Field experiments were conducted to evaluate common cocklebur and entireleaf morningglory interference on soybean under irrigated and nonirrigated conditions. Total leaf area index (LAI), LAI within the soybean canopy, crop growth rate, and seed yield of soybean were decreased more by common cocklebur than by entireleaf morningglory. Interference from entireleaf morningglory, common cocklebur, or both species reduced soybean yields 21, 57, and 64%, respectively, with irrigation and 12, 60, and 76%, respectively, without irrigation. Soybean yield reduction from interference with entireleaf morningglory, common cocklebur, or both species was not influenced by soybean date of planting. Soil water was extracted from greater soil depths by soybean growing with the weeds than by soybean alone. High WUE without irrigation suggests that soybean uses water more efficiently when soil moisture is limiting than when soil moisture is available under irrigated conditions.