Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-26T02:50:48.888Z Has data issue: false hasContentIssue false

Chapter 10 - Depression

Published online by Cambridge University Press:  21 June 2019

By
Chanaka Wijeratne
Edited by
Rob Butler  and
Cornelius Katona
Rob Butler
Affiliation:
Waitemata DHB and North Shore Hospital, Auckland
Cornelius Katona
Affiliation:
Helen Bamber Foundation
Get access

Summary

Late-life depression is a complex disorder that results from the interplay between stressful events, personality vulnerability and physical illness. It is associated with significant distress and disability, and is a risk factor for suicide and dementia.

Type
Chapter
Information
Seminars in Old Age Psychiatry , pp. 112 - 122
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ismail, Z., Fischer, C., McCall, W. V. (2013) ‘What characterizes late-life depression?’ Psychiatr Clin N Am 36: 483–96.Google Scholar
Trollor, J., Anderson, T., Sachdev, P., et al. (2007) ‘Prevalence of mental disorders in the elderly: The Australian national mental health and well-being survey’. Am J Geriatr Psychiatry 15: 455–66.CrossRefGoogle ScholarPubMed
Henderson, A. (1994) ‘Does ageing protect against depression?’ Soc Psych Psychiatric Epidemiology 29: 107–9.Google Scholar
Kessler, R., Berglund, P., Demler, O., et al. (2005) ‘Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication’. Arch Gen Psychiatry 62: 593–602.Google Scholar
Pickett, Y. R., Bazelais, K. N., Bruce, M. L. (2013) ‘Late-life depression in older African Americans: A comprehensive review of epidemiological and clinical data’. Int J Geriatr Psychiatry 28: 903–13.CrossRefGoogle ScholarPubMed
Hegeman, J. M., Kok, R. M., van der Mast, R. C., Giltay, E. J. (2012) ‘Phenomenology of depression in older compared with younger adults: Meta-analysis’. Br J Psychiatry 200: 275–81.CrossRefGoogle ScholarPubMed
Veltman, E. M., Lamers, F., Comijs, H. C., et al. (2017) ‘Depressive subtypes in an elderly cohort identified using latent class analysis’. J Affect Disord 218: 123–30.Google Scholar
Parker, G., Fink, M., Shorter, E., et al. (2010) ‘Issues for DSM-5: Whither melancholia? The case for its classification as a distinct mood disorder’. Am J Psychiatry 167: 745–7.Google Scholar
O’Brien, J., Lloyd, A., McKeith, I., et al. (2004) ‘A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects’. Am J Psychiatry 161: 2081–90.Google ScholarPubMed
Riddle, M., Potter, G. G., McQuoid, D. R., et al. (2017) ‘Longitudinal cognitive outcomes of clinical phenotypes of late-life depression’. Am J Geriatr Psychiatry 25: 1123–34.Google Scholar
Diniz, B. S., Butters, M. A., Albert, S. M., et al. (2013) ‘Late-life depression and risk of vascular dementia and Alzheimer’s disease: Systematic review and meta-analysis of community-based cohort studies’. Br J Psychiatry 202: 329–35.Google Scholar
Singh-Manoux, A., Dugravot, A., Fournier, A., et al. (2017) ‘Trajectories of depressive symptoms before diagnosis of dementia: A 28-year follow-up study’. JAMA Psychiatry 74: 712–18.Google Scholar
Ege, M. A., Messias, E., Thapa, P. B., Krain, L. P. (2015) ‘Adverse childhood experiences and geriatric depression: Results from the 2010 BRFSS’. Am J Geriatr Psychiatry 23: 110–14.CrossRefGoogle ScholarPubMed
Kasen, S., Chen, H., Sneed, J. R., Cohen, P. (2010) ‘Earlier stress exposure and subsequent major depression in aging women’. Int J Geriatr Psychiatry 25: 91–9.CrossRefGoogle ScholarPubMed
van der Veen, D. C., van Dijk, S. D. M., Comijs, H. C., et al. (2017) ‘The importance of personality and life-events in anxious depression: From trait to state anxiety’. Aging Mental Health 21: 1177–83.CrossRefGoogle ScholarPubMed
Aziz, R., Steffans, D. C. (2013) ‘What are the causes of late life depression?’ Psychiatr Clin N Am 36: 497–516.Google Scholar
Pellicano, C., Benincasa, D., Pisani, V., et al. (2007) ‘Prodromal non-motor symptoms of Parkinson’s disease’. Neuropsychiatr Dis Treat 3: 145–52.Google Scholar
Seymour, J., Benning, T. B. (2009) ‘Depression, cardiac mortality and all-cause mortality’. Adv Psychiatr Treatment 15: 107–13.CrossRefGoogle Scholar
