Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-16T13:22:06.917Z Has data issue: false hasContentIssue false
  • English
  • Français

Una posible asociación entre el gen del receptor A de la CCK-RA y las alucinaciones auditivas persistentes en la esquizofrenia

Published online by Cambridge University Press:  12 May 2020

J. Sanjuán ,
I. Toirac ,
J. C. González ,
C. Leal ,
M. D. Moltó ,
C. Nájera  and
R. de Frutos
J. Sanjuán
Affiliation:
Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Blasco lbáñez 15, Universitat de Valencia, 46010Valencia, España
I. Toirac
Affiliation:
Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, España
J. C. González
Affiliation:
Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Blasco lbáñez 15, Universitat de Valencia, 46010Valencia, España
C. Leal
Affiliation:
Unidad de Psiquiatría, Facultad de Medicina, Hospital Clínico, Blasco lbáñez 15, Universitat de Valencia, 46010Valencia, España
M. D. Moltó
Affiliation:
Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, España
C. Nájera
Affiliation:
Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, España
R. de Frutos
Affiliation:
Departamento de Genética, Facultad de Biología, Universitat de Valencia, 46100 Burjasot, Valencia, España
Get access

Resumen

Estudios recientes han propuesto que variaciones del ADN en el gen del receptor A de la pancreocimina (CCK-RA) podrían predisponer a los individuos a la esquizofrenia y particularmente a las alucinaciones auditivas’ (AA). El propósito de este estudio es evaluar la asociación entre las AA, utilizando una escala específica para ellas en la esquizofrenia (PSYRATS), y el polimorfismo del RA-CCK en 779 en una muestra española. Se estudió un total de 105 pacientes esquizofrénicos del DSM-IV con AA y 93 controles no relacionados. Se consideró que 22 pacientes tenían alucinaciones auditivas persistentes, y mostraban características clínicas y demográficas similares a los pacientes con AA episódicas, con la excepción de los valores de la PSYRATS. El grupo de AA persistentes mostró una mayor cantidad de alelo Al cuando se comparó con los grupos de alucinaciones episódicas o de control. Nuestros datos apoyan el posible papel del gen del RA-CCK en el desarrollo de AA persistentes en los pacientes esquizofrénicos.

Keywords

EsquizofreniaAlucinaciones auditivasReceptor A de la colecistokininaAlucinaciones persistentesAnálisis de asociación
Type
Artículos Originales
Information
European Psychiatry (Ed. Española) , Volume 12 , Issue 2 , March 2005 , pp. 94 - 98
Copyright
Copyright © European Psychiatric Association 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

SanjuanJ, ToiracI, GonzálezJC, LealC, MoltóMD, NájeraC, de FrutosR. Una posible asociación entre el gen del receptor A de la CCK-RA y las alucinaciones auditivas persistentes en la esquizofrenia. Eur Psychiatry2004;19:349–353.

