Book contents
- Frontmatter
- Contents
- Editor, Associate Editors, Artistic Consultant, and Contributors
- Preface
- PART I CONTEXT
- PART II ENDOTHELIAL CELL AS INPUT-OUTPUT DEVICE
- 27 Introductory Essay: Endothelial Cell Input
- 28 Hemodynamics in the Determination of Endothelial Phenotype and Flow Mechanotransduction
- 29 Hypoxia-Inducible Factor 1
- 30 Integrative Physiology of Endothelial Cells: Impact of Regional Metabolism on the Composition of Blood-Bathing Endothelial Cells
- 31 Tumor Necrosis Factor
- 32 Vascular Permeability Factor/Vascular Endothelial Growth Factor and Its Receptors: Evolving Paradigms in Vascular Biology and Cell Signaling
- 33 Function of Hepatocyte Growth Factor and Its Receptor c-Met in Endothelial Cells
- 34 Fibroblast Growth Factors
- 35 Transforming Growth Factor-β and the Endothelium
- 36 Thrombospondins
- 37 Neuropilins: Receptors Central to Angiogenesis and Neuronal Guidance
- 38 Vascular Functions of Eph Receptors and Ephrin Ligands
- 39 Endothelial Input from the Tie1 and Tie2 Signaling Pathway
- 40 Slits and Netrins in Vascular Patterning: Taking Cues from the Nervous System
- 41 Notch Genes: Orchestrating Endothelial Differentiation
- 42 Reactive Oxygen Species
- 43 Extracellular Nucleotides and Nucleosides as Autocrine and Paracrine Regulators within the Vasculature
- 44 Syndecans
- 45 Sphingolipids and the Endothelium
- 46 Endothelium: A Critical Detector of Lipopolysaccharide
- 47 Receptor for Advanced Glycation End-products and the Endothelium: A Path to the Complications of Diabetes and Inflammation
- 48 Complement
- 49 Kallikrein-Kinin System
- 50 Opioid Receptors in Endothelium
- 51 Snake Toxins and Endothelium
- 52 Inflammatory Cues Controlling Lymphocyte–Endothelial Interactions in Fever-Range Thermal Stress
- 53 Hyperbaric Oxygen and Endothelial Responses in Wound Healing and Ischemia–Reperfusion Injury
- 54 Barotrauma
- 55 Endothelium and Diving
- 56 Exercise and the Endothelium
- 57 The Endothelium at High Altitude
- 58 Endothelium in Space
- 59 Toxicology and the Endothelium
- 60 Pericyte–Endothelial Interactions
- 61 Vascular Smooth Muscle Cells: The Muscle behind Vascular Biology
- 62 Cross-Talk between the Red Blood Cell and the Endothelium: Nitric Oxide as a Paracrine and Endocrine Regulator of Vascular Tone
- 63 Leukocyte–Endothelial Cell Interactions
- 64 Platelet–Endothelial Interactions
- 65 Cardiomyocyte–Endothelial Cell Interactions
- 66 Interactions between Hepatocytes and Liver Sinusoidal Endothelial Cells
- 67 Stellate Cell–Endothelial Cell Interactions
- 68 Podocyte–Endothelial Interactions
- 69 Introductory Essay: Endothelial Cell Coupling
- 70 Endothelial and Epithelial Cells: General Principles of Selective Vectorial Transport
- 71 Electron Microscopic–Facilitated Understanding of Endothelial Cell Biology: Contributions Established during the 1950s and 1960s
- 72 Weibel-Palade Bodies: Vesicular Trafficking on the Vascular Highways
- 73 Multiple Functions and Clinical Uses of Caveolae in Endothelium
- 74 Endothelial Structures Involved in Vascular Permeability
- 75 Endothelial Luminal Glycocalyx: Protective Barrier between Endothelial Cells and Flowing Blood
- 76 The Endothelial Cytoskeleton
- 77 Endothelial Cell Integrins
- 78 Aquaporin Water Channels and the Endothelium
- 79 Ion Channels in Vascular Endothelium
- 80 Regulation of Angiogenesis and Vascular Remodeling by Endothelial Akt Signaling
- 81 Mitogen-Activated Protein Kinases
- 82 Protein Kinase C
- 83 Rho GTP-Binding Proteins
- 84 Protein Tyrosine Phosphatases
- 85 Role of β-Catenin in Endothelial Cell Function
- 86 Nuclear Factor-κB Signaling in Endothelium
- 87 Peroxisome Proliferator-Activated Receptors and the Endothelium
- 88 GATA Transcription Factors
- 89 Coupling: The Role of Ets Factors
- 90 Early Growth Response-1 Coupling in Vascular Endothelium
- 91 KLF2: A “Molecular Switch” Regulating Endothelial Function
- 92 NFAT Transcription Factors
- 93 Forkhead Signaling in the Endothelium
- 94 Genetics of Coronary Artery Disease and Myocardial Infarction: The MEF2 Signaling Pathway in the Endothelium
- 95 Vezf1: A Transcriptional Regulator of the Endothelium
- 96 Sox Genes: At the Heart of Endothelial Transcription
- 97 Id Proteins and Angiogenesis
- 98 Introductory Essay: Endothelial Cell Output
- 99 Proteomic Mapping of Endothelium and Vascular Targeting in Vivo
