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Chapter 7 - Non-Infectious Lymphadenopathy

from Section III - Non-Neoplastic Disorders of Extramedullary Lymphoid Tissues

Published online by Cambridge University Press:  25 January 2024

By
Xiayuan Liang
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Benign enlargement of the lymph nodes or other lymphoid organs (e.g., tonsil, spleen, thymus) is a consequence of hyperplasia of some or all of the cellular components, reflecting stimulation of the lymphoid cells or other cells by a variety of pathogens. The common causes include autoimmune disorders, drug or allergen exposures, foreign body reaction, infection with microorganisms, or undetermined etiologies. Its incidence and etiology vary with age. In the majority of children, lymph node enlargement is transient and reversible. When a biopsy is needed for clinical management purposes, the primary goal of histologic evaluation is to determine the nature of the process: whether it is a benign or malignant, hematopoietic or non-hematopoietic cell proliferation.

Type
Chapter
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Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 67 - 83
Publisher: Cambridge University Press
Print publication year: 2024

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