Greenhouse experiments were conducted to determine the effects of herbicide placement on POST smooth crabgrass and annual bluegrass control. Soil-plus-foliar, soil-only, and foliar-only applications of indaziflam (52.5 g ai ha−1), dithiopyr (560 ai g ha−1), or quinclorac (840 g ai ha−1) were made to one-tiller smooth crabgrass plants. Similarly, indaziflam (52.5 g ha−1), foramsulfuron (29 g ai ha−1), or prodiamine (840 g ai ha−1) were applied to nontillering annual bluegrass plants in an identical manner. No differences in smooth crabgrass control were detected between soil-plus-foliar and soil-only applied indaziflam from 21 to 35 d after treatment (DAT). By 28 DAT, smooth crabgrass control and biomass reductions with these indaziflam treatments were ≥ 90% and not different than quinclorac. Comparatively, smooth crabgrass control with foliar-only applications of indaziflam never exceeded 28%. Responses on annual bluegrass were similar as soil-plus-foliar and soil-only applied indaziflam exhibited greater efficacy than indaziflam applied foliar-only. By 28 DAT, annual bluegrass control and aboveground biomass reductions with soil-plus-foliar and soil-only treatments were ≥ 86% and not different from foramsulfuron. Comparatively, foliar-only applications of indaziflam controlled annual bluegrass ≤ 2%. These results indicate that root absorption is required for POST control of smooth crabgrass and annual bluegrass with indaziflam. Further research is needed to determine if techniques to enhance indaziflam contact with soil will enhance POST smooth crabgrass and annual bluegrass control in the field.