Alexopoulos, A., Meyers, B., Young, R., et al. (1997) ‘“Vascular Depression” hypothesis’. Arch Gen Psychiatry 54: 915–922.CrossRefGoogle ScholarPubMed
Qiu, W. Q., Himali, J. J., Wolf, P. A., et al. (2017) ‘Effects of white matter integrity and brain volumes on late life depression in the Framingham Heart Study’. Int J Geriatr Psychiatry 32: 214–21.Google Scholar
Armstrong, N. M., Meoni, L. A., Carlson, M. C., et al. (2017) ‘Cardiovascular risk factors and risk of incident depression throughout adulthood among men: The Johns Hopkins Precursors Study’. J Affect Disord 214: 60–6.Google Scholar
Oldehinkel, A., Ormel, J., Brilman, E. (2003) ‘Psychosocial and vascular risk factors of depression in later life’. J Affect Disord 74: 237–46.Google Scholar
Steffans, D., Pieper, C., Bosworth, H., et al. (2005) ‘Biological and social predictors of long-term geriatric depression outcome’. Int Psychogeriatrics 17: 41–56.CrossRefGoogle Scholar
Jacobsen, J. J., Maytal, G., Stern, T. A. (2007) ‘Demoralization in medical practice’. Prim Care Companion J Clin Psychiatry 9: 139–43.Google Scholar
Baldwin, R. C. (2010) ‘Preventing late-life depression: A clinical update’. Int Psychogeriatrics 22: 1216–24.CrossRefGoogle ScholarPubMed
Farrer, L., Leach, L., Griffiths, K. M., et al. (2008) ‘Age differences in mental health literacy’. BMC Public Health 8: 125–32.Google Scholar
Cuijpers, P., Karyotaki, E., Pot, A. M., et al. (2014) ‘Managing depression in older age: Psychological interventions’. Maturitas 79: 160–9.Google Scholar
Alexopoulos, G. S., O’Neil, R., Banerjee, S., et al. (2017) ‘“Engage” therapy: Prediction of change of late-life major depression’. J Affect Disord 221: 192–7.Google Scholar
Naismith, S. L., Diamond, K., Carter, P. B., et al. (2011) ‘Enhancing memory in late-life depression: The effects of a combined psychoeducation and cognitive training program’. Am J Geriatr Psychiatry 19: 240–8.Google Scholar
Kok, R. M. (2013) ‘What is the role of medication in late life depression?’ Psychiatr Clin N Am 36: 597–605.CrossRefGoogle ScholarPubMed
Kok, R. M., Heeren, T. J., Nolen, W. A. (2011) ‘Continuing treatment of depression in the elderly: A systematic review and meta-analysis of double-blind randomized controlled trials with antidepressants’. Am J Geriatr Psychiatry 19: 249–55.CrossRefGoogle Scholar
Kellner, C. H., Husain, M. M., Knapp, R. G., et al. (2016) ‘Right unilateral ultrabrief pulse ECT in geriatric depression: Phase 1 of the PRIDE Study’. Am J Psychiatry 173: 1101–9.Google Scholar
Ford, A. H., Almeida, O. P. (2017) ‘Management of depression in patients with dementia: Is pharmacological treatment justified?’ Drugs Aging 34: 89–95.Google Scholar
Verkaik, R., Francke, A. L., van Meijel, B., et al. (2009) ‘Comorbid depression in dementia on psychogeriatric nursing home wards: Which symptoms are prominent?’ Am J Geriatr Psychiatry 17: 565–73.Google Scholar
Banerjee, S., Hellier, J., Dewey, M., et al. (2011) ‘Sertraline or mirtazapine for depression in dementia (HTA-SADD): A randomised, multicentre, double-blind, placebo-controlled trial’. Lancet 378: 403–11.Google Scholar
Ortega, V., Qazi, A., Spector, A., Orrell, M. (2015) ‘Psychological treatments for depression and anxiety in dementia and mild cognitive impairment: Systematic review and meta-analysis’. Br J Psychiatry 207: 293–8.Google Scholar
Draper, B. M. (2014) ‘Suicidal behaviour and suicide prevention in later life’. Maturitas 79: 179–83.Google Scholar
Cooper, C., Rantell, K., Blanchard, M., et al. (2015) ‘Why are suicidal thoughts less prevalent in older age groups? Age differences in the correlates of suicidal thoughts in the English Adult Psychiatric Morbidity Survey 2007’. J Affect Disord 177: 42–8.Google Scholar
Handley, T. E., Hiles, S. A., Inder, K. J., et al. (2014) ‘Predictors of suicidal ideation in older people: A decision tree analysis’. Am J Geriatr Psychiatry 22: 1325–35.CrossRefGoogle ScholarPubMed
Beekman, A. T., Geerlings, S. W., Deeg, D. J., et al. (2002) ‘The natural history of late-life depression: A 6-year prospective study in the community’. Arch Gen Psychiatry 59: 605–11.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×