , Issue 42: Nanoscale and Quantum Materials , 2020 , pp. 2169 - 2172
Check for updates
Copyright
Copyright © Materials Research Society 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Oh, N. and Park, J. H., “Surface chemistry of gold nanoparticles mediates their exocytosis in macrophages,” ACS Nano, vol. 8, no. 6, pp. 6232–6241, 2014, doi: 10.1021/nn501668a.CrossRefGoogle ScholarPubMed
Jang, H. S., “The diverse range of possible cell membrane interactions with substrates: Drug delivery, interfaces and mobility,” Molecules, vol. 22, no. 12, pp. 26–28, 2017, doi: 10.3390/molecules22122197.CrossRefGoogle ScholarPubMed
Wang, B., Zhang, L., Sung, C. B., and Granick, S., “Nanoparticle-induced surface reconstruction of phospholipid membranes,” Proc. Natl. Acad. Sci. U. S. A., vol. 105, no. 47, pp. 18171–18175, 2008, doi: 10.1073/pnas.0807296105.CrossRefGoogle ScholarPubMed
Brenner, J. S. et al. , “Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude,” Nat. Commun., vol. 9, no. 1, 2018, doi: 10.1038/s41467-018-05079-7.CrossRefGoogle ScholarPubMed
Xing, S. et al. ., “Doxorubicin/gold nanoparticles coated with liposomes for chemo-photothermal synergetic antitumor therapy,” Nanotechnology, vol. 29, no. 40, 2018, doi: 10.1088/1361-6528/aad358.CrossRefGoogle ScholarPubMed
Turkevich, J., Stevenson, P. C., and Hillier, J., “A study of the nucleation and growth processes in the synthesis of colloidal gold,” Discuss. Faraday Soc., vol. 11, no. c, pp. 55–75, 1951, doi: 10.1039/DF9511100055.CrossRefGoogle Scholar
Niggli, V., Adunyah, E. S., Penniston, J. T., and Carafoli, E., “Purified (Ca2+-Mg2+)-ATPase of the erythrocyte membrane. Reconstitution and effect of calmodulin and phospholipids.,” J. Biol. Chem., vol. 256, no. 1, pp. 395–401, 1981.Google ScholarPubMed
Elfeky, S. A., “Synthesis and Spectral Characteristics of Gold Nanoparticle Labelled with Fluorescein Sodium.”Google Scholar
Govindaraju, S., Ankireddy, S. R., Viswanath, B., Kim, J., and Yun, K., “Fluorescent Gold Nanoclusters for Selective Detection of Dopamine in Cerebrospinal fluid,” Sci. Rep., vol. 7, pp. 1–12, 2017, doi: 10.1038/srep40298.CrossRefGoogle ScholarPubMed