The affect of mesosulfuron and tribenuron applied POST to oat and rye was determined at three locations in Georgia during 2004 and 2005. Five herbicide treatments were applied to oat and rye in Feekes scale (FS) 1.2 or 2 developmental stage. Herbicide treatments consisted of tribenuron at 13 or 26 g ai/ha, tribenuron at 13 g/ha plus MCPA at 561 g ai/ha, MCPA at 561 g/ha, and mesosulfuron at 15 g ai/ha. Tribenuron, MCPA, and tribenuron plus MCPA injured both crops less than 4% and did not affect grain yield. Mesosulfuron applied to rye in FS 1.2 injured the crop 36% at 2 wk after treatment (WAT), 12% at 5 WAT, and 0% at harvest. Mesosulfuron applied at FS 2 injured rye less than 9%. Mesosulfuron did not influence rye-grain yield with either application timing. Mesosulfuron injured oat 65 to 86% at 5 WAT and reduced yield at least 70% regardless of application timing.