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Chapter 12 - Ambiguous Lineage and Mixed Phenotype Acute Leukaemia

Published online by Cambridge University Press:  30 January 2025

By
Anna Porwit  and
Marie-Christine Béné
Edited by
Anna Porwit  and
Marie Christine Béné
Anna Porwit
Affiliation:
Lunds Universitet, Sweden
Marie Christine Béné
Affiliation:
Université de Nantes, France
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Summary

Mixed-phenotype acute leukaemia is a generic classification item collecting leukaemias with two clones of different lineage or really abnormal cells expressing markers of several lineages. Their identification relies on both morphological and immunophenotypic features. From a cytogenetic/molecular point of view, their heterogeneity is amazing. Clinical management of such patients is getting progressively better stratified, allogeneic hematopoietic stem cell transplantation remaining the best option, with a possibly better approach for patients with Philadelphia chromosome. This is a typical example of the need for integrated diagnosis.

Keywords

flow cytometryimmunophenotypingmixed phenotype acute leukemiabiclonalpanelB-lineageT-lineagemyeloid lineagemyeloperoxidase (MPO)KMT2A, BCR-ABL1
Type
Chapter
Information
Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies , pp. 193 - 202
Publisher: Cambridge University Press
Print publication year: 2025

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