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The cognitive-emotional brain: Opportunitvnies and challenges for understanding neuropsychiatric disorders

Published online by Cambridge University Press:  08 June 2015

Alexander J. Shackman ,
Andrew S. Fox  and
David A. Seminowicz
Alexander J. Shackman
Affiliation:
Department of Psychology; Affective & Translational Neuroscience Laboratory; Neuroscience & Cognitive Science Program; Maryland Neuroimaging Center; University of Maryland, College Park, MD 20742. [email protected]://shackmanlab.org
Andrew S. Fox
Affiliation:
Departments of Psychology and Psychiatry; HealthEmotions Research Institute; Wisconsin Psychiatric Institute & Clinics; University of Wisconsin–Madison; Madison, WI 53719. [email protected]://brainimaging.waisman.wisc.edu/~fox/
David A. Seminowicz
Affiliation:
Department of Neural and Pain Sciences; School of Dentistry; University of Maryland, Baltimore, MD 21201. [email protected]://www.dental.umaryland.edu/neuralpain/clinical-and-translational-research/dr-seminowicz/
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Abstract

Many of the most common neuropsychiatric disorders are marked by prominent disturbances of cognition and emotion. Characterizing the complex neural circuitry underlying the interplay of cognition and emotion is critically important, not just for clarifying the nature of the mind, but also for discovering the root causes of a broad spectrum of debilitating neuropsychiatric disorders, including anxiety, schizophrenia, and chronic pain.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 38 , 2015 , e86
Copyright
Copyright © Cambridge University Press 2015 

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References

Adachi, Y., Osada, T., Sporns, O., Watanabe, T., Matsui, T., Miyamoto, K. & Miyashita, Y. (2012) Functional connectivity between anatomically unconnected areas is shaped by collective network-level effects in the macaque cortex. Cerebral Cortex 22(7):1586–92. doi: 10.1093/cercor/bhr234.CrossRefGoogle ScholarPubMed
Akam, T. & Kullmann, D. M. (2014) Oscillatory multiplexing of population codes for selective communication in the mammalian brain. Nature Reviews Neuroscience 15:111–22. doi: 10.1038/nrn3668.CrossRefGoogle ScholarPubMed
Barrett, L. F. & Satpute, A. B. (2013) Large-scale brain networks in affective and social neuroscience: Towards an integrative functional architecture of the brain. Current Opinion in Neurobiology 23(3):361–72. doi: 10.1016/j.conb.2012.12.012.CrossRefGoogle ScholarPubMed
Birn, R. M., Shackman, A. J., Oler, J. A., Williams, L. E., McFarlin, D. R., Rogers, G. M., Shelton, S. E., Alexander, A. L., Pine, D. S., Slattery, M. J., Davidson, R. J., Fox, A. S. & Kalin, N. H. (2014) Evolutionarily-conserved dysfunction of prefrontal-amygdalar connectivity in early-life anxiety. Molecular Psychiatry 19:915–22.CrossRefGoogle ScholarPubMed
Borsook, D., Becerra, L. & Hargreaves, R. (2006) A role for fMRI in optimizing CNS drug development. Nature Reviews Drug Discovery 5(5):411–24. doi: 10.1038/nrd2027.CrossRefGoogle ScholarPubMed
Buhle, J.T., Silvers, J. A., Wager, T. D., Lopez, R., Onyemekwu, C., Kober, H., Weber, J., Ochsner, K. N. (2014) Cognitive reappraisal of emotion: A meta-analysis of human neuroimaging studies. Cerebral Cortex 24: 2981–90. doi: bht154 [pii] 10.1093/cercor/bht154.CrossRefGoogle ScholarPubMed
Bullmore, E. & Sporns, O. (2012) The economy of brain network organization. Nature Reviews Neuroscience 13(5):336–49. doi: 10.1038/nrn3214.CrossRefGoogle ScholarPubMed
Bystritsky, A. (2006) Treatment-resistant anxiety disorders. Molecular Psychiatry 11:805–14. doi: 4001852 [pii]10.1038/sj.mp.4001852.CrossRefGoogle ScholarPubMed
Cabral, J., Kringelbach, M. L. & Deco, G. (2014) Exploring the network dynamics underlying brain activity during rest. Progress in Neurobiology 114C:102–31. doi: 10.1016/j.pneurobio.2013.12.005.CrossRefGoogle Scholar
