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Abbreviations: CGA, chlorogenic acid; CME, Cichorium intybus methanolic extract; DMEM, Dulbecco's modified Eagle's medium; G6P, glucose-6-phosphatase; GSK, glycogen synthase kinase; HFD, high-fat diet; IR, insulin receptor; IRS, IR substrate; PI3K, phosphatidylinositol 3-kinase; Akt/PKB, protein kinase B; PC, plasma cholesterol; PG, plasma glucose; PT, plasma TAG; PTP1B, protein tyrosine phosphatase 1B; STZ, streptozotocin