- 100 A Phage Display Perspective
- 101 Hemostasis and the Endothelium
- 102 Von Willebrand Factor
- 103 Tissue Factor Pathway Inhibitor
- 104 Tissue Factor Expression by the Endothelium
- 105 Thrombomodulin
- 106 Heparan Sulfate
- 107 Antithrombin
- 108 Protein C
- 109 Vitamin K–Dependent Anticoagulant Protein S
- 110 Nitric Oxide as an Autocrine and Paracrine Regulator of Vessel Function
- 111 Heme Oxygenase and Carbon Monoxide in Endothelial Cell Biology
- 112 Endothelial Eicosanoids
- 113 Regulation of Endothelial Barrier Responses and Permeability
- 114 Molecular Mechanisms of Leukocyte Transendothelial Cell Migration
- 115 Functions of Platelet-Endothelial Cell Adhesion Molecule-1 in the Vascular Endothelium
- 116 P-Selectin
- 117 Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1
- 118 E-Selectin
- 119 Endothelial Cell Apoptosis
- 120 Endothelial Antigen Presentation
- PART III VASCULAR BED/ORGAN STRUCTURE AND FUNCTION IN HEALTH AND DISEASE
- PART IV DIAGNOSIS AND TREATMENT
- PART V CHALLENGES AND OPPORTUNITIES
- Index
- Plate section
53 - Hyperbaric Oxygen and Endothelial Responses in Wound Healing and Ischemia–Reperfusion Injury
from PART II - ENDOTHELIAL CELL AS INPUT-OUTPUT DEVICE
Published online by Cambridge University Press: 04 May 2010
Edited by
Book contents
- Frontmatter
- Contents
- Editor, Associate Editors, Artistic Consultant, and Contributors
- Preface
- PART I CONTEXT
- PART II ENDOTHELIAL CELL AS INPUT-OUTPUT DEVICE
- 27 Introductory Essay: Endothelial Cell Input
- 28 Hemodynamics in the Determination of Endothelial Phenotype and Flow Mechanotransduction
- 29 Hypoxia-Inducible Factor 1
- 30 Integrative Physiology of Endothelial Cells: Impact of Regional Metabolism on the Composition of Blood-Bathing Endothelial Cells
- 31 Tumor Necrosis Factor
- 32 Vascular Permeability Factor/Vascular Endothelial Growth Factor and Its Receptors: Evolving Paradigms in Vascular Biology and Cell Signaling
- 33 Function of Hepatocyte Growth Factor and Its Receptor c-Met in Endothelial Cells
- 34 Fibroblast Growth Factors
- 35 Transforming Growth Factor-β and the Endothelium
- 36 Thrombospondins
- 37 Neuropilins: Receptors Central to Angiogenesis and Neuronal Guidance
- 38 Vascular Functions of Eph Receptors and Ephrin Ligands
- 39 Endothelial Input from the Tie1 and Tie2 Signaling Pathway
- 40 Slits and Netrins in Vascular Patterning: Taking Cues from the Nervous System
- 41 Notch Genes: Orchestrating Endothelial Differentiation
- 42 Reactive Oxygen Species
- 43 Extracellular Nucleotides and Nucleosides as Autocrine and Paracrine Regulators within the Vasculature
- 44 Syndecans
- 45 Sphingolipids and the Endothelium
- 46 Endothelium: A Critical Detector of Lipopolysaccharide
- 47 Receptor for Advanced Glycation End-products and the Endothelium: A Path to the Complications of Diabetes and Inflammation
- 48 Complement
- 49 Kallikrein-Kinin System
- 50 Opioid Receptors in Endothelium
- 51 Snake Toxins and Endothelium
- 52 Inflammatory Cues Controlling Lymphocyte–Endothelial Interactions in Fever-Range Thermal Stress
- 53 Hyperbaric Oxygen and Endothelial Responses in Wound Healing and Ischemia–Reperfusion Injury
- 54 Barotrauma
- 55 Endothelium and Diving
- 56 Exercise and the Endothelium
- 57 The Endothelium at High Altitude
- 58 Endothelium in Space
- 59 Toxicology and the Endothelium
- 60 Pericyte–Endothelial Interactions
- 61 Vascular Smooth Muscle Cells: The Muscle behind Vascular Biology
- 62 Cross-Talk between the Red Blood Cell and the Endothelium: Nitric Oxide as a Paracrine and Endocrine Regulator of Vascular Tone
- 63 Leukocyte–Endothelial Cell Interactions
- 64 Platelet–Endothelial Interactions
- 65 Cardiomyocyte–Endothelial Cell Interactions
- 66 Interactions between Hepatocytes and Liver Sinusoidal Endothelial Cells
- 67 Stellate Cell–Endothelial Cell Interactions
- 68 Podocyte–Endothelial Interactions
- 69 Introductory Essay: Endothelial Cell Coupling
- 70 Endothelial and Epithelial Cells: General Principles of Selective Vectorial Transport
- 71 Electron Microscopic–Facilitated Understanding of Endothelial Cell Biology: Contributions Established during the 1950s and 1960s
- 72 Weibel-Palade Bodies: Vesicular Trafficking on the Vascular Highways
- 73 Multiple Functions and Clinical Uses of Caveolae in Endothelium
- 74 Endothelial Structures Involved in Vascular Permeability
