In the excavation of Pendejo Cave (FB 9366) near Orogrande, New Mexico, 16 friction skin imprints were found in five stratified zones on clay nodules, baked at over 120°C. After careful analysis, expert dermatoglyphologists determined that these imprints had positive primate characteristics. The imprints are probably of human origin, since no other primates are known to have existed in prehistoric New Mexico. Eight of the imprints occurred in three well-dated zones falling in the late Pleistocene. These zones have direct radiocarbon dates between 12,000 and 37,000 B.P. In addition to their association with radiocarbon determinations, the prints come from three of 24 stratified zones, intensively studied by geologists and pedologists, that are dated in sequence by 34 other radiocarbon determinations acquired from four different laboratories. The imprints are associated with a column of over 35,000 paleontological specimens and more than 15,000 botanical remains. These specimens indicate Pleistocene changes and supply evidence of human transportation and modification of various materials. The prints are also associated with artifacts, ecofacts, features of human construction, and human remains. The imprint specimens therefore provide evidence of Pleistocene human occupation in the New World.