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Chapter 10 - Malformations of Cortical Development as Causes of Medication-Resistant Epilepsy

Published online by Cambridge University Press:  20 August 2020

By
Ruben Kuzniecky
Edited by
John M. Stern ,
Raman Sankar  and
Michael Sperling
John M. Stern
Affiliation:
Geffen School of Medicine at UCLA, Los Angeles, CA
Raman Sankar
Affiliation:
Geffen School of Medicine at UCLA, Los Angeles, CA
Michael Sperling
Affiliation:
Jefferson Hospital for Neurosciences, Philadelphia, PA
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Summary

Malformations of cortical development (MCD) are by now well recognized causes of neurodevelopmental disorders and epilepsy [1]. The precise etiological mechanisms, clinical features and course vary as patients present with a wide range of developmental disorders, associated somatic and cortical malformations, and epilepsy. Specific clinical phenotypes can be recognized in a proportion of patients based on common clinical and imaging features. Furthermore, genetic testing allows for specific phenotype–genotype classification. However, as with many genetic disorders, the phenotypic variability is large, presenting a challenge to the diagnosis and clinical management of these patients.

Type
Chapter
Information
Medication-Resistant Epilepsy
Diagnosis and Treatment
 , pp. 79 - 86
Publisher: Cambridge University Press
Print publication year: 2020

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