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Chapter 46 - Ataxia

from Section 4: - Dyscoordinative and Otherwise Inappropriate Motor Behaviors

Published online by Cambridge University Press:  07 January 2025

By
Berry Kremer  and
Alexander A. Tarnutzer
Edited by
Erik Ch. Wolters  and
Christian R. Baumann
Erik Ch. Wolters
Affiliation:
Universität Zürich
Christian R. Baumann
Affiliation:
Universität Zürich
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Summary

"Ataxia" refers to both the neurologic syndrome of motor coordination and to a large and diverse group of diseases that have motor coordination impairment as their main clinical feature. The brain structure most consistently affected is the cerebellum. Although many different brain diseases may manifest with ataxia, the vast majority of slowly progressive ataxias are genetic diseases. Indeed, genetic molecular analysis has become the cornerstone of both diagnosis and classification of this complex group of conditions. In this overview, the basics of the clinical features and the classification of these diseases, as well as common conditions, and recently defined novel forms of ataxia are discussed.

Keywords

ataxiaspinocerebellar ataxiacerebellumgait disorderseye movementsvestibularpathophysiologyhereditarygenetics
Type
Chapter
Information
International Compendium of Movement Disorders , pp. 568 - 591
Publisher: Cambridge University Press
Print publication year: 2025

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