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Chapter 2 - Normal Anatomy and Function of Lymph Nodes

from Section I - General Hematology and Hematopathology

Published online by Cambridge University Press:  25 January 2024

By
Xiayuan Liang
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

The immune system, a host defense system, recognizes foreign antigens and defends against invading microorganisms. It consists of primary (central) and secondary (peripheral) lymphoid organs. Primary lymphoid organs include the bone marrow and thymus, which contain lymphoid precursors and support initial antigen-independent differentiation from the immature stage to the mature stage. Secondary lymphoid organs comprise the lymph nodes, spleen, and sites of mucosa-associated lymphoid tissue, including the tonsils, appendix, and Peyer patches of the gastrointestinal tract, where antigen-dependent proliferation and differentiation of B- and T-lymphocytes take place [1].

Type
Chapter
Information
Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 5 - 8
Publisher: Cambridge University Press
Print publication year: 2024

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References

Medeiros, LJ, O’Malley, DP, Caraway, NP, et al. Normal anatomy and function of lymph nodes and spleen. In: Tumors of the lymph nodes and spleen. Washington, DC: American Registry of Pathology; 2017:1–16.Google Scholar
Proytcheva, MA. Reactive lymphadenopathies. In: Proytcheva, MA, ed. Diagnostic pediatric hematopathology. Cambridge, UK: Cambridge University Press; 2011:142–81.Google Scholar
O’Malley, DP, George, TI, Orazi, A, et al. Embryology and histology of the lymph node and spleen. In: Benign and reactive conditions of lymph nodes and spleen. Washington, DC: American Registry of Pathology; 2009:19–56.CrossRefGoogle Scholar
Crivellato, E, Vacca, A, Ribatti, D. Setting the stage: an anatomist’s view of the immune system. Trends in Immunology. 2004;25:210–17.Google Scholar
Scholzen, T, Gerde, J. The Ki-67 protein: from the known and the unknown. J Cell Physiol. 2000;182:311–322.Google Scholar

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