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Beneficial effect of Toona sinensis Roemor on improving cognitive performance and brain degeneration in senescence-accelerated mice

Published online by Cambridge University Press:  08 March 2007

Jiunn-Wang Liao ,
Cheng-Kuang Hsu ,
Ming-Fu Wang ,
Wen-Min Hsu  and
Yin-Ching Chan
Jiunn-Wang Liao
Affiliation:
Graduate Institute of Veterinary Pathology, National Chung Hsing University, Taichung, Taiwan, Republic of China
Cheng-Kuang Hsu
Affiliation:
Asia University, Asia University, Wufung, Taichung County, Taiwan, Republic of China
Ming-Fu Wang
Affiliation:
Department of Food and Nutrition, Providence University, Taiwan, Republic of China
Wen-Min Hsu
Affiliation:
Department of Food and Nutrition, Providence University, Taiwan, Republic of China
Yin-Ching Chan*
Affiliation:
Department of Food and Nutrition, Providence University, Taiwan, Republic of China
*
*Corresponding author: Dr Y.-C. Chan, fax +86 4 26530027, email [email protected]
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Abstract

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The purpose of the present study was to examine the effects of Toona sinensis Roemor extracts on antioxidative activities, brain morphological changes and cognitive ability. In an in vitro study, the antioxidant capacities of water extracts from Toona sinensis Roemor leaf (TSL), root (TSR) and bark (TSB) were evaluated by an α,α-diphenyl-β-pricryl-hydrazyl radical-scavenging test. The results showed that the scavenging activities of all Toona sinensis Roemor extracts were over 80% at a concentration of 0·625mg/ml. In an in vivo study, 3-month-old male senescence-accelerated-prone 8 mice were used as the tested subjects and fed four different diets: casein diet or casein diet supplemented with 1% TSL, TSR or TSB extract for 12 weeks. The results showed that the mice supplemented with Toona sinensis Roemor extracts demonstrated significantly less amyloid β-protein deposition and lower levels of thiobarbituric acid-reactive substances than the control group. All Toona sinensis Roemor diet groups also showed better active shuttle avoidance responses, and higher superoxide dismutase, catalase and glutathione peroxidase activities, than the control group. It can thus be concluded that supplementation with either TSL, TSR or TSB extract could not only reduce the incidence of ß-amyloid plaques, but also improve learning and memory ability in senescence-accelerated-prone 8 mice. This might be due to the beneficial effects of Toona sinensis Roemor extracts on promoting the antioxidative defence system.

Keywords

Toona sinensis RoemorCognitive abilityAmyloid β-protein depositionAntioxidative system
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 2 , August 2006 , pp. 400 - 407
Copyright
Copyright © The Nutrition Society 2006

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