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1 results

  • Chapter 2 - Antigens

  • Edited by Anna Porwit, Lunds Universitet, Sweden, Marie Christine Béné, Université de Nantes, France
  • Book:
    Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies
    Published online:
    30 January 2025
    Print publication:
    20 February 2025, pp 15-35

  • Summary

    Flow cytometry relies on the use of fluorochrome-conjugated antibodies, most of them identified and produced after the discovery of the technology allowing to generate large amounts of monoclonal antibodies. Hence, nearly all these reagents are named after the cluster of differentiation (CD) number that was given to newly discovered molecules they recognize, many of them having no other name. Although some CDs have become very popular and well known, others are less familiar. This chapter provides a guide to recover the characteristics of surface or cytoplasmic antigens explored with the CDs most frequently used in the field of haematological malignancies.