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2 results

  • Diagnostic accuracy of intra-operative assessment of de-epithelisation of the malleus by the surgeon in type 1 tympanoplasty compared to histopathological examination

  • A P Azeez, V Letha
  • Journal:
    The Journal of Laryngology & Otology / Volume 133 / Issue 6 / June 2019
    Published online by Cambridge University Press:
    05 June 2019, pp. 462-465
    Print publication:
    June 2019
  • Objective

    This study was undertaken to determine the accuracy of the surgeon's assessment in detecting epithelial remnants over the malleus after de-epithelisation in tympanoplasty.

    Methods

    Intra-operatively, the umbo was assessed for epithelial remnants with the microscope. The umbo was then resected and sent for histopathological examination to detect epithelial remnants.

    Results

    Out of 42 cases, microscopic examination findings for epithelium were positive in 16 cases and negative in 26 cases. Histopathology findings were positive in 13 cases. The surgeons’ assessment was accurate only in two cases.

    Conclusion

    Residents, with their limited experience, are more likely to leave residual epithelium. When the chance of residual epithelium over the umbo is significant, the surgeon has two choices: to place the graft medial to the umbo or to resect the umbo. It is our opinion that the malleus exteriorisation should be incorporated into tympanoplasty training, with the aim of preventing epithelial entrapment in the middle ear.

  • Failure to demonstrate suppressor T cell activity in the lamina propria of Hymenolepis diminuta-infected rats

  • C. Palmas, D. Wakelin, G. Bortoletti, A. R. Ecca, F. Gabriele
  • Journal:
    Journal of Helminthology / Volume 67 / Issue 1 / March 1993
    Published online by Cambridge University Press:
    05 June 2009, pp. 17-23

  • The aim of this study was to examine whether there was an increase of suppressor T cells, relative to helper T cells, in the intestinal lamina propria of Hymenolepis diminuta-infected rats, a condition which might allow the parasite to survive for the life-span of the host. Lamina propria cells were isolated by enzymatic procedure. All lymphocytes were passed over nylon wool columns in order to remove B cells; then the T cells were purified by a panning technique using monoclonal anti-T cell antibodies. Changes in the mitogen-stimulated synthesis of 1gM, IgG and IgA by normal peripheral blood indicator lymphocytes, as measured by sandwich ELISA, was used as an index of help and/or suppression. No significant suppressor T cell activity was observed in the cultures, either from control or infected intestine.