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3 results

  • Effects of fat emulsion-based early parenteral nutrition for patients after hemihepatectomy

  • Leyi Liao, Yang Lei, Qinghua He, Hanbiao Liang, Jie Zhou, Kai Wang, Chuanjiang Li
  • Journal:
    British Journal of Nutrition , First View
    Published online by Cambridge University Press:
    24 March 2025, pp. 1-10

  • This study investigates the effects of fat emulsion-based early parenteral nutrition in patients following hemihepatectomy, addressing a critical gap in clinical knowledge regarding parenteral nutrition after hemihepatectomy. We retrospectively analysed clinical data from 274 patients who received non-fat emulsion-based parenteral nutrition (non-fatty nutrition group) and 297 patients who received fat emulsion-based parenteral nutrition (fatty nutrition group) after hemihepatectomy. Fat emulsion-based early parenteral nutrition significantly reduced levels of post-operative aspartate aminotransferase, total bilirubin and direct bilirubin, while minor decreases in red blood cell and platelet counts were observed in the fatty nutrition group. Importantly, fat emulsion-based early parenteral nutrition shortened lengths of post-operative hospital stay and fasting duration, but did not affect the incidence of short-term post-operative complications. Subgroup analyses revealed that the supplement of n-3 fish oil emulsions was significantly associated with a reduced inflammatory response and risk of post-operative infections. These findings indicate that fat emulsion-based early parenteral nutrition enhances short-term post-operative recovery in patients undergoing hemihepatectomy.

  • Platelet counts in depressed patients treated with amitriptyline or paroxetine

  • F. Lederbogen, E. Hörer, R. Hellweg, I. Heuser, M. Deuschle
  • Journal:
    European Psychiatry / Volume 18 / Issue 2 / March 2003
    Published online by Cambridge University Press:
    16 April 2020, pp. 89-91
  • Objective

    To assess whether therapy with two widely used antidepressants influences platelet counts.

    Subjects and methods

    In 90 patients hospitalized for treatment of a major depressive episode according to DSM-IV, platelet counts were performed after a 6 d antidepressant-free run-in period and again after 35 d of active standardized treatment with amitriptyline (n = 40) or paroxetine (n = 50).

    Results

    There was a trend for platelet counts to increase during treatment with amitriptyline (from 245.5 ± 68.6 to 256.8 ± 69 cells × 109 L-1, P < 0.06); no change was observed during treatment with paroxetine (from 232.6 ± 58.3 to 234.6 ± 68.9 cells × 109 L-1, n.s).

    Conclusions

    Treatment with amitriptyline tends to be associated with elevated platelet counts. The cause for this increase is not known, but may be relevant in terms of patients’ long-term thromboembolic risk.

  • 1 - The coagulation system in pregnancy

  • Edited by Ann Harper
  • Book:
    Haemorrhage and Thrombosis for the MRCOG and Beyond
    Published online:
    05 October 2014
    Print publication:
    01 June 2005, pp 1-15

  • Summary

    The changes in the coagulation system in normal pregnancy are consistent with a continuing low grade process of coagulant activity. Using electron microscopy, fibrin deposition can be demonstrated in the intervillous space of the placenta and in the walls of the spiral arteries supplying the placenta. Normal pregnancy is accompanied by dramatic changes in the coagulation and fibrinolytic systems, with a marked increase in some of the procoagulant factors, particularly fibrinogen, and suppression of fibrinolysis. Certain disease states specific to pregnancy have profound effects on platelet consumption, lifespan and function. A fall in the platelet count may precede any detectable rise in serum fibrin degradation products (FDP) in women subsequently developing pre-eclampsia. The most common platelet abnormality encountered in clinical practice is thrombocytopenia. During healthy pregnancy there is little change in antithrombin level but there is some decrease at parturition and an increase in the puerperium.