Casey, B. J., Craddock, N., Cuthbert, B. N., Hyman, S. E., Lee, F. S. & Ressler, K. J. (2013) DSM-5 and RDoC: Progress in psychiatry research? Nature Reviews Neuroscience 14(11):810–14. doi: 10.1038/nrn3621.CrossRefGoogle ScholarPubMed
Cavanagh, J. F., & Shackman, A. J. (2014) Frontal midline theta reflects anxiety and cognitive control: Meta-analytic evidence. Journal of Physiology, Paris. pii: S0928-4257(14)00014-X. doi: 10.1016/j.jphysparis.2014.04.003. [Epub ahead of print].Google ScholarPubMed
Chen, A. C., Oathes, D. J., Chang, C., Bradley, T., Zhou, Z. W., Williams, L. M., Glover, G. H., Deisseroth, K. & Etkin, A. (2013) Causal interactions between fronto-parietal central executive and default-mode networks in humans. Proceedings of the National Academy of Sciences of the United States of America 110(49):19944–49. doi: 10.1073/pnas.1311772110.CrossRefGoogle ScholarPubMed
Collins, P. Y., Patel, V., Joestl, S. S., March, D., Insel, T. R., Daar, A. S., Anderson, W., Dhansay, M. A., Phillips, A., Shurin, S., Walport, M., Ewart, W., Savill, S. J., Bordin, I. A., Costello, E. J., Durkin, M., Fairburn, C., Glass, R. I., Hall, W., Huang, Y., Hyman, S. E., Jamison, K., Kaaya, S., Kapur, S., Kleinman, A., Ogunniyi, A., Otero-Ojeda, A., Poo, M. M., Ravindranath, V., Sahakian, B. J., Saxena, S., Singer, P. A. & Stein, D. J. (2011) Grand challenges in global mental health. Nature 475:27–30. doi: 475027a [pii]10.1038/475027a.CrossRefGoogle ScholarPubMed
Damasio, A. (1994/2005) Descartes' error: Emotion, reason and the human brain. Penguin. (Original work published by Putnam in 1994).Google Scholar
de Sousa, R. (2014) Emotion. In: Stanford encyclopedia of philosophy, ed. Zalta, E. N.. Available at: http://plato.stanford.edu/entries/emotion/.Google Scholar
Dum, R. P., Levinthal, D. J. & Strick, P. L. (2009) The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. Journal of Neuroscience 29:14223–35. doi: 29/45/14223 [pii] 10.1523/JNEUROSCI.3398-09.2009.CrossRefGoogle ScholarPubMed
Duncan, S. & Barrett, L. F. (2007) Affect is a form of cognition: A neurobiological analysis. Cognition & Emotion 21:1184–211.CrossRefGoogle ScholarPubMed
Ekstrom, L. B., Roelfsema, P. R., Arsenault, J. T., Bonmassar, G. & Vanduffel, W. (2008) Bottom-up dependent gating of frontal signals in early visual cortex. Science 321:414–17.CrossRefGoogle ScholarPubMed
Fornito, A., Zalesky, A. & Breakspear, M. (2015) The connectomics of brain disorders. Nature Reviews Neuroscience 16:159–72.CrossRefGoogle ScholarPubMed
Fox, A. S. & Kalin, N. H. (2014) A translational neuroscience approach to understanding the development of social anxiety disorder and its pathophysiology. American Journal of Psychiatry 171:1162–73.CrossRefGoogle ScholarPubMed
Fox, A. S., Oakes, T. R., Shelton, S. E., Converse, A. K., Davidson, R. J. & Kalin, N. H. (2005) Calling for help is independently modulated by brain systems underlying goal-directed behavior and threat perception. Proceedings of the National Academy of Sciences of the United States of America 102:4176–79. doi: 0409470102 [pii] 10.1073/pnas.0409470102 [doi].CrossRefGoogle ScholarPubMed
Fox, A. S., Shelton, S. E., Oakes, T. R., Converse, A. K., Davidson, R. J. & Kalin, N. H. (2010) Orbitofrontal cortex lesions alter anxiety-related activity in the primate bed nucleus of stria terminalis. Journal of Neuroscience 30:7023–27.CrossRefGoogle ScholarPubMed
Goldberg, D. S. & McGee, S. J. (2011) Pain as a global public health priority. BMC Public Health 11:770. doi: 10.1186/1471-2458-11-770.CrossRefGoogle Scholar
Goldman-Rakic, P. S. (1988) Topography of cognition: Parallel distributed networks in primate association cortex. Annual Review of Neuroscience 11:137–56. doi: 10.1146/annurev.ne.11.030188.001033.CrossRefGoogle ScholarPubMed
Gratton, C., Nomura, E. M., Perez, F. & D'Esposito, M. (2012) Focal brain lesions to critical locations cause widespread disruption of the modular organization of the brain. Journal of Cognitive Neuroscience 24(6):1275–85. doi: 10.1162/jocn_a_00222.CrossRefGoogle ScholarPubMed
