Isothiocyanates (ITCs) were evaluated as an alternative to methyl bromide (MeBr) for control of Palmer amaranth, large crabgrass, and yellow nutsedge; reduction of tuber density; and increase in marketable tomato yield in low density polyethylene (LDPE)-mulched tomato production. Allyl ITC was applied at 450, 600, and 750 kg ai ha−1; metham sodium (methyl ITC generator) was applied at 180, 270, and 360 kg ai ha−1; and MeBr plus chloropicrin (mixture of MeBr and chloropicrin at 67 : 33%, respectively) was applied at 390 kg ai ha−1. A nontreated weedy check was included for comparison. There was no injury to tomato plants following allyl ITC, metham sodium, or MeBr application. Allyl ITC at 750 kg ha−1 or metham sodium at 360 kg ha−1 controlled Palmer amaranth ≥ 79%, large crabgrass ≥ 76%, and yellow nutsedge ≥ 80% and was comparable to the weed control with MeBr. Highest rates of allyl ITC and metham sodium reduced yellow nutsedge tuber density (≤ 76 tubers m−2) comparable to the MeBr application. Total marketable tomato yield was ≥ 31.6 t ha−1 in plots treated with allyl ITC at 750 kg ha−1 or metham sodium at 360 kg ha−1. Marketable tomato yield from the highest rate of allyl ITC or metham sodium were similar to the yield (38.2 t ha−1) with MeBr treatment. Therefore, allyl ITC at 750 kg ha−1 and metham sodium at 360 kg ha−1 are effective alternatives to MeBr for Palmer amaranth, large crabgrass, and yellow nutsedge control in LDPE-mulched tomato.