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Effects of fat emulsion-based early parenteral nutrition for patients after hemihepatectomy

Published online by Cambridge University Press:  24 March 2025

Leyi Liao ,
Yang Lei ,
Qinghua He ,
Hanbiao Liang ,
Jie Zhou ,
Kai Wang  and
Chuanjiang Li Open the ORCID record for Chuanjiang Li [Opens in a new window]
Leyi Liao
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Yang Lei
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Qinghua He
Affiliation:
Department of Hepatobiliary Surgery, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, People’s Republic of China
Hanbiao Liang
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Jie Zhou*
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Kai Wang*
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Chuanjiang Li*
Affiliation:
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
*
Corresponding authors: Jie Zhou; Email: [email protected], Kai Wang; Email: [email protected], Chuanjiang Li; Email: [email protected]
Corresponding authors: Jie Zhou; Email: [email protected], Kai Wang; Email: [email protected], Chuanjiang Li; Email: [email protected]
Corresponding authors: Jie Zhou; Email: [email protected], Kai Wang; Email: [email protected], Chuanjiang Li; Email: [email protected]
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Abstract

This study investigates the effects of fat emulsion-based early parenteral nutrition in patients following hemihepatectomy, addressing a critical gap in clinical knowledge regarding parenteral nutrition after hemihepatectomy. We retrospectively analysed clinical data from 274 patients who received non-fat emulsion-based parenteral nutrition (non-fatty nutrition group) and 297 patients who received fat emulsion-based parenteral nutrition (fatty nutrition group) after hemihepatectomy. Fat emulsion-based early parenteral nutrition significantly reduced levels of post-operative aspartate aminotransferase, total bilirubin and direct bilirubin, while minor decreases in red blood cell and platelet counts were observed in the fatty nutrition group. Importantly, fat emulsion-based early parenteral nutrition shortened lengths of post-operative hospital stay and fasting duration, but did not affect the incidence of short-term post-operative complications. Subgroup analyses revealed that the supplement of n-3 fish oil emulsions was significantly associated with a reduced inflammatory response and risk of post-operative infections. These findings indicate that fat emulsion-based early parenteral nutrition enhances short-term post-operative recovery in patients undergoing hemihepatectomy.

Keywords

HemihepatectomyIntravenous fat emulsionsParenteral nutritionn-3 fatty acidsPerioperative period
Type
Research Article
Information
British Journal of Nutrition , First View , pp. 1 - 10
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of the Nutrition Society

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Footnotes

†

Leyi Liao and Yang Lei contributed equally to this study.

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