Grupe, D. W. & Nitschke, J. B. (2013) Uncertainty and anticipation in anxiety: An integrated neurobiological and psychological perspective. Nature Reviews. Neuroscience 14:488–501. doi: nrn3524 [pii]10.1038/nrn3524.CrossRefGoogle ScholarPubMed
Guller, Y., Ferrarelli, F., Shackman, A. J., Sarasso, S., Peterson, M. J., Langheim, F. J., Meyerand, M. E., Tononi, G. & Postle, B. R. (2012) Probing thalamic integrity in schizophrenia using concurrent transcranial magnetic stimulation and functional magnetic resonance imaging. Archives of General Psychiatry 69(7):662–71. doi: 10.1001/archgenpsychiatry.2012.23.CrossRefGoogle ScholarPubMed
Honey, C. J., Sporns, O., Cammoun, L., Gigandet, X., Thiran, J. P., Meuli, R. & Hagmann, P. (2009) Predicting human resting-state functional connectivity from structural connectivity. Proceedings of the National Academy of Sciences of the United States of America 106(6):2035–40. doi: 10.1073/pnas.0811168106.CrossRefGoogle ScholarPubMed
Iannetti, G. D., Salomons, T. V., Moayedi, M., Mouraux, A. & Davis, K. D. (2013) Beyond metaphor: Contrasting mechanisms of social and physical pain. Trends in Cognitive Sciences 17:371–78.CrossRefGoogle ScholarPubMed
IOM (Institute of Medicine) (2011) Relieving pain in America: A blueprint for transforming prevention, care, education, and research. National Academies Press. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22553896 Google Scholar
Karnath, H.-O. & Smith, D. V. (2014) The next step in modern brain lesion analysis: Multivariate pattern analysis. Brain 137:2405–406.CrossRefGoogle ScholarPubMed
Kessler, R. C., Petukhova, M., Sampson, N. A., Zaslavsky, A. M. & Wittchen, H. U. (2012) Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States. International Journal of Methods in Psychiatric Research 21:169–84. doi: 10.1002/mpr.1359.CrossRefGoogle ScholarPubMed
LeDoux, J. E. (1995) Emotion: Clues from the brain. Annual Review of Psychology 46:209–35. doi: 10.1146/annurev.ps.46.020195.001233.CrossRefGoogle ScholarPubMed
LeDoux, J. E. (2012) Rethinking the emotional brain. Neuron 73(4):653–76. doi: 10.1016/j.neuron.2012.02.004.CrossRefGoogle ScholarPubMed
Lindquist, K. A. & Barrett, L. F. (2012) A functional architecture of the human brain: Emerging insights from the science of emotion. Trends in Cognitive Sciences 16(11):533–40.CrossRefGoogle ScholarPubMed
Logothetis, N. K. (2008) What we can do and what we cannot do with fMRI. Nature 453:869–78. doi: nature06976 [pii]10.1038/nature06976.CrossRefGoogle Scholar
Mesulam, M. M. (1998) From sensation to cognition. Brain 121(Pt 6):1013–52.CrossRefGoogle ScholarPubMed
Millan, M. J., Agid, Y., Brune, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., Connor, R., Davis, S., Deakin, B., DeRubeis, R. J., Dubois, B., Geyer, M. A., Goodwin, G. M., Gorwood, P., Jay, T. M., Joëls, M., Mansuy, I. M., Meyer-Lindenberg, A., Murphy, D., Rolls, E., Saletu, B., Spedding, M., Sweeney, J., Whittington, M. & Young, L. J. (2012) Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nature Reviews Drug Discovery 11(2):141–68. doi: 10.1038/nrd3628.CrossRefGoogle ScholarPubMed
Narayanan, N. S., Cavanagh, J. F., Frank, M. J. & Laubach, M. (2013) Common medial frontal mechanisms of adaptive control in humans and rodents. Nature Neuroscience 16(12):1888–95. doi: 10.1038/nn.3549.CrossRefGoogle ScholarPubMed
Okon-Singer, H., Hendler, T., Pessoa, L. & Shackman, A. J. (2015) The neurobiology of emotion-cognition interactions: Fundamental questions and strategies for future research. Frontiers in Human Neuroscience 9: 58.CrossRefGoogle ScholarPubMed
Oler, J. A., Birn, R. M., Patriat, R., Fox, A. S., Shelton, S. E., Burghy, C. A., Stodola, D. E., Essex, M. J., Davidson, R. J. & Kalin, N. H. (2012) Evidence for coordinated functional activity within the extended amygdala of non-human and human primates. NeuroImage 61:1059–66. doi: S1053-8119(12)00326-6 [pii]10.1016/j.neuroimage.2012.03.045.CrossRefGoogle ScholarPubMed