References

Bibliografía

Andreasen, NC, Flaum, M. Schizophrenia: the characteristic symptoms. Schizophr Bull 1991; 17: 27–49.CrossRefGoogle ScholarPubMed
Bachus, SE, Hyde, TM, Herman, MM, Egan, MF, Kleinman, JE. Abnormal cholecystokinin mRNA levels in entorhinal cortex of schizophrenics. J Psychiatr Res 1997; 31: 233-56.CrossRefGoogle ScholarPubMed
Beinfeld, MC. An introduction to neuronal cholecystokinin. Peptides 2001; 8: 1197–2000.CrossRefGoogle Scholar
Cheung, P, Schweitzer, I, Crowley, K, Tuckwell, V. Violence in schizophrenia: role of hallucinations and delusions. Schizophr Res 1997; 26: 81–90.CrossRefGoogle ScholarPubMed
Conley, RR, Buchanan, RW. Evaluation of treatment-resistant schizophrenia. Schizophr Bull 1997; 23: 663-74.CrossRefGoogle ScholarPubMed
David, AS. Auditory hallucinations: phenomenology, neuropsychology and neuroimaging update. Acta Psychiatr Scand 1999: 395: 95104.Google ScholarPubMed
Falloon, IR, Talbot, RE. Persistent auditory hallucinations: coping mechanisms and implications for management. Psychol Med 1981; 11: 329-39.CrossRefGoogle ScholarPubMed
Farmery, SM, Owen, F, Poulter, M, Crow, TJ. Reduced high affinity cholecystokinin binding in hippocampus and frontal cortex of schizophrenic patients. Life Sci 1985; 36: 473-7.CrossRefGoogle ScholarPubMed
Feifel, D, Reza, T, Robeck, S. Antipsychotic potential of CCK-based treatments: an assessment using the prepfllse inhibition model of psychosis. Neuropsychopharmacology 1999; 20: 141-9.CrossRefGoogle Scholar
Ferrier, IN, Crow, TJ, Farmery, SM, Roberts, GW, Owen, F, Adrian, TE, Bloom, SR. Reduced cholecystokinin levels in the limbic lobe inschizophrenia. A marker for pathology underlying the defect State? Ann NYA cad Sci 1985; 448: 4995–5011.Google Scholar
Funakoshi, A, Miyasaka, K, Matsumoto, H, Yamamori, S, Takigucji, S, Kataoka, Y, Matsusue, K, Kono, A, Shimokata, H. Gene structure of human cholecystokinin (CCK) type A receptor: body fat content is related to CCK type-A receptor gene promoter polymorphism. FEBS Lett 2000; 466: 264-6.CrossRefGoogle ScholarPubMed
Garver, DL, Holcomb, JA, Christensen, JD. Heterogeneity of response to antipsychotics from multiple disorders in the schizophrenia spectrum. J Clin Psychiatry 2000; 61: 964-72.CrossRefGoogle ScholarPubMed
Haddock, G, McCarron, J, Tarrier, N, Faragher, EB. Scales to measure dimensions of hallucinations and delusions: the psychotic symptom rating scales (PSYRATS). Psychol Med 1999; 29: 879-88.CrossRefGoogle Scholar
Inoue, H, lanuoti, CA, Welling, CM, Veile, R, Donis-Keller, H, Permutt, MA. Human cholecystokinin type A receptor gene: cytogenetic localization, physical mapping, and identification of two missense variants in patients with obesity and non-insulin-dependent diabetes mellitus (NIDDM). Genomics 1997; 42: 331-5.CrossRefGoogle Scholar
Ise, K, Akiyoshi, J, Horinuchi, Y, Tsutsumi, T, Isogawa, K, Nagayama, H. Association between the CCK-A receptor gene and panic disorder. Am J Med Genet 2003; 118: 29–31.CrossRefGoogle Scholar
Jenner, JA, Van de Willige G, Wiersma D. Effectiveness of cognitive therapy with coping training for persistent auditory hallucinations: a retrospective study of attenders of a psychiatric out-patient department. Acta Psychiatr Scand 1998; 98: 384-9.CrossRefGoogle ScholarPubMed
Kane, JM, Honigfeld, G, Singer, J, Meltzer, H. Clozapine in treatment resistant schizophrenics. Psychopharmacol Bull 1988; 24: 62-7.Google ScholarPubMed
Kennedy, JL, Bradwejn, J, Koszycki, D, King, N, Crowe, R, Vincent, J, et al. Investigation of cholecystokinin System genes in panic disorder. Mol Psychiatry 1999; 4: 284-5.CrossRefGoogle ScholarPubMed
