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Chapter 18 - Resective Surgery for Medication-Resistant Epilepsy

Published online by Cambridge University Press:  20 August 2020

By
Barbara C. Jobst  and
Krzyszof A. Bujarski
Edited by
John M. Stern ,
Raman Sankar  and
Michael Sperling
John M. Stern
Affiliation:
Geffen School of Medicine at UCLA, Los Angeles, CA
Raman Sankar
Affiliation:
Geffen School of Medicine at UCLA, Los Angeles, CA
Michael Sperling
Affiliation:
Jefferson Hospital for Neurosciences, Philadelphia, PA
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Summary

Resective epilepsy surgery is to date the most effective treatment for focal medication-resistant epilepsy. In multiple retrospective studies the median percentage for remaining seizure-free is approximately 60–65%, depending on the epilepsy syndrome [1]. Surgery for epilepsy was pioneered by Penfield in the first part of the twentieth century and has been refined since, with advanced imaging and neurophysiologic recordings [2]. Despite the obvious success, surgery remains underutilized [1,3]. If seizures are focal in onset and medication resistant, which is defined by the ILAE as having failed two anti-epileptic medications at standard doses, surgical evaluation at a specialized centre is indicated [4].

Type
Chapter
Information
Medication-Resistant Epilepsy
Diagnosis and Treatment
 , pp. 198 - 209
Publisher: Cambridge University Press
Print publication year: 2020

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References

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