Paulus, M. P., Feinstein, J. S., Castillo, G., Simmons, A. N. & Stein, M. B. (2005) Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processing. Archives of General Psychiatry 62(3):282–88. doi: 62/3/282 [pii]10.1001/archpsyc.62.3.282.CrossRefGoogle ScholarPubMed
Pearson, J. M., Watson, K. K. & Platt, M. L. (2014) Decision making: The neuroethological turn. Neuron 82(5):950–65. doi: 10.1016/j.neuron.2014.04.037.CrossRefGoogle ScholarPubMed
Pessoa, L. (2013) The cognitive-emotional brain. From interactions to integration. MIT Press.CrossRefGoogle Scholar
Reinhart, R. M. & Woodman, G. F. (2014) Causal control of medial-frontal cortex governs electrophysiological and behavioral indices of performance monitoring and learning. Journal of Neuroscience 34(12):4214–27. doi: 10.1523/JNEUROSCI.5421-13.2014.CrossRefGoogle ScholarPubMed
Roseboom, P. H., Nanda, S. A., Fox, A. S., Oler, J. A., Shackman, A. J., Shelton, S. E., Davidson, R. J. & Kalin, N. H. (2014) Neuropeptide Y receptor gene expression in the primate amygdala predicts anxious temperament and brain metabolism. Biological Psychiatry 76: 850–57.CrossRefGoogle ScholarPubMed
Schmitter, A. M. (2014) 17th and 18th century theories of emotions. In: Stanford encyclopedia of philosophy, ed. Zalta, E. N.. Available at: http://plato.stanford.edu/entries/emotions-17th18th/.Google Scholar
Seminowicz, D. A., Mayberg, H. S., McIntosh, A. R., Goldapple, K., Kennedy, S., Segal, Z. & Rafi-Tari, S. (2004) Limbic-frontal circuitry in major depression: A path modeling metanalysis. NeuroImage 22:409–18. doi: 10.1016/j.neuroimage.2004.01.015 S1053811904000497 [pii].CrossRefGoogle ScholarPubMed
Shackman, A. J., Fox, A. S., Oler, J. A., Shelton, S. E., Davidson, R. J. & Kalin, N. H. (2013) Neural mechanisms underlying heterogeneity in the presentation of anxious temperament. Proceedings of the National Academy of Sciences of the United States of America 110:6145–50. doi: 1214364110 [pii] 10.1073/pnas.1214364110.CrossRefGoogle ScholarPubMed
Shackman, A. J., McMenamin, B. W., Maxwell, J. S., Greischar, L. L. & Davidson, R. J. (2009) Right dorsolateral prefrontal cortical activity and behavioral inhibition. Psychological Science 20:1500–506.CrossRefGoogle ScholarPubMed
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J. & Davidson, R. J. (2011) The integration of negative affect, pain and cognitive control in the cingulate cortex. Nature Reviews Neuroscience 12(3):154–67. Available at: http://www.ncbi.nlm.nih.gov/pubmed/21331082.CrossRefGoogle ScholarPubMed
Stout, D. M., Shackman, A. J. & Larson, C. L. (2013) Failure to filter: Anxious individuals show inefficient gating of threat from working memory. Frontiers in Human Neuroscience 7:58.CrossRefGoogle ScholarPubMed
Turk-Browne, N. B. (2013) Functional interactions as big data in the human brain. Science 342:580–84.CrossRefGoogle ScholarPubMed
Uhlhaas, P. J. & Singer, W. (2012) Neuronal dynamics and neuropsychiatric disorders: Toward a translational paradigm for dysfunctional large-scale networks. Neuron 75(6):963–80. doi: 10.1016/j.neuron.2012.09.004.CrossRefGoogle Scholar
Vincent, J. L., Patel, G. H., Fox, M. D., Snyder, A. Z., Baker, J. T., Van Essen, D. C., Zempel, J. M., Snyder, L. H., Corbetta, M. & Raichle, M. E. (2007) Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447:83–86. doi: nature05758 [pii]10.1038/nature05758.CrossRefGoogle ScholarPubMed
Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., Burstein, R., Murray, C. J. & Vos, T. (2013) Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet 382(9904):1575–86. doi: 10.1016/S0140-6736(13)61611-6.CrossRefGoogle ScholarPubMed
Woo, C. W., Koban, L., Kross, E., Lindquist, M. A., Banich, M. T., Ruzic, L., Andrews-Hanna, J. R. & Wager, T. D. (2014) Separate neural representations for physical pain and social rejection. Nature Communications 5:5380.CrossRefGoogle ScholarPubMed