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Chapter 22 - Hodgkin Lymphoma

from Section V - Mature Lymphoid Neoplasms

Published online by Cambridge University Press:  25 January 2024

By
Xiayuan Liang
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Hodgkin lymphoma (HL) is a family of unique B-lineage lymphoma subtypes and encompasses two morphologically, immunophenotypically, and clinically distinct categories: classic Hodgkin lymphoma (CHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). HL usually affects the lymph nodes and is composed of a small number of large, dysplastic mononuclear and multinucleated neoplastic cells (Hodgkin/Reed-Sternberg [HRS] cells, or lymphocyte-predominant [LP] cells/lymphocytic and histiocytic [L&H] cells) set in the background of benign inflammatory elements with or without abundant band-like and/or more diffuse collagen fibrosis. The neoplastic cells are often surrounded by T-lymphocytes [1,2].

The difference between NLPHL and CHL is that the B-cell program is generally preserved, and the neoplastic cells exhibit the overt B-lineage phenotype in NLPHL, but the neoplastic cells in CHL display an aberrant differentiation program with a characteristic CD15+, CD30+, and CD45– immunophenotype [1,2].

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Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 285 - 295
Publisher: Cambridge University Press
Print publication year: 2024

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References

Stein, H, Pileri, SA, Weiss, LM, et al. Hodgkin lymphomas: Introduction. In: Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissue. Rev. 4th ed. Lyon, France:IARC Press; 2017:424–30.Google Scholar
Onciu, M. Hodgkin lymphomas. In: Proytcheva, MA, ed. Diagnostic pediatric hematopathology. Cambridge, UK: Cambridge University Press; 2011:465–83.Google Scholar
Jaffe, ES, Stein, H, Swerdlow, SH. Classic Hodgkin lymphomas. In: Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissue. Rev. 4th ed.Lyon, France:IARC Press; 2017:435.Google Scholar
Fend, F. Classical Hodgkin’s lymphoma and related lesions. In: Jaffe, ES, Arber, DA, Campo, E, et al., eds. Hematopathology. 2nd ed. Philadelphia, PA: Elsevier; 2017:525–45.Google Scholar
Mathas, S, Hartmann, S, Küppers, R. Hodgkin lymphoma: pathology and biology. Seminars Hematol. 2016; 53(3):139–47.Google Scholar
Mack, TM, Cozen, W, Shibata, DK, et al. Concordance for Hodgkin’s disease in identical twins suggesting genetic susceptibility to the young-adult form of the disease. N Engl J Med. 1995;332:413–9.Google Scholar
Horwitz, M, Wiernik, PH. Pseudoautosomal linkage of Hodgkin disease. Am J Hum Genet. 1999;65:1413–22.Google Scholar
Paltiel, O. Family matters in Hodgkin lymphoma. Leuk Lymphoma. 2008;49:1234–5.Google Scholar
Stein, H, Pileri, SA, MacLennan, KA, et al. Nodular sclerosis classic Hodgkin lymphoma. In: Swerdlow, SH, Campo, E, Harris, NL et al. eds. WHO classification of tumours of haematopoietic and lymphoid tissue. Rev. 4th ed. Lyon, France: IARC Press; 2017:435–7.Google Scholar
Weiss, LM, Poppema, S, Jaffe, E, et al. Mixed cellularity classic Hodgkin lymphoma. In: Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissue. Rev. 4th ed. Lyon, France:IARC Press; 2017:440.Google Scholar
Anagnostopoulos, I, Piris, MA, Isaacson, PG, et al. Lymphocyte-rich classic Hodgkin lymphoma. In: Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissue. Rev. 4th ed. Lyon, France:IARC Press; 2017:438–40.Google Scholar
Benharroch, D, Jaffe, E, Stein, H. Lymphocyte-depleted classic Hodgkin lymphoma. In: Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissue. Rev. 4th ed. Lyon, France: IARC Press; 2017:441–2.Google Scholar
Ansell, SM. Hodgkin lymphoma: A 2020 update on diagnosis, risk‐stratification, and management. Am J Hematol. 2020;95:978–89.Google Scholar
Stein, H, Swerdlow, SH, Gascoyne, RD, et al. Nodular lymphocyte predominant Hodgkin lymphoma. In: Swerdlow, SH, Campo, E, Harris, NL, et al., eds. WHO classification of tumours of haematopoietic and lymphoid tissue. Rev. 4th ed.Lyon, France:IARC Press; 2017:431–4.Google Scholar
Hartmann, S, Eichenauer, DA. Nodular lymphocyte predominant Hodgkin lymphoma: pathology, clinical course and relation to T-cell/histiocyte rich large B-cell lymphoma. Pathology. 2020;52:142–53.Google Scholar
Fan, Z, Natkunam, Y, Bair, E, et al. Characterization of variant patterns of nodular lymphocyte predominant Hodgkin lymphoma with immunohistologic and clinical correlation. Am J Surg Pathol. 2003;27:1346–56.Google Scholar
Boudová, L, Torlakovic, E, Delabie, J, et al. Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/histiocyte-rich B-cell lymphoma. Blood. 2003;102: 3753–8.Google Scholar
Franke, S, Wlodarska, I, Maes, B, et al. Comparative genomic hybridization pattern distinguishes T-cell/histiocyte-rich B-cell lymphoma from nodular lymphocyte predominance Hodgkin’s lymphoma. Am J Pathol. 2002;161:1861–7.Google Scholar

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