Kerwin, R, Robinson, P, Stephenson, J. Distribution of CCK binding sites in the human hippocampal formation and their alteration in schizophrenia: a post-mortem auto radiographic study. Psychol Med 1992; 22: 37–43.Google Scholar
Lawrie, SM, Buechel, C, Whalley, HC, Frith, CD, Friston, KJ, Johnstone, EC. Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations. Biol Psychiatry 2002; 51: 1008-111.CrossRefGoogle ScholarPubMed
Lesch, KP. Hallucinations: psychopathology mects functional genomies. Mol Psychiatry 1998; 3: 278-81.CrossRefGoogle Scholar
Morrison, AP, Wells, A, Nothard, S. Cognitive factors in predisposition to auditory and visual hallucinations. Br J Clin Psychol 2000: 39: 6778.Google Scholar
Nair, NP, Lal, S, Thavundayil, JX, Wood, PL, Etienne, P, Guyda, H. CCK-33 antagonizes apomorphine-induced growth hormone secretion and increases basal prolactin levels in man. Neuropeptides 1984; 4: 281-91.CrossRefGoogle ScholarPubMed
Okubo, T, Harada, S. Polymorphisms of the CCK, CCKAR and CCKBR genes: an association with alcoholism study. J Stud Alcohol 2001; 62: 413-21.CrossRefGoogle ScholarPubMed
Okubo, T, Harada, S, Higuchi, S, Matsushita, S. Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholism. Alcohol Clin Exp Res 2002; 26(Suppl):2S–5S.CrossRefGoogle ScholarPubMed
Peselow, E, Angrist, B, Sudilovsky, A, Corwin, J, Siekierski, J, Trent, F, et al. Double blind controlled triáis of cholecystokininoctapeptide in neuroleptic-refractory schizophrenia. Psychopharmacology 1987; 91: 80-4.CrossRefGoogle Scholar
Shergill, SS, Murray, RM, McGuire, PK. Auditory hallucinations:: a review of psychological treatments. Schizophr Res 1998; 32: 137-50.CrossRefGoogle ScholarPubMed
Slade, P, Bentall, R. Sensory Deception: A Scientific Analysis of Hallucinations. London: Croom Helm; 1988.Google Scholar
Stephane, M, Barton, S, Boutros, NN. Auditory verbal hallucinations and dysfunction of the neural substrates of speech. Schizophr Res 2001; 50: 61–78.CrossRefGoogle Scholar
Tachikawa, H, Harada, S, Kawanishi, Y, Okubo, T, Shiraishi, H. Novel polymorphisms of the human cholecystokinin A receptor gene: An association analysis with schizophrenia. Am J Med Genet 2000; 96: 141-5.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
Tachikawa, H, Harada, S, Kawanishi, Y, Okubo, T, Suzuki, T. Linked polymorphisms (-333G > T and -286 A > G) in the promoter región of the CCK-receptor gene may be associated with schizophrenia. Psychiatry Res 2001; 103: 147-55.CrossRefGoogle Scholar
Vaccarino, FJ. Nucleus accumbens dopamine-CCK interactions in psychostimulant reward and related behaviours. Neurosci Biobehav Rev 1994; 18: 207-14. ,CrossRefGoogle Scholar
Vanakoski, J, Virkkunen, M, Naukkannen, H, Goldman, D. No association of CCK and CCK (B) receptor polymorphisms with alcohol dependence. Psychiatry Res 2001; 102: 1–7.CrossRefGoogle ScholarPubMed
Wei, J, Hemmings, GP. The CCK-A receptor gene possibly associated with auditory hallucinations in schizophrenia. Eur Psychiatry 1999; 14: 67–70.CrossRefGoogle Scholar
Weiss, AP, Heckers, S. Neuroimaging of hallucinations: a review ol the literature. Psychiatry Res 1999; 92: 61–74.CrossRefGoogle Scholar
Zachrisson, O, de Belleroche, J, Wendt, KR, Hirsch, S, Lindefors, N. Cholecystokinin CCK(B) receptor mRNA isoforms: expression in schizophrenic brains. Neuroreport 1999; 10: 3265-8.CrossRefGoogle ScholarPubMed
Zhang, XY, Zhou, DF, Zhang, PY, Wei, J. The CCK-A receptor gene possibly associated with positive symptoms of schizophrenia. Mol Psychiatry 2000; 5: 239-40.CrossRefGoogle ScholarPubMed