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26 - Pathophysiology and principles of management of the diabetic foot

Published online by Cambridge University Press:  05 June 2012

Robert Fitridge
Affiliation:
University of Adelaide
Matthew Thompson
Affiliation:
St George's Hospital Medical School, London, UK
David G. Armstrong
Affiliation:
The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA
Timothy K. Fisher
Affiliation:
Rashid Centre for Diabetes and Research, Sheikh Khalifa Hospital, Ajman, UAE
Brian Lepow
Affiliation:
The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA
Matthew L. White
Affiliation:
Vascular and Endovascular Surgery, University of Arizona, Tucson, Arizona, USA
Joseph L. Mills
Affiliation:
The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA; Vascular and Endovascular Surgery, University of Arizona, Tucson, Arizona, USA
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Summary

INTRODUCTION

The incidence of diabetes continues to grow at a staggering pace. The United States' Centers for Disease Control and Prevention estimate that 23.6 million people or 7.8% of the U.S. Population has diabetes, with 1.6 million new cases being diagnosed each year. These figures are even more astonishing when one considers worldwide estimates. Close to 4 million deaths in the 20–79 year old age group may be attributed to diabetes in 2010, accounting for 6.8% of global all-cause mortality in this age group. The number of people with diabetes worldwide is expected to reach 366 million people by 2030, more than double the estimated 177 million people affected with the disease in 2000. The increased disease prevalence is accompanied by an increase in associated comorbidities. The literature estimates that patients with diabetes have nearly a 25% lifetime risk of developing a foot ulcer with more than 50% of these ulcers becoming infected and requiring hospitalization. In fact, at least 20% of all diabetes-related hospital admissions are due to diabetic foot ulcers. Associated with foot ulcers and infection is the incidence of amputation. It has been conservatively reported that, worldwide, a major amputation takes place every 30 seconds with over 2500 limbs lost per day. At least 60% of all non-traumatic lower extremity amputations are related to complications of diabetes. People with diabetes who have had one amputation have a 68% risk of having another in the next 5 years and have a 50% mortality rate in the 5 years following the initial amputation.

Type
Chapter
Information
Mechanisms of Vascular Disease
A Reference Book for Vascular Specialists
, pp. 475 - 496
Publisher: The University of Adelaide Press
Print publication year: 2011

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  • Pathophysiology and principles of management of the diabetic foot
    • By David G. Armstrong, The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA, Timothy K. Fisher, Rashid Centre for Diabetes and Research, Sheikh Khalifa Hospital, Ajman, UAE, Brian Lepow, The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA, Matthew L. White, Vascular and Endovascular Surgery, University of Arizona, Tucson, Arizona, USA, Joseph L. Mills, The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA; Vascular and Endovascular Surgery, University of Arizona, Tucson, Arizona, USA
  • Robert Fitridge, University of Adelaide, Matthew Thompson, St George's Hospital Medical School, London, UK
  • Book: Mechanisms of Vascular Disease
  • Online publication: 05 June 2012
  • Chapter DOI: https://doi.org/10.1017/UPO9781922064004.027
Available formats
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  • Pathophysiology and principles of management of the diabetic foot
    • By David G. Armstrong, The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA, Timothy K. Fisher, Rashid Centre for Diabetes and Research, Sheikh Khalifa Hospital, Ajman, UAE, Brian Lepow, The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA, Matthew L. White, Vascular and Endovascular Surgery, University of Arizona, Tucson, Arizona, USA, Joseph L. Mills, The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA; Vascular and Endovascular Surgery, University of Arizona, Tucson, Arizona, USA
  • Robert Fitridge, University of Adelaide, Matthew Thompson, St George's Hospital Medical School, London, UK
  • Book: Mechanisms of Vascular Disease
  • Online publication: 05 June 2012
  • Chapter DOI: https://doi.org/10.1017/UPO9781922064004.027
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Pathophysiology and principles of management of the diabetic foot
    • By David G. Armstrong, The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA, Timothy K. Fisher, Rashid Centre for Diabetes and Research, Sheikh Khalifa Hospital, Ajman, UAE, Brian Lepow, The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA, Matthew L. White, Vascular and Endovascular Surgery, University of Arizona, Tucson, Arizona, USA, Joseph L. Mills, The University of Arizona, Southern Arizona Limb Salvage Alliance (SALSA), Tucson, Arizona, USA; Vascular and Endovascular Surgery, University of Arizona, Tucson, Arizona, USA
  • Robert Fitridge, University of Adelaide, Matthew Thompson, St George's Hospital Medical School, London, UK
  • Book: Mechanisms of Vascular Disease
  • Online publication: 05 June 2012
  • Chapter DOI: https://doi.org/10.1017/UPO9781922064004.027
Available formats
×