- 75 Endothelial Luminal Glycocalyx: Protective Barrier between Endothelial Cells and Flowing Blood
- 76 The Endothelial Cytoskeleton
- 77 Endothelial Cell Integrins
- 78 Aquaporin Water Channels and the Endothelium
- 79 Ion Channels in Vascular Endothelium
- 80 Regulation of Angiogenesis and Vascular Remodeling by Endothelial Akt Signaling
- 81 Mitogen-Activated Protein Kinases
- 82 Protein Kinase C
- 83 Rho GTP-Binding Proteins
- 84 Protein Tyrosine Phosphatases
- 85 Role of β-Catenin in Endothelial Cell Function
- 86 Nuclear Factor-κB Signaling in Endothelium
- 87 Peroxisome Proliferator-Activated Receptors and the Endothelium
- 88 GATA Transcription Factors
- 89 Coupling: The Role of Ets Factors
- 90 Early Growth Response-1 Coupling in Vascular Endothelium
- 91 KLF2: A “Molecular Switch” Regulating Endothelial Function
- 92 NFAT Transcription Factors
- 93 Forkhead Signaling in the Endothelium
- 94 Genetics of Coronary Artery Disease and Myocardial Infarction: The MEF2 Signaling Pathway in the Endothelium
- 95 Vezf1: A Transcriptional Regulator of the Endothelium
- 96 Sox Genes: At the Heart of Endothelial Transcription
- 97 Id Proteins and Angiogenesis
- 98 Introductory Essay: Endothelial Cell Output
- 99 Proteomic Mapping of Endothelium and Vascular Targeting in Vivo
- 100 A Phage Display Perspective
- 101 Hemostasis and the Endothelium
- 102 Von Willebrand Factor
- 103 Tissue Factor Pathway Inhibitor
- 104 Tissue Factor Expression by the Endothelium
- 105 Thrombomodulin
- 106 Heparan Sulfate
- 107 Antithrombin
- 108 Protein C
- 109 Vitamin K–Dependent Anticoagulant Protein S
- 110 Nitric Oxide as an Autocrine and Paracrine Regulator of Vessel Function
- 111 Heme Oxygenase and Carbon Monoxide in Endothelial Cell Biology
- 112 Endothelial Eicosanoids
- 113 Regulation of Endothelial Barrier Responses and Permeability
- 114 Molecular Mechanisms of Leukocyte Transendothelial Cell Migration
- 115 Functions of Platelet-Endothelial Cell Adhesion Molecule-1 in the Vascular Endothelium
- 116 P-Selectin
- 117 Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1
- 118 E-Selectin
- 119 Endothelial Cell Apoptosis
- 120 Endothelial Antigen Presentation
- PART III VASCULAR BED/ORGAN STRUCTURE AND FUNCTION IN HEALTH AND DISEASE
- PART IV DIAGNOSIS AND TREATMENT
- PART V CHALLENGES AND OPPORTUNITIES
- Index
- Plate section
Summary
Hyperbaric oxygen (HBO2) therapy is defined as breathing 100% oxygen (O2) at a pressure greater than 1.4 atmospheres absolute (ATA) (1). HBO2 is currently accepted as a clinical adjunctive therapy for the following indications: wound healing, carbon monoxide (CO) poisoning, crush injury, clostridial myositis and myonecrosis, decompression sickness, osteomyelitis (refractory), skin grafts and flaps, and air or gas embolism (1–3). HBO2 therapy is administered in either a monoplace hyperbaric chamber (where the chamber is compressed with 100% oxygen) or in a multiplace hyperbaric chamber (where the chamber is compressed with air and the patient breathes 100% oxygen via a tight-fitting mask or hood) (Figure 53.1).Many benefits of HBO2 therapy are gained through its effects on the endothelium, including improvements in microvascular flow, induction of proangiogenic factors, inhibition of inducible intercellular adhesion molecule (ICAM)–1 expression, and regulation of endothelial derived nitric oxide (NO) production. The ubiquitous nature of the endothelium provides a gateway for many of the HBO2 protective mechanisms to be effective at a number of injury sites. This chapter reviews the effects of HBO2 therapy on disease states that are most dependent on endothelial responses: wound healing and ischemia–reperfusion (I/R) injury.
HISTORY OF HYPERBARIC OXYGEN THERAPY
HBO2 therapy was born from the concept that individuals exposed to increased ambient air pressure would have improvement in many different disease states (4). Although there was no scientific basis for this concept, it was put into practice as early as 1662 by a British clergyman, Henshaw (5). Compressed-air therapy enjoyed a nonscientifically founded popularity during the 19th century in a manner similar to mineral water spas (6).
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- Chapter
- Information
- Endothelial Biomedicine , pp. 480 - 488Publisher: Cambridge University PressPrint publication year: 2007